Evidence that the lung adenocarcinoma EML4-ALK fusion gene is not caused by exposure to secondhand tobacco smoke during childhood

Bríd M. Ryan, Yi Wang, Jin Jen, Eunhee S. Yi, Susan Olivo-Marston, Ping Yang, Curtis C. Harris

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The EML4-ALK fusion gene is more frequently found in younger, never smoking patients with lung cancer. Meanwhile, never smokers exposed to secondhand tobacco smoke (SHS) during childhood are diagnosed at a younger age compared with never smoking patients with lung cancer who are not exposed. We, therefore, hypothesized that SHS, which can induce DNA damage, is associated with the EML4-ALK fusion gene. Methods: We compared the frequency of the EML4-ALK fusion gene among 197 never smoker patients with lung cancer with and without a history of exposure to SHS during childhood at Mayo Clinic. Results: The EML4-ALK fusion gene was detected in 33% of cases from never smokers with a history of SHS exposure during childhood, whereas 47% of never smoking lung cancer cases without a history of childhood SHS exposure tested positive for the fusion gene. Conclusions: The EML4-ALK fusion gene is not enriched in tumors from individuals exposed to SHS during childhood. Impact: These data suggest that childhood exposure to SHS is not a significant etiologic cause of the EML4- ALK fusion gene in lung cancer.

Original languageEnglish (US)
Pages (from-to)1432-1434
Number of pages3
JournalCancer Epidemiology Biomarkers and Prevention
Volume23
Issue number7
DOIs
StatePublished - 2014

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Tobacco Smoke Pollution
Gene Fusion
Tobacco
Lung Neoplasms
Smoking
Adenocarcinoma of lung
DNA Damage

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Evidence that the lung adenocarcinoma EML4-ALK fusion gene is not caused by exposure to secondhand tobacco smoke during childhood. / Ryan, Bríd M.; Wang, Yi; Jen, Jin; Yi, Eunhee S.; Olivo-Marston, Susan; Yang, Ping; Harris, Curtis C.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 23, No. 7, 2014, p. 1432-1434.

Research output: Contribution to journalArticle

Ryan, Bríd M. ; Wang, Yi ; Jen, Jin ; Yi, Eunhee S. ; Olivo-Marston, Susan ; Yang, Ping ; Harris, Curtis C. / Evidence that the lung adenocarcinoma EML4-ALK fusion gene is not caused by exposure to secondhand tobacco smoke during childhood. In: Cancer Epidemiology Biomarkers and Prevention. 2014 ; Vol. 23, No. 7. pp. 1432-1434.
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AU - Jen, Jin

AU - Yi, Eunhee S.

AU - Olivo-Marston, Susan

AU - Yang, Ping

AU - Harris, Curtis C.

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