TY - JOUR
T1 - Evaluation of long-term neurodevelopment in twin–twin transfusion syndrome after laser therapy
AU - Sananès, Nicolas
AU - Gabriele, Victor
AU - Weingertner, Anne Sophie
AU - Ruano, Rodrigo
AU - Sanz-Cortes, Magdalena
AU - Gaudineau, Adrien
AU - Langer, Bruno
AU - Nisand, Israël
AU - Akladios, Chérif Youssef
AU - Favre, Romain
N1 - Publisher Copyright:
© 2016 John Wiley & Sons, Ltd.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Objective: The primary objective of our study was to evaluate the long-term neurodevelopment outcome after laser surgery for twin–twin transfusion syndrome (TTTS). The secondary objective was to identify perinatal prognostic factors associated with neurodevelopmental impairment. Method: This was a single-center cohort prospective study carried out in pregnancies complicated by TTTS and treated by laser. Neurodevleopmental assesment included the administration of Ages and Stages Questionnaires® (ASQ), for the infants between 2 and 5 years of age. Results: A total of 187 patients underwent a laser for TTTS between 2004 and 2013. Significant brain lesions were detected in eight (2.9%) cases by ultrasound and/or magnetic resonance imaging including intraventricular hemorrhage, periventricular leukomalacia, and porencephaly. Questionnaires were administered to 126 children (50.4%) at 24 months or older at the moment of testing. There were 13.5% of those infants who had an abnormal ASQ (established as one area or more scoring < 2 SD) at 3.6 years ±1.3 follow-up. There was a higher rate of abnormal ASQ among the infants with a birth weight below the fifth percentile (p = 0.036). Conclusion: Twin–twin transfusion syndrome is associated with a risk of abnormal neurological development, even in case of laser surgery. Further studies are necessary to identify the risk factors for neurological impairment.
AB - Objective: The primary objective of our study was to evaluate the long-term neurodevelopment outcome after laser surgery for twin–twin transfusion syndrome (TTTS). The secondary objective was to identify perinatal prognostic factors associated with neurodevelopmental impairment. Method: This was a single-center cohort prospective study carried out in pregnancies complicated by TTTS and treated by laser. Neurodevleopmental assesment included the administration of Ages and Stages Questionnaires® (ASQ), for the infants between 2 and 5 years of age. Results: A total of 187 patients underwent a laser for TTTS between 2004 and 2013. Significant brain lesions were detected in eight (2.9%) cases by ultrasound and/or magnetic resonance imaging including intraventricular hemorrhage, periventricular leukomalacia, and porencephaly. Questionnaires were administered to 126 children (50.4%) at 24 months or older at the moment of testing. There were 13.5% of those infants who had an abnormal ASQ (established as one area or more scoring < 2 SD) at 3.6 years ±1.3 follow-up. There was a higher rate of abnormal ASQ among the infants with a birth weight below the fifth percentile (p = 0.036). Conclusion: Twin–twin transfusion syndrome is associated with a risk of abnormal neurological development, even in case of laser surgery. Further studies are necessary to identify the risk factors for neurological impairment.
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U2 - 10.1002/pd.4950
DO - 10.1002/pd.4950
M3 - Article
C2 - 27764900
AN - SCOPUS:85003550899
SN - 0197-3851
VL - 36
SP - 1139
EP - 1145
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
IS - 12
ER -