Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression

Dirk Rades, Lukas J A Stalpers, Theo Veninga, Rainer Schulte, Peter J. Hoskin, Nermina Obralic, Amira Bajrovic, Volker Rudat, Rudolf Schwarz, Maarten C. Hulshof, Philip Poortmans, Steven E. Schild

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Abstract

Purpose: To study five radiotherapy (RT) schedules and potential prognostic factors for functional outcome in metastatic spinal cord compression (MSCC). Patients and Methods: One thousand three hundred four patients who were irradiated from January 1992 to December 2003 were included in this retrospective review. The schedules of 1 × 8 Gy in 1 day (n = 261), 5 × 4 Gy in 1 week (n = 279), 10 × 3 Gy in 2 weeks (n = 274), 15 × 2.5 Gy in 3 weeks (n = 233), and 20 × 2 Gy in 4 weeks (n = 257) were compared for motor function, ambulatory status, and in-field recurrences. The following potential prognostic factors were investigated: age, sex, performance status, histology, number of involved vertebra, interval from cancer diagnosis to MSCC, pretreatment ambulatory status, and time of developing motor deficits before RT. A multivariate analysis was performed with the ordered logit model. Results: Motor function improved in 26% (1 × 8 Gy), 28% (5 × 4 Gy), 27% (10 × 3 Gy), 31% (15 × 2.5 Gy), and 28% (20 × 2 Gy); and posttreatment ambulatory rates were 69%, 68%, 63%, 66%, and 74% (P = .578), respectively. On multivariate analysis, age, performance status, primary tumor, involved vertebra, interval from cancer diagnosis to MSCC, pretreatment ambulatory status, and time of developing motor deficits were significantly associated with functional outcome, whereas the RT schedule was not. Acute toxicity was mild, and late toxicity was not observed. In-field recurrence rates at 2 years were 24% (1 × 8 Gy), 26% (5 × 4 Gy), 14% (10 × 3 Gy), 9% (15 × 2.5 Gy), and 7% (20 × 2 Gy) (P < .001). Neither the difference between 1 × 8 Gy and 5 × 4Gy (P = .44) nor between 10 × 3 Gy, 15 × 2.5 Gy, and 20 × 2Gy (P = .71) was significant. Conclusion: The five RT schedules provided similar functional outcome. The three more protracted schedules seemed to result in fewer in-field recurrences. To minimize treatment time, the following two schedules are recommended: 1 × 8 Gy for patients with poor predicted survival and 10 × 3 Gy for other patients. Results should be confirmed in a prospective randomized trial.

Original languageEnglish (US)
Pages (from-to)3366-3375
Number of pages10
JournalJournal of Clinical Oncology
Volume23
Issue number15
DOIs
StatePublished - 2005

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Spinal Cord Compression
Appointments and Schedules
Radiation
Radiotherapy
Recurrence
Spine
Multivariate Analysis
Neoplasms
Histology
Logistic Models
Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Rades, D., Stalpers, L. J. A., Veninga, T., Schulte, R., Hoskin, P. J., Obralic, N., ... Schild, S. E. (2005). Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression. Journal of Clinical Oncology, 23(15), 3366-3375. https://doi.org/10.1200/JCO.2005.04.754

Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression. / Rades, Dirk; Stalpers, Lukas J A; Veninga, Theo; Schulte, Rainer; Hoskin, Peter J.; Obralic, Nermina; Bajrovic, Amira; Rudat, Volker; Schwarz, Rudolf; Hulshof, Maarten C.; Poortmans, Philip; Schild, Steven E.

In: Journal of Clinical Oncology, Vol. 23, No. 15, 2005, p. 3366-3375.

