TY - JOUR
T1 - Evolving molecular targets in the treatment of nonmalignant gastrointestinal diseases
AU - Katzka, D. A.
AU - Loftus, E. V.
AU - Camilleri, M.
PY - 2012/9
Y1 - 2012/9
N2 - Novel treatments for gastrointestinal (GI) diseases are based on molecular targets. Novel pharmacologic and biological agents with greater selectivity and specificity are being developed for a variety of epithelial diseases, including eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), celiac disease, short bowel syndrome (SBS), and inflammatory bowel diseases (IBDs; Crohn's disease and ulcerative colitis). Motility and secretory agents are being developed for gastroparesis, irritable bowel syndrome (IBS), functional constipation, and diarrhea. Here we focus on data from clinical trials involving validated pharmacodynamic or patient response outcomes.
AB - Novel treatments for gastrointestinal (GI) diseases are based on molecular targets. Novel pharmacologic and biological agents with greater selectivity and specificity are being developed for a variety of epithelial diseases, including eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), celiac disease, short bowel syndrome (SBS), and inflammatory bowel diseases (IBDs; Crohn's disease and ulcerative colitis). Motility and secretory agents are being developed for gastroparesis, irritable bowel syndrome (IBS), functional constipation, and diarrhea. Here we focus on data from clinical trials involving validated pharmacodynamic or patient response outcomes.
UR - http://www.scopus.com/inward/record.url?scp=84865424516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865424516&partnerID=8YFLogxK
U2 - 10.1038/clpt.2012.77
DO - 10.1038/clpt.2012.77
M3 - Article
C2 - 22828717
AN - SCOPUS:84865424516
SN - 0009-9236
VL - 92
SP - 306
EP - 320
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 3
ER -