TY - JOUR
T1 - Examination of prevalence rates of possible risk factors in a population with a fracture of the proximal femur
AU - Gallagher, J. C.
AU - Melton, L. J.
AU - Riggs, B. L.
PY - 1980
Y1 - 1980
N2 - No statistical increase in the prevalence of either diabetes, rheumatoid arthritis or primary hyperparathyroidism was found among the hip fracture patient population. Since the relative risks for these diseases is small, the statistics suggest that these conditions are either noncontributory or represent only a minor risk factor in the overall pathogenesis of hip fractures. About 20% of the hip fracture patients had a history of other identifiable risk factors such as thyrotoxicosis, hemiplegia, malabsorption syndromes and corticosteroid therapy. Of these conditions only thyrotoxicosis could be evaluated by comparison of prevalence rates, and a significant increase was found among the fracture patients. A highly significant correlation was found between the side of a previous hemiplegia and side of the subsequent hip fracture; this may be due to the development of disuse osteoporosis in the hemiplegic limb. Recent reports have shown that a reduction in the number of hip fractures is associated with a high calcium intake or prophylactic estrogen therapy. Preventive therapy in patients with hemiplegia, thyrotoxicosis, or other predisposing conditions leading to osteopenia might result in a further reduction of the hip fracture rate.
AB - No statistical increase in the prevalence of either diabetes, rheumatoid arthritis or primary hyperparathyroidism was found among the hip fracture patient population. Since the relative risks for these diseases is small, the statistics suggest that these conditions are either noncontributory or represent only a minor risk factor in the overall pathogenesis of hip fractures. About 20% of the hip fracture patients had a history of other identifiable risk factors such as thyrotoxicosis, hemiplegia, malabsorption syndromes and corticosteroid therapy. Of these conditions only thyrotoxicosis could be evaluated by comparison of prevalence rates, and a significant increase was found among the fracture patients. A highly significant correlation was found between the side of a previous hemiplegia and side of the subsequent hip fracture; this may be due to the development of disuse osteoporosis in the hemiplegic limb. Recent reports have shown that a reduction in the number of hip fractures is associated with a high calcium intake or prophylactic estrogen therapy. Preventive therapy in patients with hemiplegia, thyrotoxicosis, or other predisposing conditions leading to osteopenia might result in a further reduction of the hip fracture rate.
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U2 - 10.1097/00003086-198011000-00021
DO - 10.1097/00003086-198011000-00021
M3 - Article
C2 - 6893815
AN - SCOPUS:0019125017
SN - 0009-921X
VL - 153
SP - 158
EP - 165
JO - Clinical orthopaedics and related research
JF - Clinical orthopaedics and related research
ER -