Research output: Contribution to journalArticle

Rades, D, Stalpers, LJA, Veninga, T, Schulte, R, Hoskin, PJ, Obralic, N, Bajrovic, A, Rudat, V, Schwarz, R, Hulshof, MC, Poortmans, P & Schild, SE 2005, 'Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression', Journal of Clinical Oncology, vol. 23, no. 15, pp. 3366-3375. https://doi.org/10.1200/JCO.2005.04.754
Rades, Dirk ; Stalpers, Lukas J A ; Veninga, Theo ; Schulte, Rainer ; Hoskin, Peter J. ; Obralic, Nermina ; Bajrovic, Amira ; Rudat, Volker ; Schwarz, Rudolf ; Hulshof, Maarten C. ; Poortmans, Philip ; Schild, Steven E. / Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression. In: Journal of Clinical Oncology. 2005 ; Vol. 23, No. 15. pp. 3366-3375.
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abstract = "Purpose: To study five radiotherapy (RT) schedules and potential prognostic factors for functional outcome in metastatic spinal cord compression (MSCC). Patients and Methods: One thousand three hundred four patients who were irradiated from January 1992 to December 2003 were included in this retrospective review. The schedules of 1 × 8 Gy in 1 day (n = 261), 5 × 4 Gy in 1 week (n = 279), 10 × 3 Gy in 2 weeks (n = 274), 15 × 2.5 Gy in 3 weeks (n = 233), and 20 × 2 Gy in 4 weeks (n = 257) were compared for motor function, ambulatory status, and in-field recurrences. The following potential prognostic factors were investigated: age, sex, performance status, histology, number of involved vertebra, interval from cancer diagnosis to MSCC, pretreatment ambulatory status, and time of developing motor deficits before RT. A multivariate analysis was performed with the ordered logit model. Results: Motor function improved in 26{\%} (1 × 8 Gy), 28{\%} (5 × 4 Gy), 27{\%} (10 × 3 Gy), 31{\%} (15 × 2.5 Gy), and 28{\%} (20 × 2 Gy); and posttreatment ambulatory rates were 69{\%}, 68{\%}, 63{\%}, 66{\%}, and 74{\%} (P = .578), respectively. On multivariate analysis, age, performance status, primary tumor, involved vertebra, interval from cancer diagnosis to MSCC, pretreatment ambulatory status, and time of developing motor deficits were significantly associated with functional outcome, whereas the RT schedule was not. Acute toxicity was mild, and late toxicity was not observed. In-field recurrence rates at 2 years were 24{\%} (1 × 8 Gy), 26{\%} (5 × 4 Gy), 14{\%} (10 × 3 Gy), 9{\%} (15 × 2.5 Gy), and 7{\%} (20 × 2 Gy) (P < .001). Neither the difference between 1 × 8 Gy and 5 × 4Gy (P = .44) nor between 10 × 3 Gy, 15 × 2.5 Gy, and 20 × 2Gy (P = .71) was significant. Conclusion: The five RT schedules provided similar functional outcome. The three more protracted schedules seemed to result in fewer in-field recurrences. To minimize treatment time, the following two schedules are recommended: 1 × 8 Gy for patients with poor predicted survival and 10 × 3 Gy for other patients. Results should be confirmed in a prospective randomized trial.",
author = "Dirk Rades and Stalpers, {Lukas J A} and Theo Veninga and Rainer Schulte and Hoskin, {Peter J.} and Nermina Obralic and Amira Bajrovic and Volker Rudat and Rudolf Schwarz and Hulshof, {Maarten C.} and Philip Poortmans and Schild, {Steven E.}",
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T1 - Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression

AU - Rades, Dirk

AU - Stalpers, Lukas J A

AU - Veninga, Theo

AU - Schulte, Rainer

AU - Hoskin, Peter J.

AU - Obralic, Nermina

AU - Bajrovic, Amira

AU - Rudat, Volker

AU - Schwarz, Rudolf

AU - Hulshof, Maarten C.

AU - Poortmans, Philip

AU - Schild, Steven E.

