TY - JOUR
T1 - Evaluation of indeterminate bile duct strictures by intraductal US
AU - Vazquez-Sequeiros, Enrique
AU - Baron, Todd H.
AU - Clain, Jonathan E.
AU - Gostout, Christopher J.
AU - Norton, Ian D.
AU - Petersen, Bret T.
AU - Levy, Michael J.
AU - Jondal, Mary L.
AU - Wiersema, Maurits J.
PY - 2002/9
Y1 - 2002/9
N2 - Background: Cholangiography and tissue sampling (brush cytology, biopsy) are the standard non-surgical techniques for determining whether a bile duct stricture is benign or malignant. The aim of this study was to determine whether intraductal US is of assistance in distinguishing benign from malignant biliary strictures. Methods: A retrospective review was undertaken of 30 patients with indeterminate bile duct strictures who underwent ERCP and tissue sampling from September 1999 to November 2000. A 20 MHz over-the-guidewire intraductal US catheter probe was used during ERCP for further examination of the strictures. Final diagnoses of malignant strictures (18 patients) were confirmed histopathologically; confirmation of benign stricture (12 patients) was based on negative tissue sampling plus extended clinical follow-up. Results: Based on retrospective blinded review, the diagnosis by ERCP was correct in 67% of patients, by tissue sampling in 68%, by combined ERCP/tissue sampling in 67%, and by intraductal US in 90% (p = 0.04 vs. ERCP/tissue sampling) of cases. No complication of intraductal US or ERCP was recorded. Conclusions: Intraductal US is safe and can improve on the ability at ERCP to distinguish benign from malignant biliary strictures.
AB - Background: Cholangiography and tissue sampling (brush cytology, biopsy) are the standard non-surgical techniques for determining whether a bile duct stricture is benign or malignant. The aim of this study was to determine whether intraductal US is of assistance in distinguishing benign from malignant biliary strictures. Methods: A retrospective review was undertaken of 30 patients with indeterminate bile duct strictures who underwent ERCP and tissue sampling from September 1999 to November 2000. A 20 MHz over-the-guidewire intraductal US catheter probe was used during ERCP for further examination of the strictures. Final diagnoses of malignant strictures (18 patients) were confirmed histopathologically; confirmation of benign stricture (12 patients) was based on negative tissue sampling plus extended clinical follow-up. Results: Based on retrospective blinded review, the diagnosis by ERCP was correct in 67% of patients, by tissue sampling in 68%, by combined ERCP/tissue sampling in 67%, and by intraductal US in 90% (p = 0.04 vs. ERCP/tissue sampling) of cases. No complication of intraductal US or ERCP was recorded. Conclusions: Intraductal US is safe and can improve on the ability at ERCP to distinguish benign from malignant biliary strictures.
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U2 - 10.1067/mge.2002.126907
DO - 10.1067/mge.2002.126907
M3 - Article
C2 - 12196775
AN - SCOPUS:0036740263
SN - 0016-5107
VL - 56
SP - 372
EP - 379
JO - Gastrointestinal endoscopy
JF - Gastrointestinal endoscopy
IS - 3
ER -