Evolution of Hematopoietic Cell Transplantation for Immunoglobulin Light Chain Amyloidosis

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6 Citations (Scopus)

Abstract

Immunoglobulin light chain amyloidosis is the most common type of systemic amyloidosis. Hematopoietic stem cell transplantation (HCT) is an effective treatment option for AL however due to multi-organ involvement in this disease HCT is feasible in a minority of patients. To maximize the benefit and minimize toxicity it is of paramount importance to optimize the selection of patients for HCT. In this review we discuss evolution of HCT and its typical application to a case of AL amyloidosis.

Original languageEnglish (US)
JournalBiology of Blood and Marrow Transplantation
DOIs
StateAccepted/In press - Jun 29 2015

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Immunoglobulin Light Chains
Hematopoietic Stem Cell Transplantation
Cell Transplantation
Amyloidosis
Patient Selection

Keywords

  • AL amyloidosis
  • Hematopoeitic stem cell transplantation
  • Immunoglobulin light chain amyloidosis
  • Stem cell transplantation

ASJC Scopus subject areas

  • Transplantation
  • Hematology

Cite this

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title = "Evolution of Hematopoietic Cell Transplantation for Immunoglobulin Light Chain Amyloidosis",
abstract = "Immunoglobulin light chain amyloidosis is the most common type of systemic amyloidosis. Hematopoietic stem cell transplantation (HCT) is an effective treatment option for AL however due to multi-organ involvement in this disease HCT is feasible in a minority of patients. To maximize the benefit and minimize toxicity it is of paramount importance to optimize the selection of patients for HCT. In this review we discuss evolution of HCT and its typical application to a case of AL amyloidosis.",
keywords = "AL amyloidosis, Hematopoeitic stem cell transplantation, Immunoglobulin light chain amyloidosis, Stem cell transplantation",
author = "Taimur Sher and Angela Dispenzieri and Morie Gertz",
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language = "English (US)",
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AU - Sher, Taimur

AU - Dispenzieri, Angela

AU - Gertz, Morie

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Y1 - 2015/6/29

N2 - Immunoglobulin light chain amyloidosis is the most common type of systemic amyloidosis. Hematopoietic stem cell transplantation (HCT) is an effective treatment option for AL however due to multi-organ involvement in this disease HCT is feasible in a minority of patients. To maximize the benefit and minimize toxicity it is of paramount importance to optimize the selection of patients for HCT. In this review we discuss evolution of HCT and its typical application to a case of AL amyloidosis.

AB - Immunoglobulin light chain amyloidosis is the most common type of systemic amyloidosis. Hematopoietic stem cell transplantation (HCT) is an effective treatment option for AL however due to multi-organ involvement in this disease HCT is feasible in a minority of patients. To maximize the benefit and minimize toxicity it is of paramount importance to optimize the selection of patients for HCT. In this review we discuss evolution of HCT and its typical application to a case of AL amyloidosis.

KW - AL amyloidosis

KW - Hematopoeitic stem cell transplantation

KW - Immunoglobulin light chain amyloidosis

KW - Stem cell transplantation

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