Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy

Menahem Canetti; Mohammed W. Akhter; Amir Lerman; Ilyas S. Karaalp; Jason A. Zell; Harpreet Singh; Anilkumar Mehra; Uri Elkayam

doi:10.1016/j.amjcard.2003.08.002

Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy

Menahem Canetti, Mohammed W. Akhter, Amir Lerman, Ilyas S. Karaalp, Jason A. Zell, Harpreet Singh, Anilkumar Mehra, Uri Elkayam

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

This study demonstrates a significant impairment in coronary blood flow reserve in most patients with idiopathic dilated cardiomyopathy despite normal epicardial coronary arteries. This change may prevent appropriate increases in coronary blood flow and thus lead to myocardial ischemia and progression of disease. An association between decreased response to adenosine and acetylcholine supports previous observations indicating that adenosine-induced vasodilation of coronary microcirculation is dependent on endothelial nitric oxide production.

Original language	English (US)
Pages (from-to)	1246-1249
Number of pages	4
Journal	American Journal of Cardiology
Volume	92
Issue number	10
DOIs	https://doi.org/10.1016/j.amjcard.2003.08.002
State	Published - Nov 15 2003

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.amjcard.2003.08.002

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abstract = "This study demonstrates a significant impairment in coronary blood flow reserve in most patients with idiopathic dilated cardiomyopathy despite normal epicardial coronary arteries. This change may prevent appropriate increases in coronary blood flow and thus lead to myocardial ischemia and progression of disease. An association between decreased response to adenosine and acetylcholine supports previous observations indicating that adenosine-induced vasodilation of coronary microcirculation is dependent on endothelial nitric oxide production.",

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AU - Canetti, Menahem

AU - Akhter, Mohammed W.

AU - Lerman, Amir

AU - Karaalp, Ilyas S.

AU - Zell, Jason A.

AU - Singh, Harpreet

AU - Mehra, Anilkumar

AU - Elkayam, Uri

PY - 2003/11/15

Y1 - 2003/11/15

N2 - This study demonstrates a significant impairment in coronary blood flow reserve in most patients with idiopathic dilated cardiomyopathy despite normal epicardial coronary arteries. This change may prevent appropriate increases in coronary blood flow and thus lead to myocardial ischemia and progression of disease. An association between decreased response to adenosine and acetylcholine supports previous observations indicating that adenosine-induced vasodilation of coronary microcirculation is dependent on endothelial nitric oxide production.

AB - This study demonstrates a significant impairment in coronary blood flow reserve in most patients with idiopathic dilated cardiomyopathy despite normal epicardial coronary arteries. This change may prevent appropriate increases in coronary blood flow and thus lead to myocardial ischemia and progression of disease. An association between decreased response to adenosine and acetylcholine supports previous observations indicating that adenosine-induced vasodilation of coronary microcirculation is dependent on endothelial nitric oxide production.

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JO - American Journal of Cardiology

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ER -

Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy

Abstract

ASJC Scopus subject areas

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