Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy

Menahem Canetti, Mohammed W. Akhter, Amir Lerman, Ilyas S. Karaalp, Jason A. Zell, Harpreet Singh, Anilkumar Mehra, Uri Elkayam

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

This study demonstrates a significant impairment in coronary blood flow reserve in most patients with idiopathic dilated cardiomyopathy despite normal epicardial coronary arteries. This change may prevent appropriate increases in coronary blood flow and thus lead to myocardial ischemia and progression of disease. An association between decreased response to adenosine and acetylcholine supports previous observations indicating that adenosine-induced vasodilation of coronary microcirculation is dependent on endothelial nitric oxide production.

Original languageEnglish (US)
Pages (from-to)1246-1249
Number of pages4
JournalAmerican Journal of Cardiology
Volume92
Issue number10
DOIs
StatePublished - Nov 15 2003

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Dilated Cardiomyopathy
Adenosine
Heart Failure
Microcirculation
Vasodilation
Acetylcholine
Myocardial Ischemia
Disease Progression
Coronary Vessels
Nitric Oxide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy. / Canetti, Menahem; Akhter, Mohammed W.; Lerman, Amir; Karaalp, Ilyas S.; Zell, Jason A.; Singh, Harpreet; Mehra, Anilkumar; Elkayam, Uri.

In: American Journal of Cardiology, Vol. 92, No. 10, 15.11.2003, p. 1246-1249.

Research output: Contribution to journalArticle

Canetti, Menahem ; Akhter, Mohammed W. ; Lerman, Amir ; Karaalp, Ilyas S. ; Zell, Jason A. ; Singh, Harpreet ; Mehra, Anilkumar ; Elkayam, Uri. / Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy. In: American Journal of Cardiology. 2003 ; Vol. 92, No. 10. pp. 1246-1249.
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