Evaluation of indeterminate bile duct strictures by intraductal US

Enrique Vazquez-Sequeiros, Todd H. Baron, Jonathan E. Clain, Christopher J. Gostout, Ian D. Norton, Bret Thomas Petersen, Michael J. Levy, Mary L. Jondal, Maurits J. Wiersema

Research output: Contribution to journalArticle

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Abstract

Background: Cholangiography and tissue sampling (brush cytology, biopsy) are the standard non-surgical techniques for determining whether a bile duct stricture is benign or malignant. The aim of this study was to determine whether intraductal US is of assistance in distinguishing benign from malignant biliary strictures. Methods: A retrospective review was undertaken of 30 patients with indeterminate bile duct strictures who underwent ERCP and tissue sampling from September 1999 to November 2000. A 20 MHz over-the-guidewire intraductal US catheter probe was used during ERCP for further examination of the strictures. Final diagnoses of malignant strictures (18 patients) were confirmed histopathologically; confirmation of benign stricture (12 patients) was based on negative tissue sampling plus extended clinical follow-up. Results: Based on retrospective blinded review, the diagnosis by ERCP was correct in 67% of patients, by tissue sampling in 68%, by combined ERCP/tissue sampling in 67%, and by intraductal US in 90% (p = 0.04 vs. ERCP/tissue sampling) of cases. No complication of intraductal US or ERCP was recorded. Conclusions: Intraductal US is safe and can improve on the ability at ERCP to distinguish benign from malignant biliary strictures.

Original languageEnglish (US)
Pages (from-to)372-379
Number of pages8
JournalGastrointestinal Endoscopy
Volume56
Issue number3
DOIs
StatePublished - Sep 2002

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Endoscopic Retrograde Cholangiopancreatography
Bile Ducts
Pathologic Constriction
Cholangiography
Cell Biology
Catheters
Biopsy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Vazquez-Sequeiros, E., Baron, T. H., Clain, J. E., Gostout, C. J., Norton, I. D., Petersen, B. T., ... Wiersema, M. J. (2002). Evaluation of indeterminate bile duct strictures by intraductal US. Gastrointestinal Endoscopy, 56(3), 372-379. https://doi.org/10.1067/mge.2002.126907

Evaluation of indeterminate bile duct strictures by intraductal US. / Vazquez-Sequeiros, Enrique; Baron, Todd H.; Clain, Jonathan E.; Gostout, Christopher J.; Norton, Ian D.; Petersen, Bret Thomas; Levy, Michael J.; Jondal, Mary L.; Wiersema, Maurits J.

In: Gastrointestinal Endoscopy, Vol. 56, No. 3, 09.2002, p. 372-379.

Research output: Contribution to journalArticle

Vazquez-Sequeiros, E, Baron, TH, Clain, JE, Gostout, CJ, Norton, ID, Petersen, BT, Levy, MJ, Jondal, ML & Wiersema, MJ 2002, 'Evaluation of indeterminate bile duct strictures by intraductal US', Gastrointestinal Endoscopy, vol. 56, no. 3, pp. 372-379. https://doi.org/10.1067/mge.2002.126907
Vazquez-Sequeiros E, Baron TH, Clain JE, Gostout CJ, Norton ID, Petersen BT et al. Evaluation of indeterminate bile duct strictures by intraductal US. Gastrointestinal Endoscopy. 2002 Sep;56(3):372-379. https://doi.org/10.1067/mge.2002.126907
Vazquez-Sequeiros, Enrique ; Baron, Todd H. ; Clain, Jonathan E. ; Gostout, Christopher J. ; Norton, Ian D. ; Petersen, Bret Thomas ; Levy, Michael J. ; Jondal, Mary L. ; Wiersema, Maurits J. / Evaluation of indeterminate bile duct strictures by intraductal US. In: Gastrointestinal Endoscopy. 2002 ; Vol. 56, No. 3. pp. 372-379.
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