TY - JOUR
T1 - Evaluation of gastric emptying in familial and sporadic Parkinson disease
AU - Krygowska-Wajs, Anna
AU - Cheshire, William P.
AU - Wszolek, Zbigniew K.
AU - Hubalewska-Dydejczyk, Alicja
AU - Jasinska-Myga, Barbara
AU - Farrer, Matthew J.
AU - Moskala, Marek
AU - Sowa-Staszczak, Anna
N1 - Funding Information:
A.K-W is a Consultant on the Morris K. Udall Center of Excellence for PD Research (P50-NS40256). Z.K.W. and M.J.F are supported by the Morris K. Udall Center of Excellence for PD Research (P50-NS40256) and the Pacific Alzheimer Research Foundation (PARF) grant C06-01. B.J-M is supported by the Medical University of Silesia, Poland and the Robert and Clarice Smith Fellowship Program. The authors would like to thank Magdalena Szczerbowska-Boruchowska and Wieslaw Wajs for statistical review. Many thanks to Stephanie Cobb for her technical support. We are grateful to all patients and healthy participants for their collaborations.
PY - 2009/11/5
Y1 - 2009/11/5
N2 - Objective: To assess for the presence of gastric dysmotility in familial and sporadic Parkinson disease (PD). Methods: 10 subjects with familial Parkinson disease (fPD), 35 subjects with sporadic Parkinson disease (sPD), and 15 controls, all from academic tertiary care movement disorders centers, were studied. fPD was defined as the presence of at least 2 affected individuals within 2-3 consecutive generations in a family. Molecular genetic analysis has not revealed, thus far, any known genomic abnormality in these families. Gastric emptying was assessed by dynamic abdominal scintigraphy over 92 min following ingestion of a solid meal containing 99mTc-labeled colloid of 40 MBq activity. The main outcome measures were gastric emptying half-time and radiotracer activity over the gastric area at 46 and at 92 min. Results: Gastric emptying time was delayed in 60% of subjects with PD. In comparison to mean t1/2 of 38 ± 7 min in controls, mean t1/2 was 58 ± 25 min in fPD (p = 0.02) and 46 ± 25 min in sPD (p = 0.10). Both fPD and sPD groups included subjects with delayed gastric emptying at an early stage of disease. Conclusions: Patients with fPD showed significantly delayed gastric emptying in comparison to normal age-matched individuals. Further studies of gastrointestinal dysfunction in PD, particularly fPD, are warranted.
AB - Objective: To assess for the presence of gastric dysmotility in familial and sporadic Parkinson disease (PD). Methods: 10 subjects with familial Parkinson disease (fPD), 35 subjects with sporadic Parkinson disease (sPD), and 15 controls, all from academic tertiary care movement disorders centers, were studied. fPD was defined as the presence of at least 2 affected individuals within 2-3 consecutive generations in a family. Molecular genetic analysis has not revealed, thus far, any known genomic abnormality in these families. Gastric emptying was assessed by dynamic abdominal scintigraphy over 92 min following ingestion of a solid meal containing 99mTc-labeled colloid of 40 MBq activity. The main outcome measures were gastric emptying half-time and radiotracer activity over the gastric area at 46 and at 92 min. Results: Gastric emptying time was delayed in 60% of subjects with PD. In comparison to mean t1/2 of 38 ± 7 min in controls, mean t1/2 was 58 ± 25 min in fPD (p = 0.02) and 46 ± 25 min in sPD (p = 0.10). Both fPD and sPD groups included subjects with delayed gastric emptying at an early stage of disease. Conclusions: Patients with fPD showed significantly delayed gastric emptying in comparison to normal age-matched individuals. Further studies of gastrointestinal dysfunction in PD, particularly fPD, are warranted.
KW - Familial
KW - Gastric emptying
KW - Parkinson disease
KW - Radionuclide imaging
UR - http://www.scopus.com/inward/record.url?scp=70350191825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350191825&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2009.04.003
DO - 10.1016/j.parkreldis.2009.04.003
M3 - Article
C2 - 19451015
AN - SCOPUS:70350191825
SN - 1353-8020
VL - 15
SP - 692
EP - 696
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
IS - 9
ER -