Untersuchung der prognostischen Bedeutung der Tumorzellexpression von Podoplanin beim lokal fortgeschrittenen Plattenepithelkarzinom der Kopf-Hals-Region

Translated title of the contribution: Evaluation of the prognostic role of tumor cell podoplanin expression in locally advanced squamous cell carcinoma of the head and neck

Stefan Huttenlocher, Nina D. Seibold, Maximilian P. Gebhard, Frank Noack, Christoph Thorns, Katrin Hasselbacher, Barbara Wollenberg, Steven E. Schild, Dirk Rades

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Conclusion: Treatment outcomes were significantly associated with performance status, pre-RT hemoglobin level, tumor site and tumor stage. Tumor cell expression of podoplanin ≤ 10 % showed a trend towards improved OS when compared to podoplanin expression of > 10 %.

Results: In multivariate analysis, ECOG performance status 0–1 (risk ratio, RR: 3.01; 95 % confidence interval, CI: 1.42–7.14; p = 0.003), pre-RT hemoglobin levels ≥ 7.45 mmol/l (12 g/dl; RR: 2.03; 95 % CI: 1.04–3.94; p = 0.038), oropharyngeal cancer (RR: 1.25; 95 % CI: 1.01–1.55; p = 0.038) and T category T1–2 (RR: 1.81; 95 % CI: 1.24–2.79; p = 0.002) were significantly associated with improved LRC. T category T1–2 (RR: 1.90; 95 % CI: 1.25–3.06; p = 0.002) and N category N0–2a (RR: 5.22; 95 % CI: 1.96–18.09; p < 0.001) were significantly associated with better MFS. Pre-RT hemoglobin levels ≥ 7.45 mmol/l (RR: 2.44; 95 % CI: 1.27–4.74; p = 0.007), T category T1–2 (RR: 1.97; 95 % CI: 1.36–3.04; p < 0.001) and N category N0–2a (RR: 2.87; 95 % CI: 1.37–6.61; p = 0.005) were significantly associated with improved OS. Podoplanin expression ≤ 10 % showed a trend towards improved OS on both univariate (p = 0.050) and multivariate analysis (RR: 1.86; 95 % CI: 0.96–3.59; p = 0.07).

Background and purpose: To investigate the potential prognostic role of tumor cell podoplanin expression in patients treated with resection followed by irradiation or chemoradiotherapy for locally advanced squamous cell carcinoma of the head and neck (SCCHN).

Materials and methods: Podoplanin expression (≤10 % versus > 10 %) and 12 other factors were evaluated in 160 patients for their association with locoregional control (LRC), metastases-free (MFS) and overall survival (OS). Other factors were age, gender, Eastern Cooperative Oncology Group (ECOG) performance status, preradiotherapy (pre-RT) hemoglobin level, tumor site, histological grading, T category, N category, American Joint Committee on Cancer (AJCC) stage, human papillomavirus (HPV) status, extent of resection and concurrent chemotherapy.

Original languageGerman
Pages (from-to)1021-1027
Number of pages7
JournalStrahlentherapie und Onkologie
Volume190
Issue number11
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Chemoradiotherapy
  • Head and neck cancer
  • Radiotherapy
  • Resection
  • Survival

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

Huttenlocher, S., Seibold, N. D., Gebhard, M. P., Noack, F., Thorns, C., Hasselbacher, K., Wollenberg, B., Schild, S. E., & Rades, D. (2014). Untersuchung der prognostischen Bedeutung der Tumorzellexpression von Podoplanin beim lokal fortgeschrittenen Plattenepithelkarzinom der Kopf-Hals-Region. Strahlentherapie und Onkologie, 190(11), 1021-1027. https://doi.org/10.1007/s00066-014-0694-1