Evaluation of electrochemical methods for tonic dopamine detection in vivo

Aaron E. Rusheen, Taylor A. Gee, Dong P. Jang, Charles D. Blaha, Kevin E. Bennet, Kendall H. Lee, Michael L. Heien, Yoonbae Oh

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Dysfunction in dopaminergic neuronal systems underlie a number of neurologic and psychiatric disorders such as Parkinson's disease, drug addiction, and schizophrenia. Dopamine systems communicate via two mechanisms, a fast “phasic” release (sub-second to second) that is related to salient stimuli and a slower “tonic” release (minutes to hours) that regulates receptor tone. Alterations in tonic levels are thought to be more critically important in enabling normal motor, cognitive, and motivational functions, and dysregulation in tonic dopamine levels are associated with neuropsychiatric disorders. Therefore, development of neurochemical recording techniques that enable rapid, selective, and quantitative measurements of changes in tonic extracellular levels are essential in determining the role of dopamine in both normal and disease states. Here, we review state-of-the-art advanced analytical techniques for in vivo detection of tonic levels, with special focus on electrochemical techniques for detection in humans.

Original languageEnglish (US)
Article number116049
JournalTrAC - Trends in Analytical Chemistry
Volume132
DOIs
StatePublished - Nov 2020

Keywords

  • Dopamine
  • Electrochemistry
  • Neurochemistry
  • Sensors
  • Tonic dopamine
  • Voltammetry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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