TY - JOUR
T1 - Evaluation of the proliferative index as a prognostic factor in diffuse large cell lymphoma
T2 - Correlation with the International Index
AU - Ansell, Stephen M.
AU - Kurtin, Paul J.
AU - Stenson, Mary
AU - Habermann, Thomas M.
AU - Greipp, Philip R.
AU - Therneau, Terry M.
AU - Witzig, Thomas E.
PY - 1999
Y1 - 1999
N2 - The reasons for differences in outcome between groups of patients with diffuse large cell lymphoma (DLCL) defined by clinical prognostic factors are largely unknown. Measures of cell proliferation may offer a biological explanation for these differences. This study tested the hypothesis that these survival differences between the groups defined by established prognostic factors were due to the proliferative index. The bromodeoxyuridine labeling index (LI), a measure of the S-phase fraction, was prospectively determined on fresh tumor specimens obtained at initial diagnosis in 80 patients with DLCL seen between 1986-1993 at a single institution. Patients were grouped using prognostic factors that were signififant in a univariate analysis as well as the International Index (IPI). The LI in each of these groups was compared to determine whether the differences in outcome between the groups could be explained by differences in the LI. The median LI for all patients was 5.1% (range: 0.1-25%). When the predictive effect of the LI on response and survival was analyzed, the LI did not correlate with complete response or disease-free survival (DFS). There was a trend, however, for patients with a lower LI to have a poorer overall survival (p = 0.06). When the patients were analyzed using the International index (IPI), the mean LI for patients in the low-risk, low-intermediate, high-intermediate and high risk groups was 7.1%, 10.0%, 6.4% and 6.6% respectively (p = 0.41). When analyzed separately, there was no significant difference in the LI for any of the patient groups defined by significant prognostic factors. The only difference in the LI was that the median LI in patients with T-ceIl DLCL was significantly lower than the LI in patients with B-cell DLCL (p = 0.001) and these patients had an inferior complete response rate (p = 0.001), disease-free survival (p = 0.003) and overall survival (p = 0.015). In this study, the LI, a measure of lymphoma cell proliferation, was not a significant prognostic factor for response, disease-free survival or overall survival. Furthermore, the LI did not explain the differences in outcome between patient groups defined by the IPI. However, a lower LI seen in patients with T-cell DLCL may account for their poorer response to therapy and inferior survival when compared to patients with B-cell DLCL.
AB - The reasons for differences in outcome between groups of patients with diffuse large cell lymphoma (DLCL) defined by clinical prognostic factors are largely unknown. Measures of cell proliferation may offer a biological explanation for these differences. This study tested the hypothesis that these survival differences between the groups defined by established prognostic factors were due to the proliferative index. The bromodeoxyuridine labeling index (LI), a measure of the S-phase fraction, was prospectively determined on fresh tumor specimens obtained at initial diagnosis in 80 patients with DLCL seen between 1986-1993 at a single institution. Patients were grouped using prognostic factors that were signififant in a univariate analysis as well as the International Index (IPI). The LI in each of these groups was compared to determine whether the differences in outcome between the groups could be explained by differences in the LI. The median LI for all patients was 5.1% (range: 0.1-25%). When the predictive effect of the LI on response and survival was analyzed, the LI did not correlate with complete response or disease-free survival (DFS). There was a trend, however, for patients with a lower LI to have a poorer overall survival (p = 0.06). When the patients were analyzed using the International index (IPI), the mean LI for patients in the low-risk, low-intermediate, high-intermediate and high risk groups was 7.1%, 10.0%, 6.4% and 6.6% respectively (p = 0.41). When analyzed separately, there was no significant difference in the LI for any of the patient groups defined by significant prognostic factors. The only difference in the LI was that the median LI in patients with T-ceIl DLCL was significantly lower than the LI in patients with B-cell DLCL (p = 0.001) and these patients had an inferior complete response rate (p = 0.001), disease-free survival (p = 0.003) and overall survival (p = 0.015). In this study, the LI, a measure of lymphoma cell proliferation, was not a significant prognostic factor for response, disease-free survival or overall survival. Furthermore, the LI did not explain the differences in outcome between patient groups defined by the IPI. However, a lower LI seen in patients with T-cell DLCL may account for their poorer response to therapy and inferior survival when compared to patients with B-cell DLCL.
KW - Diffuse large cell lymphoma
KW - International Index
KW - Labeling index prognostic factors
KW - Proliferative index
UR - http://www.scopus.com/inward/record.url?scp=0032820141&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032820141&partnerID=8YFLogxK
U2 - 10.3109/10428199909058480
DO - 10.3109/10428199909058480
M3 - Article
C2 - 10492076
AN - SCOPUS:0032820141
SN - 1042-8194
VL - 34
SP - 529
EP - 537
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 5-6
ER -