Abstract
Candida albicans biofilms complicate the treatment of infected implanted intravascular devices because of decreased antifungal susceptibility. In our investigation, 48 rabbits with experimental central venous catheter C. albicans infection were equally allocated to a control arm or to receive amphotericin B deoxycholate or caspofungin treatment while undergoing systemic and intraluminal lock therapy for 7 days. C. albicans was cultured from catheters from all control rabbits, from 3 that received amphotericin B, and from 0 that received caspofungin. Differences in colony counts were detected between the control and amphotericin (P<.001) and control and caspofungin (P<.001) arms. Caspofungin may be useful in the treatment of C. albicans biofilm-associated intravascular catheter infections, which warrants further study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 710-713 |
| Number of pages | 4 |
| Journal | Journal of Infectious Diseases |
| Volume | 194 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 1 2006 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
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Evaluation of caspofungin and amphotericin B deoxycholate against Candida albicans biofilms in an experimental intravascular catheter infection model. / Shuford, Jennifer A.; Rouse, Mark S.; Piper, Kerryl E.; Steckelberg, James M.; Patel, Robin.
In: Journal of Infectious Diseases, Vol. 194, No. 5, 01.09.2006, p. 710-713.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of caspofungin and amphotericin B deoxycholate against Candida albicans biofilms in an experimental intravascular catheter infection model
AU - Shuford, Jennifer A.
AU - Rouse, Mark S.
AU - Piper, Kerryl E.
AU - Steckelberg, James M.
AU - Patel, Robin
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Candida albicans biofilms complicate the treatment of infected implanted intravascular devices because of decreased antifungal susceptibility. In our investigation, 48 rabbits with experimental central venous catheter C. albicans infection were equally allocated to a control arm or to receive amphotericin B deoxycholate or caspofungin treatment while undergoing systemic and intraluminal lock therapy for 7 days. C. albicans was cultured from catheters from all control rabbits, from 3 that received amphotericin B, and from 0 that received caspofungin. Differences in colony counts were detected between the control and amphotericin (P<.001) and control and caspofungin (P<.001) arms. Caspofungin may be useful in the treatment of C. albicans biofilm-associated intravascular catheter infections, which warrants further study.
AB - Candida albicans biofilms complicate the treatment of infected implanted intravascular devices because of decreased antifungal susceptibility. In our investigation, 48 rabbits with experimental central venous catheter C. albicans infection were equally allocated to a control arm or to receive amphotericin B deoxycholate or caspofungin treatment while undergoing systemic and intraluminal lock therapy for 7 days. C. albicans was cultured from catheters from all control rabbits, from 3 that received amphotericin B, and from 0 that received caspofungin. Differences in colony counts were detected between the control and amphotericin (P<.001) and control and caspofungin (P<.001) arms. Caspofungin may be useful in the treatment of C. albicans biofilm-associated intravascular catheter infections, which warrants further study.
UR - http://www.scopus.com/inward/record.url?scp=33748035709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748035709&partnerID=8YFLogxK
U2 - 10.1086/506452
DO - 10.1086/506452
M3 - Article
VL - 194
SP - 710
EP - 713
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 5
ER -