Evidence-based mini-review: the role of alkylating agents in the initial treatment of chronic lymphocytic leukemia patients with the 11q deletion.

Wei D Ding, Alessandra Ferrajoli

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A 55-year-old man presented with fever, night sweats, and weight loss of about 20 lbs. in the prior 6 months. Physical examination revealed multiple cervical, axillary, and inguinal lymphadenopathy. The spleen was enlarged. A complete blood count revealed leukocytosis with absolute lymphocytosis: 30,000/μL. Peripheral blood-flow cytometric analysis showed a clonal lymphocyte population with immunophenotypes positive for CD5, CD20(dim), and monotypic kappa light chain. Fluorescence in situ hybridization (FISH) analysis revealed del(11q22.3), but negative for t(11:14). What should be used to treat his chronic lymphocytic leukemia (CLL) disease?

Original languageEnglish (US)
Pages (from-to)90-92
Number of pages3
JournalHematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
Volume2010
StatePublished - 2010

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Lymphocytosis
Blood Cell Count
Sweat
Groin
Alkylating Agents
Splenomegaly
Leukocytosis
B-Cell Chronic Lymphocytic Leukemia
Fluorescence In Situ Hybridization
Physical Examination
Weight Loss
Fever
Lymphocytes
Light
Population
Therapeutics
Lymphadenopathy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "A 55-year-old man presented with fever, night sweats, and weight loss of about 20 lbs. in the prior 6 months. Physical examination revealed multiple cervical, axillary, and inguinal lymphadenopathy. The spleen was enlarged. A complete blood count revealed leukocytosis with absolute lymphocytosis: 30,000/μL. Peripheral blood-flow cytometric analysis showed a clonal lymphocyte population with immunophenotypes positive for CD5, CD20(dim), and monotypic kappa light chain. Fluorescence in situ hybridization (FISH) analysis revealed del(11q22.3), but negative for t(11:14). What should be used to treat his chronic lymphocytic leukemia (CLL) disease?",
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