Excessive heart rate response to orthostatic stress in postural tachycardia syndrome is not caused by anxiety

Shizue Masuki, John H. Eisenach, Christopher P. Johnson, Niki M. Dietz, Lisa M. Benrud-Larson, William G. Schrage, Timothy B Curry, Paola Sandroni, Phillip Anson Low, Michael Joseph Joyner

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Postural tachycardia syndrome (POTS) is characterized by excessive increases in heart rate (HR) without hypotension during orthostasis. The relationship between the tachycardia and anxiety is uncertain. Therefore, we tested whether the HR response to orthostatic stress in POTS is primarily related to psychological factors. POTS patients (n = 14) and healthy controls (n = 10) underwent graded venous pooling with lower body negative pressure (LBNP) to -40 mmHg while wearing deflated antishock trousers. "Sham" venous pooling was performed by 1) trouser inflation to 5 mmHg during LBNP and 2) vacuum pump activation without LBNP. HR responses to mental stress were also measured in both groups, and a questionnaire was used to measure psychological parameters. During LBNP, HR in POTS patients increased 39 ± 5 beats/min vs. 19 ± 3 beats/min in control subjects at -40 mmHg (P < 0.01). LBNP with trouser inflation markedly blunted the HR responses in the patients (9 ± 2 beats/min) and controls (2 ± 1 beats/min), and there was no HR increase during vacuum application without LBNP in either group. HR responses during mental stress were not different in the patients and controls (18 ± 2 vs. 19 ± 1 beats/min; P > 0.6). Anxiety, somatic vigilance, and catastrophic cognitions were significantly higher in the patients (P < 0.05), but they were not related to the HR responses during LBNP or mental stress (P > 0.1). These results suggest that the HR response to orthostatic stress in POTS patients is not caused by anxiety but that it is a physiological response that maintains arterial pressure during venous pooling.

Original languageEnglish (US)
Pages (from-to)896-903
Number of pages8
JournalJournal of Applied Physiology
Volume102
Issue number3
DOIs
StatePublished - Mar 2007

Fingerprint

Postural Orthostatic Tachycardia Syndrome
Lower Body Negative Pressure
Anxiety
Heart Rate
Gravity Suits
Psychology
Economic Inflation
Dizziness
Vacuum
Tachycardia
Hypotension
Cognition
Arterial Pressure

Keywords

  • Blood pressure
  • Mental stress
  • Orthostatic intolerance
  • Sympathetic nervous system
  • Venous pooling

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Excessive heart rate response to orthostatic stress in postural tachycardia syndrome is not caused by anxiety. / Masuki, Shizue; Eisenach, John H.; Johnson, Christopher P.; Dietz, Niki M.; Benrud-Larson, Lisa M.; Schrage, William G.; Curry, Timothy B; Sandroni, Paola; Low, Phillip Anson; Joyner, Michael Joseph.

In: Journal of Applied Physiology, Vol. 102, No. 3, 03.2007, p. 896-903.

Research output: Contribution to journalArticle

Masuki, Shizue ; Eisenach, John H. ; Johnson, Christopher P. ; Dietz, Niki M. ; Benrud-Larson, Lisa M. ; Schrage, William G. ; Curry, Timothy B ; Sandroni, Paola ; Low, Phillip Anson ; Joyner, Michael Joseph. / Excessive heart rate response to orthostatic stress in postural tachycardia syndrome is not caused by anxiety. In: Journal of Applied Physiology. 2007 ; Vol. 102, No. 3. pp. 896-903.
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