Ewing's sarcoma of the proximal femur

Timothy A. Damron, Franklin H. Sim, Mary I. O'Connor, Douglas J. Pritchard, William A. Smithson

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The cases of 16 patients with Ewing's sarcoma of the proximal femur treated in the era of multiagent chemotherapy were reviewed, with emphasis on the mechanical problem of tumor involvement in this structurally demanding site. Fourteen patients received chemotherapy and local radiotherapy as the initial primary treatment. One patient had chemotherapy and radiotherapy, followed by wide local resection. One patient had amputation, followed by chemotherapy, for pathologic fracture and extensive soft tissue involvement at presentation. Two local reccurrences occurred. Excluding the 2 patients whose femurs were fixed prophylactically, the pathologic fracture rate was 79%. In addition, by excluding the 2 patients who died before fracture, the pathologic fracture rate was 92%. Nonunion occurred in 5 (71%) of the 7 pathologic fractures not treated by resection and required as many as 5 additional surgical procedures to obtain union. At latest followup evaluation (average, 6.3 years), 10 patients had no evidence of disease, 1 was alive with disease, and 5 had died of their disease. Options for management should include primary resection and reconstruction or prophylactic internal fixation after completion of chemotherapy plus or minus radiotherapy.

Original languageEnglish (US)
Pages (from-to)232-244
Number of pages13
JournalClinical orthopaedics and related research
Issue number322
DOIs
StatePublished - Jan 1996

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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    Damron, T. A., Sim, F. H., O'Connor, M. I., Pritchard, D. J., & Smithson, W. A. (1996). Ewing's sarcoma of the proximal femur. Clinical orthopaedics and related research, (322), 232-244. https://doi.org/10.1097/00003086-199601000-00028