Evaluation of portal venous hypertension with cine phase-contrast MR flow measurements: High association of hyperdynamic portal flow with variceal hemorrhage

David J. Burkart, C. Daniel Johnson, Richard L. Ehman, Amy L. Weaver, Duane M. Ilstrup

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Thirty-two patients with portal venous hypertension and endoscopically proved esophageal varices who were being evaluated for possible liver transplantation were studied with cine phase-contrast magnetic resonance (MR) imaging. Flow measurements in the main portal vein were obtained and associated with the presence of variceal hemorrhage within 2 years before the MR examination. Low (hypodynamic) flow was present in 22 patients, while high (hyperdynamic) flow was present in 10 patients. The presence of variceal hemorrhage was significantly associated with a high portal venous flow rate (P = .001), high variceal grade (P = .030), and Child class A or B (P = .003); however, only portal venous flow (P = .006) and variceal grade (P = .044) were found to be associated with variceal hemorrhage in a multiple logistic regression analysis. The portal venous flow rate was significantly higher among patients with Child class A or B disease compared with those with class C disease (median, 24.6 vs 8.0 mL/min·kg; P = .004).

Original languageEnglish (US)
Pages (from-to)643-648
Number of pages6
JournalRadiology
Volume188
Issue number3
DOIs
StatePublished - Sep 1993

Keywords

  • Blood, flow dynamics, 957.711
  • Esophagus, varices, 71.75
  • Hypertension, portal, 957.711
  • Liver, cirrhosis, 761.794
  • Magnetic resonance (MR), phase imaging, 957.129416, 957.12944

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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