| Original language | English (US) |
|---|---|
| Pages (from-to) | 139-143 |
| Number of pages | 5 |
| Journal | Osteoarthritis and Cartilage |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1997 |
Keywords
- cartilage injury
- chondrocytes
- gene therapy
- transplantation
ASJC Scopus subject areas
- Rheumatology
- Biomedical Engineering
- Orthopedics and Sports Medicine
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In: Osteoarthritis and Cartilage, Vol. 5, No. 2, 1997, p. 139-143.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects
T2 - A feasibility study
AU - Kang, R.
AU - Marui, T.
AU - Ghivizzani, S. C.
AU - Nita, I. M.
AU - Georgescu, H. I.
AU - Suh, J. K.
AU - Robbins, P. D.
AU - Evans, C. H.
N1 - Funding Information: IT IS well-established that damaged articular cartilage has only a limited ability to repair itself \[1\]. Recently, Brittburg et al. reported the treatment of full-thickness articular defects in the human knee by transplantation of cultured autologous chondrocytes \[2\].T his work was an extension of animal studies involving the transplantation of chondrocytes or their progenitors into similar defects \[3-11\]. However, the success of all of these techniques has been variable, and limited in that none were able to demonstrate long-term repair of the damaged cartilage with tissue that was histologically, biochemically, and biomechanically identical to normal cartilage. Several cytokines, including transforming growth factor ~-1 (TGF-~I) and insulin-like growth factor-1 (IGF-1), have been found to play significant roles in promoting chondrocyte anabolism and inhibiting chondrocyte catabolism (reviewed in \[12\]).T hus, the presence of one or more of these cytokines during repair may be the key to regenerating normal cartilage \[3\]H. owever, sustained delivery of sufficient quantities of a cytokine(s) to transplanted cells bound within a three-dimensional matrix would be difficult and impractical using conventional methods. Gene therapy offers an elegant solution to this delivery problem \[13\]B. y introducing an exogenous gene(s) into cells prior to transplantation, a therapeutic cytokine(s) may be expressed in vivo at Received 25 June 1996; accepted 3 October 1996. Supported, in part, by the Ferguson Foundation and NIH Grant PO1 DK44935 Address correspondence to: C. H. Evans, Ph.D, 986 Scaife Hall, Ferguson laboratory, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, U.S.A.
PY - 1997
Y1 - 1997
KW - cartilage injury
KW - chondrocytes
KW - gene therapy
KW - transplantation
UR - http://www.scopus.com/inward/record.url?scp=0030893301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030893301&partnerID=8YFLogxK
U2 - 10.1016/S1063-4584(97)80007-6
DO - 10.1016/S1063-4584(97)80007-6
M3 - Article
C2 - 9135825
AN - SCOPUS:0030893301
SN - 1063-4584
VL - 5
SP - 139
EP - 143
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 2
ER -