Evaluation of long-term neurodevelopment in twin–twin transfusion syndrome after laser therapy

Nicolas Sananès, Victor Gabriele, Anne Sophie Weingertner, Rodrigo Ruano, Magdalena Sanz-Cortes, Adrien Gaudineau, Bruno Langer, Israël Nisand, Chérif Youssef Akladios, Romain Favre

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The primary objective of our study was to evaluate the long-term neurodevelopment outcome after laser surgery for twin–twin transfusion syndrome (TTTS). The secondary objective was to identify perinatal prognostic factors associated with neurodevelopmental impairment. Method: This was a single-center cohort prospective study carried out in pregnancies complicated by TTTS and treated by laser. Neurodevleopmental assesment included the administration of Ages and Stages Questionnaires® (ASQ), for the infants between 2 and 5 years of age. Results: A total of 187 patients underwent a laser for TTTS between 2004 and 2013. Significant brain lesions were detected in eight (2.9%) cases by ultrasound and/or magnetic resonance imaging including intraventricular hemorrhage, periventricular leukomalacia, and porencephaly. Questionnaires were administered to 126 children (50.4%) at 24 months or older at the moment of testing. There were 13.5% of those infants who had an abnormal ASQ (established as one area or more scoring < 2 SD) at 3.6 years ±1.3 follow-up. There was a higher rate of abnormal ASQ among the infants with a birth weight below the fifth percentile (p = 0.036). Conclusion: Twin–twin transfusion syndrome is associated with a risk of abnormal neurological development, even in case of laser surgery. Further studies are necessary to identify the risk factors for neurological impairment.

Original languageEnglish (US)
Pages (from-to)1139-1145
Number of pages7
JournalPrenatal Diagnosis
Volume36
Issue number12
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Fingerprint

Laser Therapy
Lasers
Periventricular Leukomalacia
Birth Weight
Cohort Studies
Magnetic Resonance Imaging
Prospective Studies
Hemorrhage
Pregnancy
Surveys and Questionnaires
Brain

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

Cite this

Sananès, N., Gabriele, V., Weingertner, A. S., Ruano, R., Sanz-Cortes, M., Gaudineau, A., ... Favre, R. (2016). Evaluation of long-term neurodevelopment in twin–twin transfusion syndrome after laser therapy. Prenatal Diagnosis, 36(12), 1139-1145. https://doi.org/10.1002/pd.4950

Evaluation of long-term neurodevelopment in twin–twin transfusion syndrome after laser therapy. / Sananès, Nicolas; Gabriele, Victor; Weingertner, Anne Sophie; Ruano, Rodrigo; Sanz-Cortes, Magdalena; Gaudineau, Adrien; Langer, Bruno; Nisand, Israël; Akladios, Chérif Youssef; Favre, Romain.

In: Prenatal Diagnosis, Vol. 36, No. 12, 01.12.2016, p. 1139-1145.

Research output: Contribution to journalArticle

Sananès, N, Gabriele, V, Weingertner, AS, Ruano, R, Sanz-Cortes, M, Gaudineau, A, Langer, B, Nisand, I, Akladios, CY & Favre, R 2016, 'Evaluation of long-term neurodevelopment in twin–twin transfusion syndrome after laser therapy', Prenatal Diagnosis, vol. 36, no. 12, pp. 1139-1145. https://doi.org/10.1002/pd.4950
Sananès N, Gabriele V, Weingertner AS, Ruano R, Sanz-Cortes M, Gaudineau A et al. Evaluation of long-term neurodevelopment in twin–twin transfusion syndrome after laser therapy. Prenatal Diagnosis. 2016 Dec 1;36(12):1139-1145. https://doi.org/10.1002/pd.4950
Sananès, Nicolas ; Gabriele, Victor ; Weingertner, Anne Sophie ; Ruano, Rodrigo ; Sanz-Cortes, Magdalena ; Gaudineau, Adrien ; Langer, Bruno ; Nisand, Israël ; Akladios, Chérif Youssef ; Favre, Romain. / Evaluation of long-term neurodevelopment in twin–twin transfusion syndrome after laser therapy. In: Prenatal Diagnosis. 2016 ; Vol. 36, No. 12. pp. 1139-1145.
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