Evaluation of photochemical tissue bonding for closure of skin incisions and excisions

Yoko Kamegaya, William A. Farinelli, Agustina V. Vila Echague, Hirotaka Akita, Jamie Gallagher, Thomas J Flotte, R. Rox Anderson, Robert W. Redmond, Irene E. Kochevar

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Background and Objectives: Photochemical tissue bonding (PTB) is a new non-thermal technique for tissue repair involving application of a photochemically active dye and irradiation with visible light. The objective was to compare PTB with standard sutures and the tissue adhesive, octyl cyanoacrylate, for closure of skin incisions and excisions. Study Design/Materials and Methods: Incisions and excisions made on the flanks of a Hanford mini-pig were secured with subcutaneous sutures. Superficial closure methods were 3-0 monofilament sutures, PTB (Rose Bengal and green light), tissue adhesive and the combination of tissue adhesive then PTB. Wounds were evaluated 2, 4, and 6 weeks postoperatively for cosmetic outcomes and histology. Results: Cosmetic outcomes and histological scar width of incisions and excisions did not differ among the treatment groups at 2, 4, and 6 weeks. Conclusion: PTB is as effective as standard sutures for wound closure in porcine skin in terms of cosmetic outcomes and safety.

Original languageEnglish (US)
Pages (from-to)264-270
Number of pages7
JournalLasers in Surgery and Medicine
Volume37
Issue number4
DOIs
StatePublished - Oct 2005
Externally publishedYes

Fingerprint

Tissue Adhesives
Skin
Sutures
Cosmetics
Swine
Cyanoacrylates
Methyl Green
Rose Bengal
Wounds and Injuries
Cicatrix
Histology
Coloring Agents
Safety
Light
Therapeutics

Keywords

  • Excision
  • Incision
  • Lasers
  • Skin
  • Tissue repair
  • Wound closure
  • Wound healing

ASJC Scopus subject areas

  • Surgery

Cite this

Kamegaya, Y., Farinelli, W. A., Vila Echague, A. V., Akita, H., Gallagher, J., Flotte, T. J., ... Kochevar, I. E. (2005). Evaluation of photochemical tissue bonding for closure of skin incisions and excisions. Lasers in Surgery and Medicine, 37(4), 264-270. https://doi.org/10.1002/lsm.20221

Evaluation of photochemical tissue bonding for closure of skin incisions and excisions. / Kamegaya, Yoko; Farinelli, William A.; Vila Echague, Agustina V.; Akita, Hirotaka; Gallagher, Jamie; Flotte, Thomas J; Anderson, R. Rox; Redmond, Robert W.; Kochevar, Irene E.

In: Lasers in Surgery and Medicine, Vol. 37, No. 4, 10.2005, p. 264-270.

Research output: Contribution to journalArticle

Kamegaya, Y, Farinelli, WA, Vila Echague, AV, Akita, H, Gallagher, J, Flotte, TJ, Anderson, RR, Redmond, RW & Kochevar, IE 2005, 'Evaluation of photochemical tissue bonding for closure of skin incisions and excisions', Lasers in Surgery and Medicine, vol. 37, no. 4, pp. 264-270. https://doi.org/10.1002/lsm.20221
Kamegaya, Yoko ; Farinelli, William A. ; Vila Echague, Agustina V. ; Akita, Hirotaka ; Gallagher, Jamie ; Flotte, Thomas J ; Anderson, R. Rox ; Redmond, Robert W. ; Kochevar, Irene E. / Evaluation of photochemical tissue bonding for closure of skin incisions and excisions. In: Lasers in Surgery and Medicine. 2005 ; Vol. 37, No. 4. pp. 264-270.
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