Evolutionary clues to the functions of the Toll-like family as surveillance receptors

Geoffrey B. Johnson, Gregory J. Brunn, Amy H. Tang, Jeffrey L. Platt

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in evolution, is a topic of extensive debate. We postulate a surveillance model: these receptors 'keep watch' for both endogenous and exogenous molecules that indicate tissue injury, infection and remodeling. Furthermore, we suggest that the first Toll-like family receptors that arose in evolution might have acted in both development and immunity by recognizing the degradation of endogenous macromolecules.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalTrends in Immunology
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2003

Fingerprint

Toll-Like Receptors
Immunity
Wounds and Injuries
Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Evolutionary clues to the functions of the Toll-like family as surveillance receptors. / Johnson, Geoffrey B.; Brunn, Gregory J.; Tang, Amy H.; Platt, Jeffrey L.

In: Trends in Immunology, Vol. 24, No. 1, 01.01.2003, p. 19-24.

Research output: Contribution to journalArticle

Johnson, Geoffrey B. ; Brunn, Gregory J. ; Tang, Amy H. ; Platt, Jeffrey L. / Evolutionary clues to the functions of the Toll-like family as surveillance receptors. In: Trends in Immunology. 2003 ; Vol. 24, No. 1. pp. 19-24.
@article{b50a8480af2a47f3ac241e177bb8a0d4,
title = "Evolutionary clues to the functions of the Toll-like family as surveillance receptors",
abstract = "The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in evolution, is a topic of extensive debate. We postulate a surveillance model: these receptors 'keep watch' for both endogenous and exogenous molecules that indicate tissue injury, infection and remodeling. Furthermore, we suggest that the first Toll-like family receptors that arose in evolution might have acted in both development and immunity by recognizing the degradation of endogenous macromolecules.",
author = "Johnson, {Geoffrey B.} and Brunn, {Gregory J.} and Tang, {Amy H.} and Platt, {Jeffrey L.}",
year = "2003",
month = "1",
day = "1",
doi = "10.1016/S1471-4906(02)00014-5",
language = "English (US)",
volume = "24",
pages = "19--24",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Evolutionary clues to the functions of the Toll-like family as surveillance receptors

AU - Johnson, Geoffrey B.

AU - Brunn, Gregory J.

AU - Tang, Amy H.

AU - Platt, Jeffrey L.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in evolution, is a topic of extensive debate. We postulate a surveillance model: these receptors 'keep watch' for both endogenous and exogenous molecules that indicate tissue injury, infection and remodeling. Furthermore, we suggest that the first Toll-like family receptors that arose in evolution might have acted in both development and immunity by recognizing the degradation of endogenous macromolecules.

AB - The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in evolution, is a topic of extensive debate. We postulate a surveillance model: these receptors 'keep watch' for both endogenous and exogenous molecules that indicate tissue injury, infection and remodeling. Furthermore, we suggest that the first Toll-like family receptors that arose in evolution might have acted in both development and immunity by recognizing the degradation of endogenous macromolecules.

UR - http://www.scopus.com/inward/record.url?scp=0037213692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037213692&partnerID=8YFLogxK

U2 - 10.1016/S1471-4906(02)00014-5

DO - 10.1016/S1471-4906(02)00014-5

M3 - Article

C2 - 12495720

AN - SCOPUS:0037213692

VL - 24

SP - 19

EP - 24

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 1

ER -