Evaluation of short-chain fatty acid enemas: Treatment of radiation proctitis

Radwan Al-Sabbagh, Frank A. Sinicrope

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Background: Radiation proctitis is a common complication of abdominal and pelvic radiotherapy; unfortunately, there is no established effective therapy for radiation proctitis. Short-chain fatty acids (SCFA) have been effectively used to treat a variety of colitides. We sought to determine whether SCFA enemas have a role in the treatment of radiation proctitis. Methods: Seven patients completed an open-labeled, pilot study to evaluate the effect of SCFA on clinical, endoscopic, and pathological parameters of radiation proctitis. Results: Four weeks of treatment with SCFA enemas resulted in clinical improvement in all patients. There were modest, but not significant, changes in endoscopic and pathological parameters. Conclusion: SCFA are a promising therapeutic option in radiation proctitis.

Original languageEnglish (US)
Pages (from-to)1814-1816
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume91
Issue number9
StatePublished - Sep 26 1996

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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