Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice

W. C. Benzing, J. R. Wujek, E. K. Ward, D. Shaffer, K. H. Ashe, S. G. Younkin, K. R. Brunden

Research output: Contribution to journalArticlepeer-review

236 Scopus citations

Abstract

Chronic expression of inflammatory cytokines, including interleukin-1β, tumor necrosis factor α, and interleukin-6, by glia may underlie the neurodegenerative events that occur within the brains of patients with Alzheimer's disease (AD). The present study determined whether these markers of inflammation could be observed within the brains of Tg(HuAPP695.K670N/M671L)2576 transgenic mice (Tg2576) that have recently been shown to mimic many features of AD. Interleukin-1β- and tumor necrosis factor α-immunopositive microglia were localized with thioflavine-positive (fibrillar) Aβ deposits. Moreover, interleukin-6 immunoreactive astrocytes surrounded fibrillar Aβ deposits. These findings provide evidence that Tg2576 mice exhibit features of the inflammatory pathology seen in AD and suggest that these mice are a useful animal model for studying the role inflammation may play in this disease. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)581-589
Number of pages9
JournalNeurobiology of aging
Volume20
Issue number6
DOIs
StatePublished - Nov 1 1999

Keywords

  • Alzheimer's disease
  • Animal model
  • Cytokine
  • Glia
  • IL-1β
  • IL-6
  • Immunocytochemistry
  • Inflammation
  • Mouse
  • TNF
  • Transgenic

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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