Evaluation of familial clustering of breast and prostate cancer in the Minnesota Breast Cancer Family Study

Dawn M. Grabrick, James R Cerhan, Robert A. Vierkant, Terry M Therneau, John C. Cheville, Donald J. Tindall, Thomas A. Sellers

Research output: Contribution to journalArticle

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Abstract

Few studies examining familial clustering of breast and prostate cancer (PC) have focused on a clearly defined high-risk population with epidemiologic risk factors. We conducted a cohort study of prostate cancer among a subset of 426 families ascertained through female breast cancer probands. Three groups of males were included: 804 relatives in 60 families with four or more breast or ovarian cancers, 536 marry-ins in these high-risk families, and 484 relatives in 81 families where only the proband had breast cancer. A total of 118 prostate cancers were reported. The rate of prostate cancer among blood relatives in high-risk families was significantly lower than among marry-ins (RR = 0.6, 95% C.I.: 0.4-0.9). The rate of prostate cancer among blood relatives in low-risk families was not significantly different from the rate among marry-ins (RR = 0.8, 95% C.I.: 0.5-1.2). These results provide little evidence that male relatives in high-risk breast cancer families are at increased risk of prostate cancer.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalCancer Detection and Prevention
Volume27
Issue number1
DOIs
StatePublished - 2003

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Cluster Analysis
Prostatic Neoplasms
Breast Neoplasms
Epidemiologic Factors
Ovarian Neoplasms
Familial Prostate cancer
Familial Breast Cancer
Cohort Studies
Population

Keywords

  • Breast cancer
  • Familial aggregation
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Evaluation of familial clustering of breast and prostate cancer in the Minnesota Breast Cancer Family Study. / Grabrick, Dawn M.; Cerhan, James R; Vierkant, Robert A.; Therneau, Terry M; Cheville, John C.; Tindall, Donald J.; Sellers, Thomas A.

In: Cancer Detection and Prevention, Vol. 27, No. 1, 2003, p. 30-36.

Research output: Contribution to journalArticle

Grabrick, Dawn M. ; Cerhan, James R ; Vierkant, Robert A. ; Therneau, Terry M ; Cheville, John C. ; Tindall, Donald J. ; Sellers, Thomas A. / Evaluation of familial clustering of breast and prostate cancer in the Minnesota Breast Cancer Family Study. In: Cancer Detection and Prevention. 2003 ; Vol. 27, No. 1. pp. 30-36.
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