Abstract

There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer’s disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P <.05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P <.01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.

Original languageEnglish (US)
JournalAmerican Journal of Alzheimer's Disease and Other Dementias
DOIs
StatePublished - Jan 1 2019

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Dementia
Lewy Body Disease
Alzheimer Disease
Frontotemporal Dementia

Keywords

  • Alzheimer’s disease
  • dementia with Lewy bodies
  • excessive daytime sleepiness
  • frontotemporal dementia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

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title = "Excessive Daytime Sleepiness in Major Dementia Syndromes",
abstract = "There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer’s disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P <.05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81{\%} vs bvFTD 47{\%} vs AD 45{\%}, P <.01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.",
keywords = "Alzheimer’s disease, dementia with Lewy bodies, excessive daytime sleepiness, frontotemporal dementia",
author = "Angelica Boeve and Ferman, {Tanis Jill} and Jeremiah Aakre and {St Louis}, {Erik K} and Michael Silber and Machulda, {Mary Margaret} and Fields, {Julie A} and {Graff Radford}, {Neill R} and Mielke, {Michelle M} and Geda, {Yonas Endale} and Jones, {David T} and Jonathan Graff-Radford and Knopman, {David S} and Petersen, {Ronald Carl} and Boeve, {Bradley F}",
year = "2019",
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doi = "10.1177/1533317519828046",
language = "English (US)",
journal = "American Journal of Alzheimer's Disease and other Dementias",
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AU - Ferman, Tanis Jill

AU - Aakre, Jeremiah

AU - St Louis, Erik K

AU - Silber, Michael

AU - Machulda, Mary Margaret

AU - Fields, Julie A

AU - Graff Radford, Neill R

AU - Mielke, Michelle M

AU - Geda, Yonas Endale

AU - Jones, David T

AU - Graff-Radford, Jonathan

AU - Knopman, David S

AU - Petersen, Ronald Carl

AU - Boeve, Bradley F

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