Abstract
Few studies examining familial clustering of breast and prostate cancer (PC) have focused on a clearly defined high-risk population with epidemiologic risk factors. We conducted a cohort study of prostate cancer among a subset of 426 families ascertained through female breast cancer probands. Three groups of males were included: 804 relatives in 60 families with four or more breast or ovarian cancers, 536 marry-ins in these high-risk families, and 484 relatives in 81 families where only the proband had breast cancer. A total of 118 prostate cancers were reported. The rate of prostate cancer among blood relatives in high-risk families was significantly lower than among marry-ins (RR = 0.6, 95% C.I.: 0.4-0.9). The rate of prostate cancer among blood relatives in low-risk families was not significantly different from the rate among marry-ins (RR = 0.8, 95% C.I.: 0.5-1.2). These results provide little evidence that male relatives in high-risk breast cancer families are at increased risk of prostate cancer.
Original language | English (US) |
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Pages (from-to) | 30-36 |
Number of pages | 7 |
Journal | Cancer Detection and Prevention |
Volume | 27 |
Issue number | 1 |
DOIs | |
State | Published - 2003 |
Keywords
- Breast cancer
- Familial aggregation
- Prostate cancer
ASJC Scopus subject areas
- Oncology
- Cancer Research