Examining racial differences in diffuse large B-cell lymphoma presentation and survival

Christopher R. Flowers, Pareen J. Shenoy, Uma Borate, Kevin Bumpers, Tanyanika Douglas-Holland, Nassoma King, Otis W. Brawley, Joseph Lipscomb, Mary Jo Lechowicz, Rajni Sinha, Rajinder S. Grover, Leon Bernal-Mizrachi, Jeanne Kowalski, Will Donnellan, Angelina The, Vishnu Reddy, David L. Jaye, James M Foran

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We performed a retrospective cohort analysis of 701 (533 white and 144 black) patients with diffuse large B-cell lymphoma (DLBCL) treated at two referral centers in southern United States between 1981 and 2010. Median age of diagnosis for blacks was 50 years vs. 57 years for whites (p < 0.001). A greater percentage of blacks presented with elevated lactate dehydrogenase levels, B-symptoms and performance status ≥ 2. More whites (8%) than blacks (3%) had a positive family history of lymphoma (p = 0.048). There were no racial differences in the use of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone; 52% black vs. 47% white, p = 0.73). While black race predicted worse survival among patients treated with CHOP (hazard ratio [HR] 1.8, p < 0.001), treatment with R-CHOP was associated with improved survival irrespective of race (HR 0.61, p = 0.01). Future studies should examine biological differences that may underlie the observed racial differences in presentation and outcome.

Original languageEnglish (US)
Pages (from-to)268-276
Number of pages9
JournalLeukemia and Lymphoma
Volume54
Issue number2
DOIs
StatePublished - Feb 2013

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Lymphoma, Large B-Cell, Diffuse
Survival
Vincristine
Prednisone
Doxorubicin
Cyclophosphamide
Lymphoma
Cohort Studies
Referral and Consultation
hydroquinone
Therapeutics
lactate dehydrogenase 1
Rituximab

Keywords

  • CHOP regimen
  • Diffuse large B-cell lymphoma
  • Disparities
  • Outcomes
  • R-CHOP regimen
  • Race

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Flowers, C. R., Shenoy, P. J., Borate, U., Bumpers, K., Douglas-Holland, T., King, N., ... Foran, J. M. (2013). Examining racial differences in diffuse large B-cell lymphoma presentation and survival. Leukemia and Lymphoma, 54(2), 268-276. https://doi.org/10.3109/10428194.2012.708751

Examining racial differences in diffuse large B-cell lymphoma presentation and survival. / Flowers, Christopher R.; Shenoy, Pareen J.; Borate, Uma; Bumpers, Kevin; Douglas-Holland, Tanyanika; King, Nassoma; Brawley, Otis W.; Lipscomb, Joseph; Lechowicz, Mary Jo; Sinha, Rajni; Grover, Rajinder S.; Bernal-Mizrachi, Leon; Kowalski, Jeanne; Donnellan, Will; The, Angelina; Reddy, Vishnu; Jaye, David L.; Foran, James M.

In: Leukemia and Lymphoma, Vol. 54, No. 2, 02.2013, p. 268-276.

Research output: Contribution to journalArticle

Flowers, CR, Shenoy, PJ, Borate, U, Bumpers, K, Douglas-Holland, T, King, N, Brawley, OW, Lipscomb, J, Lechowicz, MJ, Sinha, R, Grover, RS, Bernal-Mizrachi, L, Kowalski, J, Donnellan, W, The, A, Reddy, V, Jaye, DL & Foran, JM 2013, 'Examining racial differences in diffuse large B-cell lymphoma presentation and survival', Leukemia and Lymphoma, vol. 54, no. 2, pp. 268-276. https://doi.org/10.3109/10428194.2012.708751
Flowers CR, Shenoy PJ, Borate U, Bumpers K, Douglas-Holland T, King N et al. Examining racial differences in diffuse large B-cell lymphoma presentation and survival. Leukemia and Lymphoma. 2013 Feb;54(2):268-276. https://doi.org/10.3109/10428194.2012.708751
Flowers, Christopher R. ; Shenoy, Pareen J. ; Borate, Uma ; Bumpers, Kevin ; Douglas-Holland, Tanyanika ; King, Nassoma ; Brawley, Otis W. ; Lipscomb, Joseph ; Lechowicz, Mary Jo ; Sinha, Rajni ; Grover, Rajinder S. ; Bernal-Mizrachi, Leon ; Kowalski, Jeanne ; Donnellan, Will ; The, Angelina ; Reddy, Vishnu ; Jaye, David L. ; Foran, James M. / Examining racial differences in diffuse large B-cell lymphoma presentation and survival. In: Leukemia and Lymphoma. 2013 ; Vol. 54, No. 2. pp. 268-276.
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