Evidence for GABAergic inhibitory deficits in major depressive disorder

Paul E Croarkin, Andrea J. Levinson, Zafiris J. Daskalakis

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

Converging evidence suggests that deficits in gamma-aminobutyric acid (GABA) functioning are implicated in the pathophysiology of major depressive disorder (MDD). This is highlighted by research investigating cortical inhibition (CI), a process whereby GABAergic interneurons selectively attenuate pyramidal neurons. Transcranial magnetic stimulation (TMS) paradigms evaluate this marker of neuronal inhibitory activity in the cortex. This review will examine the neuroanatomic and neurophysiological evidence from neuroimaging, molecular, treatment, and TMS studies linking dysfunctional GABAergic neurotransmission to MDD.

Original languageEnglish (US)
Pages (from-to)818-825
Number of pages8
JournalNeuroscience and Biobehavioral Reviews
Volume35
Issue number3
DOIs
StatePublished - Jan 2011
Externally publishedYes

Fingerprint

Transcranial Magnetic Stimulation
Major Depressive Disorder
Pyramidal Cells
Interneurons
Neuroimaging
Synaptic Transmission
gamma-Aminobutyric Acid
Research
Therapeutics
Inhibition (Psychology)

Keywords

  • Cortical inhibition
  • GABA
  • Interneuron
  • Major depressive disorder
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Evidence for GABAergic inhibitory deficits in major depressive disorder. / Croarkin, Paul E; Levinson, Andrea J.; Daskalakis, Zafiris J.

In: Neuroscience and Biobehavioral Reviews, Vol. 35, No. 3, 01.2011, p. 818-825.

Research output: Contribution to journalReview article

Croarkin, Paul E ; Levinson, Andrea J. ; Daskalakis, Zafiris J. / Evidence for GABAergic inhibitory deficits in major depressive disorder. In: Neuroscience and Biobehavioral Reviews. 2011 ; Vol. 35, No. 3. pp. 818-825.
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