Evaluation of caspofungin and amphotericin B deoxycholate against Candida albicans biofilms in an experimental intravascular catheter infection model

Jennifer A. Shuford, Mark S. Rouse, Kerryl E. Piper, James M. Steckelberg, Robin Patel

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Candida albicans biofilms complicate the treatment of infected implanted intravascular devices because of decreased antifungal susceptibility. In our investigation, 48 rabbits with experimental central venous catheter C. albicans infection were equally allocated to a control arm or to receive amphotericin B deoxycholate or caspofungin treatment while undergoing systemic and intraluminal lock therapy for 7 days. C. albicans was cultured from catheters from all control rabbits, from 3 that received amphotericin B, and from 0 that received caspofungin. Differences in colony counts were detected between the control and amphotericin (P<.001) and control and caspofungin (P<.001) arms. Caspofungin may be useful in the treatment of C. albicans biofilm-associated intravascular catheter infections, which warrants further study.

Original languageEnglish (US)
Pages (from-to)710-713
Number of pages4
JournalJournal of Infectious Diseases
Volume194
Issue number5
DOIs
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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