Excessive Daytime Sleepiness in Major Dementia Syndromes

Angelica Boeve; Tanis J. Ferman; Jeremiah Aakre; Erik St. Louis; Michael Silber; Mary Machulda; Julie Fields; Neill Graff-Radford; Michelle Mielke; Yonas Geda; David Jones; Jonathon Graff-Radford; David Knopman; Ronald Petersen; Brad Boeve

doi:10.1177/1533317519828046

Excessive Daytime Sleepiness in Major Dementia Syndromes

Angelica Boeve, Tanis J. Ferman, Jeremiah Aakre, Erik St. Louis, Michael Silber, Mary Machulda, Julie Fields, Neill Graff-Radford, Michelle Mielke, Yonas Geda, David Jones, Jonathon Graff-Radford, David Knopman, Ronald Petersen, Brad Boeve

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer’s disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P <.05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P <.01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.

Original language	English (US)
Pages (from-to)	261-264
Number of pages	4
Journal	American Journal of Alzheimer's Disease and Other Dementias
Volume	34
Issue number	4
DOIs	https://doi.org/10.1177/1533317519828046
State	Published - Jun 1 2019

Keywords

Alzheimer’s disease
dementia with Lewy bodies
excessive daytime sleepiness
frontotemporal dementia

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.1177/1533317519828046

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Boeve, A., Ferman, T. J., Aakre, J., St. Louis, E., Silber, M., Machulda, M., Fields, J., Graff-Radford, N., Mielke, M., Geda, Y., Jones, D., Graff-Radford, J., Knopman, D., Petersen, R., & Boeve, B. (2019). Excessive Daytime Sleepiness in Major Dementia Syndromes. American Journal of Alzheimer's Disease and Other Dementias, 34(4), 261-264. https://doi.org/10.1177/1533317519828046

Boeve, A, Ferman, TJ, Aakre, J, St. Louis, E, Silber, M, Machulda, M , Fields, J , Graff-Radford, N, Mielke, M, Geda, Y, Jones, D , Graff-Radford, J , Knopman, D , Petersen, R & Boeve, B 2019, 'Excessive Daytime Sleepiness in Major Dementia Syndromes', American Journal of Alzheimer's Disease and Other Dementias, vol. 34, no. 4, pp. 261-264. https://doi.org/10.1177/1533317519828046

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abstract = "There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer{\textquoteright}s disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P <.05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P <.01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.",

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AU - Petersen, Ronald

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Excessive Daytime Sleepiness in Major Dementia Syndromes

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