Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Lisa Wang; Michael G. Heckman; Jan O. Aasly; Grazia Annesi; Maria Bozi; Sun Ju Chung; Carl Clarke; David Crosiers; Gertrud Eckstein; Gaetan Garraux; Georgios M. Hadjigeorgiou; Nobu Hattori; Beom Jeon; Yun J. Kim; Masato Kubo; Suzanne Lesage; Juei Jueng Lin; Timothy Lynch; Peter Lichtner; George D. Mellick; Vincent Mok; Karin E. Morrison; Aldo Quattrone; Wataru Satake; Peter A. Silburn; Leonidas Stefanis; Joanne D. Stockton; Eng King Tan; Tatsushi Toda; Alexis Brice; Christine Van Broeckhoven; Ryan J. Uitti; Karin Wirdefeldt; Zbigniew Wszolek; Georgia Xiromerisiou; Demetrius M. Maraganore; Thomas Gasser; Rejko Krüger; Matthew J. Farrer; Owen A. Ross; Manu Sharma

doi:10.1016/j.neurobiolaging.2016.09.022

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Lisa Wang, Michael G. Heckman, Jan O. Aasly, Grazia Annesi, Maria Bozi, Sun Ju Chung, Carl Clarke, David Crosiers, Gertrud Eckstein, Gaetan Garraux, Georgios M. Hadjigeorgiou, Nobu Hattori, Beom Jeon, Yun J. Kim, Masato Kubo, Suzanne Lesage, Juei Jueng Lin, Timothy Lynch, Peter Lichtner, George D. MellickVincent Mok, Karin E. Morrison, Aldo Quattrone, Wataru Satake, Peter A. Silburn, Leonidas Stefanis, Joanne D. Stockton, Eng King Tan, Tatsushi Toda, Alexis Brice, Christine Van Broeckhoven, Ryan J. Uitti, Karin Wirdefeldt, Zbigniew Wszolek, Georgia Xiromerisiou, Demetrius M. Maraganore, Thomas Gasser, Rejko Krüger, Matthew J. Farrer, Owen A. Ross, Manu Sharma

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.

Original language	English (US)
Pages (from-to)	217.e1-217.e4
Journal	Neurobiology of aging
Volume	49
DOIs	https://doi.org/10.1016/j.neurobiolaging.2016.09.022
State	Published - Jan 1 2017

Keywords

Genetic epidemiology
LRRK2
PARK16
Parkinson's disease

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

Access to Document

10.1016/j.neurobiolaging.2016.09.022

Cite this

Wang, L., Heckman, M. G., Aasly, J. O., Annesi, G., Bozi, M., Chung, S. J., Clarke, C., Crosiers, D., Eckstein, G., Garraux, G., Hadjigeorgiou, G. M., Hattori, N., Jeon, B., Kim, Y. J., Kubo, M., Lesage, S., Lin, J. J., Lynch, T., Lichtner, P., ... Sharma, M. (2017). Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiology of aging, 49, 217.e1-217.e4. https://doi.org/10.1016/j.neurobiolaging.2016.09.022

Wang, L, Heckman, MG, Aasly, JO, Annesi, G, Bozi, M, Chung, SJ, Clarke, C, Crosiers, D, Eckstein, G, Garraux, G, Hadjigeorgiou, GM, Hattori, N, Jeon, B, Kim, YJ, Kubo, M, Lesage, S, Lin, JJ, Lynch, T, Lichtner, P, Mellick, GD, Mok, V, Morrison, KE, Quattrone, A, Satake, W, Silburn, PA, Stefanis, L, Stockton, JD, Tan, EK, Toda, T, Brice, A, Van Broeckhoven, C, Uitti, RJ, Wirdefeldt, K, Wszolek, Z, Xiromerisiou, G, Maraganore, DM, Gasser, T, Krüger, R, Farrer, MJ, Ross, OA & Sharma, M 2017, 'Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study', Neurobiology of aging, vol. 49, pp. 217.e1-217.e4. https://doi.org/10.1016/j.neurobiolaging.2016.09.022

@article{273e4478151e4dd9af95d2d047f39c5c,

title = "Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study",

abstract = "A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.",

keywords = "Genetic epidemiology, LRRK2, PARK16, Parkinson's disease",

author = "Lisa Wang and Heckman, {Michael G.} and Aasly, {Jan O.} and Grazia Annesi and Maria Bozi and Chung, {Sun Ju} and Carl Clarke and David Crosiers and Gertrud Eckstein and Gaetan Garraux and Hadjigeorgiou, {Georgios M.} and Nobu Hattori and Beom Jeon and Kim, {Yun J.} and Masato Kubo and Suzanne Lesage and Lin, {Juei Jueng} and Timothy Lynch and Peter Lichtner and Mellick, {George D.} and Vincent Mok and Morrison, {Karin E.} and Aldo Quattrone and Wataru Satake and Silburn, {Peter A.} and Leonidas Stefanis and Stockton, {Joanne D.} and Tan, {Eng King} and Tatsushi Toda and Alexis Brice and {Van Broeckhoven}, Christine and Uitti, {Ryan J.} and Karin Wirdefeldt and Zbigniew Wszolek and Georgia Xiromerisiou and Maraganore, {Demetrius M.} and Thomas Gasser and Rejko Kr{\"u}ger and Farrer, {Matthew J.} and Ross, {Owen A.} and Manu Sharma",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2017",

month = jan,

day = "1",

doi = "10.1016/j.neurobiolaging.2016.09.022",

language = "English (US)",

volume = "49",

pages = "217.e1--217.e4",

journal = "Neurobiology of aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease

T2 - analysis of a large multicenter study

AU - Wang, Lisa

AU - Heckman, Michael G.

AU - Aasly, Jan O.

AU - Annesi, Grazia

AU - Bozi, Maria

AU - Chung, Sun Ju

AU - Clarke, Carl

AU - Crosiers, David

AU - Eckstein, Gertrud

AU - Garraux, Gaetan

AU - Hadjigeorgiou, Georgios M.

AU - Hattori, Nobu

AU - Jeon, Beom

AU - Kim, Yun J.

AU - Kubo, Masato

AU - Lesage, Suzanne

AU - Lin, Juei Jueng

AU - Lynch, Timothy

AU - Lichtner, Peter

AU - Mellick, George D.

AU - Mok, Vincent

AU - Morrison, Karin E.

AU - Quattrone, Aldo

AU - Satake, Wataru

AU - Silburn, Peter A.

AU - Stefanis, Leonidas

AU - Stockton, Joanne D.

AU - Tan, Eng King

AU - Toda, Tatsushi

AU - Brice, Alexis

AU - Van Broeckhoven, Christine

AU - Uitti, Ryan J.

AU - Wirdefeldt, Karin

AU - Wszolek, Zbigniew

AU - Xiromerisiou, Georgia

AU - Maraganore, Demetrius M.

AU - Gasser, Thomas

AU - Krüger, Rejko

AU - Farrer, Matthew J.

AU - Ross, Owen A.

AU - Sharma, Manu

PY - 2017/1/1

Y1 - 2017/1/1

N2 - A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.

AB - A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.

KW - Genetic epidemiology

KW - LRRK2

KW - PARK16

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=85002145842&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85002145842&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2016.09.022

DO - 10.1016/j.neurobiolaging.2016.09.022

M3 - Article

C2 - 27814993

AN - SCOPUS:85002145842

SN - 0197-4580

VL - 49

SP - 217.e1-217.e4

JO - Neurobiology of aging

JF - Neurobiology of aging

ER -

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this