Abstract
Stiffening of the left ventricle can compromise the ability of the heart to pump sufficient amounts of blood into the systemic circulation and could lead to heart failure. Quantifying mechanical properties of the left ventricular (LV) myocardium using a noninvasive technique would be of great benefit in clinical settings. We investigated the feasibility of using Shearwave Dispersion Ultrasound Vibrometry (SDUV) to measure viscoelasticity of the myocardium. A mechanical actuator was used to induce shear waves at multiple frequencies (40-500 Hz) in excised LV myocardium and urethane rubber samples, and a pulse echo ultrasound transducer was used to detect the motion at each frequency. An anti-symmetric Lamb wave model was fit to the shear wave dispersion curves in four orthogonal directions to obtain elastic and viscous moduli.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 |
| Pages | 2895-2898 |
| Number of pages | 4 |
| DOIs | |
| State | Published - 2009 |
| Event | 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States Duration: Sep 2 2009 → Sep 6 2009 |
Other
| Other | 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 |
|---|---|
| Country | United States |
| City | Minneapolis, MN |
| Period | 9/2/09 → 9/6/09 |
Fingerprint
ASJC Scopus subject areas
- Cell Biology
- Developmental Biology
- Biomedical Engineering
- Medicine(all)
Cite this
Ex vivo measurements of myocardial viscoelasticity using Shearwave Dispersion Ultrasound Vibrometry (SDUV). / Nenadic, Ivan; Urban, Matthew W; Greenleaf, James F.
Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 2895-2898 5334448.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Ex vivo measurements of myocardial viscoelasticity using Shearwave Dispersion Ultrasound Vibrometry (SDUV)
AU - Nenadic, Ivan
AU - Urban, Matthew W
AU - Greenleaf, James F
PY - 2009
Y1 - 2009
N2 - Stiffening of the left ventricle can compromise the ability of the heart to pump sufficient amounts of blood into the systemic circulation and could lead to heart failure. Quantifying mechanical properties of the left ventricular (LV) myocardium using a noninvasive technique would be of great benefit in clinical settings. We investigated the feasibility of using Shearwave Dispersion Ultrasound Vibrometry (SDUV) to measure viscoelasticity of the myocardium. A mechanical actuator was used to induce shear waves at multiple frequencies (40-500 Hz) in excised LV myocardium and urethane rubber samples, and a pulse echo ultrasound transducer was used to detect the motion at each frequency. An anti-symmetric Lamb wave model was fit to the shear wave dispersion curves in four orthogonal directions to obtain elastic and viscous moduli.
AB - Stiffening of the left ventricle can compromise the ability of the heart to pump sufficient amounts of blood into the systemic circulation and could lead to heart failure. Quantifying mechanical properties of the left ventricular (LV) myocardium using a noninvasive technique would be of great benefit in clinical settings. We investigated the feasibility of using Shearwave Dispersion Ultrasound Vibrometry (SDUV) to measure viscoelasticity of the myocardium. A mechanical actuator was used to induce shear waves at multiple frequencies (40-500 Hz) in excised LV myocardium and urethane rubber samples, and a pulse echo ultrasound transducer was used to detect the motion at each frequency. An anti-symmetric Lamb wave model was fit to the shear wave dispersion curves in four orthogonal directions to obtain elastic and viscous moduli.
UR - http://www.scopus.com/inward/record.url?scp=77950966766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950966766&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2009.5334448
DO - 10.1109/IEMBS.2009.5334448
M3 - Conference contribution
SN - 9781424432967
SP - 2895
EP - 2898
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
ER -