Evaluation of short-chain fatty acid enemas: Treatment of radiation proctitis

Radwan Al-Sabbagh, Frank A. Sinicrope

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Background: Radiation proctitis is a common complication of abdominal and pelvic radiotherapy; unfortunately, there is no established effective therapy for radiation proctitis. Short-chain fatty acids (SCFA) have been effectively used to treat a variety of colitides. We sought to determine whether SCFA enemas have a role in the treatment of radiation proctitis. Methods: Seven patients completed an open-labeled, pilot study to evaluate the effect of SCFA on clinical, endoscopic, and pathological parameters of radiation proctitis. Results: Four weeks of treatment with SCFA enemas resulted in clinical improvement in all patients. There were modest, but not significant, changes in endoscopic and pathological parameters. Conclusion: SCFA are a promising therapeutic option in radiation proctitis.

Original languageEnglish (US)
Pages (from-to)1814-1816
Number of pages3
JournalAmerican Journal of Gastroenterology
Issue number9
StatePublished - 1996

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Evaluation of short-chain fatty acid enemas: Treatment of radiation proctitis'. Together they form a unique fingerprint.

Cite this