Evaluation of photochemical tissue bonding for closure of skin incisions and excisions

Yoko Kamegaya; William A. Farinelli; Agustina V. Vila Echague; Hirotaka Akita; Jamie Gallagher; Thomas J. Flotte; R. Rox Anderson; Robert W. Redmond; Irene E. Kochevar

doi:10.1002/lsm.20221

Evaluation of photochemical tissue bonding for closure of skin incisions and excisions

Yoko Kamegaya, William A. Farinelli, Agustina V. Vila Echague, Hirotaka Akita, Jamie Gallagher, Thomas J. Flotte, R. Rox Anderson, Robert W. Redmond, Irene E. Kochevar

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Background and Objectives: Photochemical tissue bonding (PTB) is a new non-thermal technique for tissue repair involving application of a photochemically active dye and irradiation with visible light. The objective was to compare PTB with standard sutures and the tissue adhesive, octyl cyanoacrylate, for closure of skin incisions and excisions. Study Design/Materials and Methods: Incisions and excisions made on the flanks of a Hanford mini-pig were secured with subcutaneous sutures. Superficial closure methods were 3-0 monofilament sutures, PTB (Rose Bengal and green light), tissue adhesive and the combination of tissue adhesive then PTB. Wounds were evaluated 2, 4, and 6 weeks postoperatively for cosmetic outcomes and histology. Results: Cosmetic outcomes and histological scar width of incisions and excisions did not differ among the treatment groups at 2, 4, and 6 weeks. Conclusion: PTB is as effective as standard sutures for wound closure in porcine skin in terms of cosmetic outcomes and safety.

Original language	English (US)
Pages (from-to)	264-270
Number of pages	7
Journal	Lasers in Surgery and Medicine
Volume	37
Issue number	4
DOIs	https://doi.org/10.1002/lsm.20221
State	Published - Oct 2005

Keywords

Excision
Incision
Lasers
Skin
Tissue repair
Wound closure
Wound healing

ASJC Scopus subject areas

Surgery
Dermatology

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10.1002/lsm.20221

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title = "Evaluation of photochemical tissue bonding for closure of skin incisions and excisions",

abstract = "Background and Objectives: Photochemical tissue bonding (PTB) is a new non-thermal technique for tissue repair involving application of a photochemically active dye and irradiation with visible light. The objective was to compare PTB with standard sutures and the tissue adhesive, octyl cyanoacrylate, for closure of skin incisions and excisions. Study Design/Materials and Methods: Incisions and excisions made on the flanks of a Hanford mini-pig were secured with subcutaneous sutures. Superficial closure methods were 3-0 monofilament sutures, PTB (Rose Bengal and green light), tissue adhesive and the combination of tissue adhesive then PTB. Wounds were evaluated 2, 4, and 6 weeks postoperatively for cosmetic outcomes and histology. Results: Cosmetic outcomes and histological scar width of incisions and excisions did not differ among the treatment groups at 2, 4, and 6 weeks. Conclusion: PTB is as effective as standard sutures for wound closure in porcine skin in terms of cosmetic outcomes and safety.",

keywords = "Excision, Incision, Lasers, Skin, Tissue repair, Wound closure, Wound healing",

author = "Yoko Kamegaya and Farinelli, {William A.} and {Vila Echague}, {Agustina V.} and Hirotaka Akita and Jamie Gallagher and Flotte, {Thomas J.} and Anderson, {R. Rox} and Redmond, {Robert W.} and Kochevar, {Irene E.}",

year = "2005",

month = oct,

doi = "10.1002/lsm.20221",

language = "English (US)",

volume = "37",

pages = "264--270",

journal = "Lasers in Surgery and Medicine",

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AU - Kamegaya, Yoko

AU - Farinelli, William A.

AU - Vila Echague, Agustina V.

AU - Akita, Hirotaka

AU - Gallagher, Jamie

AU - Flotte, Thomas J.

AU - Anderson, R. Rox

AU - Redmond, Robert W.

AU - Kochevar, Irene E.

PY - 2005/10

Y1 - 2005/10

N2 - Background and Objectives: Photochemical tissue bonding (PTB) is a new non-thermal technique for tissue repair involving application of a photochemically active dye and irradiation with visible light. The objective was to compare PTB with standard sutures and the tissue adhesive, octyl cyanoacrylate, for closure of skin incisions and excisions. Study Design/Materials and Methods: Incisions and excisions made on the flanks of a Hanford mini-pig were secured with subcutaneous sutures. Superficial closure methods were 3-0 monofilament sutures, PTB (Rose Bengal and green light), tissue adhesive and the combination of tissue adhesive then PTB. Wounds were evaluated 2, 4, and 6 weeks postoperatively for cosmetic outcomes and histology. Results: Cosmetic outcomes and histological scar width of incisions and excisions did not differ among the treatment groups at 2, 4, and 6 weeks. Conclusion: PTB is as effective as standard sutures for wound closure in porcine skin in terms of cosmetic outcomes and safety.

AB - Background and Objectives: Photochemical tissue bonding (PTB) is a new non-thermal technique for tissue repair involving application of a photochemically active dye and irradiation with visible light. The objective was to compare PTB with standard sutures and the tissue adhesive, octyl cyanoacrylate, for closure of skin incisions and excisions. Study Design/Materials and Methods: Incisions and excisions made on the flanks of a Hanford mini-pig were secured with subcutaneous sutures. Superficial closure methods were 3-0 monofilament sutures, PTB (Rose Bengal and green light), tissue adhesive and the combination of tissue adhesive then PTB. Wounds were evaluated 2, 4, and 6 weeks postoperatively for cosmetic outcomes and histology. Results: Cosmetic outcomes and histological scar width of incisions and excisions did not differ among the treatment groups at 2, 4, and 6 weeks. Conclusion: PTB is as effective as standard sutures for wound closure in porcine skin in terms of cosmetic outcomes and safety.

KW - Excision

KW - Incision

KW - Lasers

KW - Skin

KW - Tissue repair

KW - Wound closure

KW - Wound healing

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Evaluation of photochemical tissue bonding for closure of skin incisions and excisions

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Keywords

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