Evidence-based review of genomic aberrations in B-lymphoblastic leukemia/lymphoma: Report from the cancer genomics consortium working group for lymphoblastic leukemia

Yassmine M.N. Akkari, Helene Bruyere, R. Tanner Hagelstrom, Rashmi Kanagal-Shamanna, Jie Liu, Minjie Luo, Fady M. Mikhail, Beth A. Pitel, Gordana Raca, Mary Shago, Lina Shao, Lisa R. Smith, Teresa A. Smolarek, Ashwini Yenamandra, Linda B. Baughn

Research output: Contribution to journalReview article

Abstract

Clinical management and risk stratification of B-lymphoblastic leukemia/ lymphoma (B-ALL/LBL) depend largely on identification of chromosomal abnormalities obtained using conventional cytogenetics and Fluorescence In Situ Hybridization (FISH) testing. In the last few decades, testing algorithms have been implemented to support an optimal risk-oriented therapy, leading to a large improvement in overall survival. In addition, large scale genomic studies have identified multiple aberrations of prognostic significance that are not routinely tested by existing modalities. However, as chromosomal microarray analysis (CMA) and next-generation sequencing (NGS) technologies are increasingly used in clinical management of hematologic malignancies, these abnormalities may be more readily detected. In this article, we have compiled a comprehensive, evidence-based review of the current B-ALL literature, focusing on known and published subtypes described to date. More specifically, we describe the role of various testing modalities in the diagnosis, prognosis, and therapeutic relevance. In addition, we propose a testing algorithm aimed at assisting laboratories in the most effective detection of the underlying genomic abnormalities.

Original languageEnglish (US)
Pages (from-to)52-72
Number of pages21
JournalCancer Genetics
Volume243
DOIs
StatePublished - May 2020

Keywords

  • B-ALL
  • Chromosomal microarray Analysis
  • Diagnosis
  • FISH
  • NGS
  • Prognosis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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  • Cite this

    Akkari, Y. M. N., Bruyere, H., Hagelstrom, R. T., Kanagal-Shamanna, R., Liu, J., Luo, M., Mikhail, F. M., Pitel, B. A., Raca, G., Shago, M., Shao, L., Smith, L. R., Smolarek, T. A., Yenamandra, A., & Baughn, L. B. (2020). Evidence-based review of genomic aberrations in B-lymphoblastic leukemia/lymphoma: Report from the cancer genomics consortium working group for lymphoblastic leukemia. Cancer Genetics, 243, 52-72. https://doi.org/10.1016/j.cancergen.2020.03.001