PY - 2005

Y1 - 2005

N2 - Purpose: To study five radiotherapy (RT) schedules and potential prognostic factors for functional outcome in metastatic spinal cord compression (MSCC). Patients and Methods: One thousand three hundred four patients who were irradiated from January 1992 to December 2003 were included in this retrospective review. The schedules of 1 × 8 Gy in 1 day (n = 261), 5 × 4 Gy in 1 week (n = 279), 10 × 3 Gy in 2 weeks (n = 274), 15 × 2.5 Gy in 3 weeks (n = 233), and 20 × 2 Gy in 4 weeks (n = 257) were compared for motor function, ambulatory status, and in-field recurrences. The following potential prognostic factors were investigated: age, sex, performance status, histology, number of involved vertebra, interval from cancer diagnosis to MSCC, pretreatment ambulatory status, and time of developing motor deficits before RT. A multivariate analysis was performed with the ordered logit model. Results: Motor function improved in 26% (1 × 8 Gy), 28% (5 × 4 Gy), 27% (10 × 3 Gy), 31% (15 × 2.5 Gy), and 28% (20 × 2 Gy); and posttreatment ambulatory rates were 69%, 68%, 63%, 66%, and 74% (P = .578), respectively. On multivariate analysis, age, performance status, primary tumor, involved vertebra, interval from cancer diagnosis to MSCC, pretreatment ambulatory status, and time of developing motor deficits were significantly associated with functional outcome, whereas the RT schedule was not. Acute toxicity was mild, and late toxicity was not observed. In-field recurrence rates at 2 years were 24% (1 × 8 Gy), 26% (5 × 4 Gy), 14% (10 × 3 Gy), 9% (15 × 2.5 Gy), and 7% (20 × 2 Gy) (P < .001). Neither the difference between 1 × 8 Gy and 5 × 4Gy (P = .44) nor between 10 × 3 Gy, 15 × 2.5 Gy, and 20 × 2Gy (P = .71) was significant. Conclusion: The five RT schedules provided similar functional outcome. The three more protracted schedules seemed to result in fewer in-field recurrences. To minimize treatment time, the following two schedules are recommended: 1 × 8 Gy for patients with poor predicted survival and 10 × 3 Gy for other patients. Results should be confirmed in a prospective randomized trial.

AB - Purpose: To study five radiotherapy (RT) schedules and potential prognostic factors for functional outcome in metastatic spinal cord compression (MSCC). Patients and Methods: One thousand three hundred four patients who were irradiated from January 1992 to December 2003 were included in this retrospective review. The schedules of 1 × 8 Gy in 1 day (n = 261), 5 × 4 Gy in 1 week (n = 279), 10 × 3 Gy in 2 weeks (n = 274), 15 × 2.5 Gy in 3 weeks (n = 233), and 20 × 2 Gy in 4 weeks (n = 257) were compared for motor function, ambulatory status, and in-field recurrences. The following potential prognostic factors were investigated: age, sex, performance status, histology, number of involved vertebra, interval from cancer diagnosis to MSCC, pretreatment ambulatory status, and time of developing motor deficits before RT. A multivariate analysis was performed with the ordered logit model. Results: Motor function improved in 26% (1 × 8 Gy), 28% (5 × 4 Gy), 27% (10 × 3 Gy), 31% (15 × 2.5 Gy), and 28% (20 × 2 Gy); and posttreatment ambulatory rates were 69%, 68%, 63%, 66%, and 74% (P = .578), respectively. On multivariate analysis, age, performance status, primary tumor, involved vertebra, interval from cancer diagnosis to MSCC, pretreatment ambulatory status, and time of developing motor deficits were significantly associated with functional outcome, whereas the RT schedule was not. Acute toxicity was mild, and late toxicity was not observed. In-field recurrence rates at 2 years were 24% (1 × 8 Gy), 26% (5 × 4 Gy), 14% (10 × 3 Gy), 9% (15 × 2.5 Gy), and 7% (20 × 2 Gy) (P < .001). Neither the difference between 1 × 8 Gy and 5 × 4Gy (P = .44) nor between 10 × 3 Gy, 15 × 2.5 Gy, and 20 × 2Gy (P = .71) was significant. Conclusion: The five RT schedules provided similar functional outcome. The three more protracted schedules seemed to result in fewer in-field recurrences. To minimize treatment time, the following two schedules are recommended: 1 × 8 Gy for patients with poor predicted survival and 10 × 3 Gy for other patients. Results should be confirmed in a prospective randomized trial.

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