Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

Karoline B. Kuchenbaecker, Lesley McGuffog, Daniel Barrowdale, Andrew Lee, Penny Soucy, Joe Dennis, Susan M. Domchek, Mark Robson, Amanda B. Spurdle, Susan J. Ramus, Nasim Mavaddat, Mary Beth Terry, Susan L. Neuhausen, Rita Katharina Schmutzler, Jacques Simard, Paul D.P. Pharoah, Kenneth Offit, Fergus J. Couch, Georgia Chenevix-Trench, Douglas F. EastonAntonis C. Antoniou, Sue Healey, Michael Lush, Ute Hamann, Melissa Southey, Esther M. John, Wendy K. Chung, Mary B. Daly, Saundra S. Buys, David E. Goldgar, Cecilia M. Dorfling, Elizabeth J. van Rensburg, Yuan Chun Ding, Bent Ejlertsen, Anne Marie Gerdes, Thomas V.O. Hansen, Susan Slager, Emily Hallberg, Javier Benitez, Ana Osorio, Nancy Cohen, William Lawler, Jeffrey N. Weitzel, Paolo Peterlongo, Valeria Pensotti, Riccardo Dolcetti, Monica Barile, Bernardo Bonanni, Jacopo Azzollini, Siranoush Manoukian, Bernard Peissel, Paolo Radice, Antonella Savarese, Laura Papi, Giuseppe Giannini, Florentia Fostira, Irene Konstantopoulou, Julian Adlard, Carole Brewer, Jackie Cook, Rosemarie Davidson, Diana Eccles, Ros Eeles, Steve Ellis, EMBRACE, Debra Frost, Shirley Hodgson, Louise Izatt, Fiona Lalloo, Kai ren Ong, Andrew K. Godwin, Norbert Arnold, Bernd Dworniczak, Christoph Engel, Andrea Gehrig, Eric Hahnen, Jan Hauke, Karin Kast, Alfons Meindl, Dieter Niederacher, Raymonda Varon-Mateeva, Shan Wang-Gohrke, Barbara Wappenschmidt, Laure Barjhoux, Marie Agnès Collonge-Rame, Camille Elan, Study Collaborators GEMO Study Collaborators, Lisa Golmard, Emmanuelle Barouk-Simonet, Fabienne Lesueur, Sylvie Mazoyer, Joanna Sokolowska, Dominique StoppaLyonnet, Claudine Isaacs, Kathleen B.M. Claes, Bruce Poppe, Miguel de la Hoya, Vanesa Garcia-Barberan, Kristiina Aittomäki, Heli Nevanlinna, Margreet G.E.M. Ausems, J. L. de Lange, Encarna B. Gomez Garcia, HEBON, Frans B.L. Hogervorst, Carolien M. Kets, Hanne E.J. Meijers-Heijboer, Jan C. Oosterwijk, Matti A. Rookus, Christi J. van Asperen, Ans M.W. van den Ouweland, Helena C. van Doorn, Theo A.M. van Os, Ava Kwong, Edith Olah, Orland Diez, Joan Brunet, Conxi Lazaro, Alex Teulé, Jacek Gronwald, Anna Jakubowska, Katarzyna Kaczmarek, Jan Lubinski, Grzegorz Sukiennicki, Rosa B. Barkardottir, Jocelyne Chiquette, Simona Agata, Marco Montagna, Manuel R. Teixeira, KCon Fab Investigators, Sue Kyung Park, Curtis Olswold, Marc Tischkowitz, Lenka Foretova, Pragna Gaddam, Joseph Vijai, Georg Pfeiler, Christine Rappaport-Fuerhauser, Christian F. Singer, Muy Kheng M. Tea, Mark H. Greene, Jennifer T. Loud, Gad Rennert, Evgeny N. Imyanitov, Peter J. Hulick, John L. Hays, Marion Piedmonte, Gustavo C. Rodriguez, Julie Martyn, Gord Glendon, Anna Marie Mulligan, Irene L. Andrulis, Amanda Ewart Toland, Uffe Birk Jensen, Torben A. Kruse, Inge Sokilde Pedersen, Mads Thomassen, Maria A. Caligo, Soo Hwang Teo, Raanan Berger, Eitan Friedman, Yael Laitman, Brita Arver, Ake Borg, Hans Ehrencrona, Johanna Rantala, Olufunmilayo I. Olopade, Patricia A. Ganz, Robert L. Nussbaum, Angela R. Bradbury, Katherine L. Nathanson, Banu K. Arun, Paul James, Beth Y. Karlan, Jenny Lester

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC or OC risk for BRCA1 and BRCA2 mutation carriers have not yet been assessed while their clinical management could benefit from improved personalized risk estimates. Methods: We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. Using data from 15 252 female BRCA1 and 8211 BRCA2 carriers, the association of each PRS with BC or OC risk was evaluated using a weighted cohort approach, with time to diagnosis as the outcome and estimation of the hazard ratios (HRs) per standard deviation increase in the PRS. Results: The PRS for ER-negative BC displayed the strongest association with BC risk in BRCA1 carriers (HR = 1.27, 95% confidence interval [CI] = 1.23 to 1.31, P = 8.2 × 10-53). InBRCA2 carriers, the strongest association with BC risk was seen for the overall BCPRS (HR = 1.22, 95% CI = 1.17 to 1.28, P = 7.2 × 10-20). The OC PRS was strongly associated with OC risk for both BRCA1 and BRCA2 carriers. These translate to differences in absolute risks (more than 10% in each case) between the top and bottom deciles of the PRS distribution; for example, the OC risk was 6% by age 80 years for BRCA2 carriers at the 10th percentile of the OC PRS compared with 19% risk for those at the 90th percentile of PRS. Conclusions: BC and OC PRS are predictive of cancer risk in BRCA1 and BRCA2 carriers. Incorporation of the PRS into risk prediction models has promise to better inform decisions on cancer risk management.

Original languageEnglish (US)
JournalJournal of the National Cancer Institute
Volume109
Issue number7
DOIs
StatePublished - Jul 1 2017

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Kuchenbaecker, K. B., McGuffog, L., Barrowdale, D., Lee, A., Soucy, P., Dennis, J., Domchek, S. M., Robson, M., Spurdle, A. B., Ramus, S. J., Mavaddat, N., Terry, M. B., Neuhausen, S. L., Schmutzler, R. K., Simard, J., Pharoah, P. D. P., Offit, K., Couch, F. J., Chenevix-Trench, G., ... Lester, J. (2017). Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers. Journal of the National Cancer Institute, 109(7). https://doi.org/10.1093/jnci/djw302