Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients

W. Ray Kim; Thomas Berg; Tarik Asselah; Robert Flisiak; Scott Fung; Stuart C. Gordon; Harry L A Janssen; Pietro Lampertico; Daryl Lau; Jeffrey D. Bornstein; Raul E Aguilar Schall; Phillip Dinh; Leland J. Yee; Eduardo B. Martins; Seng Gee Lim; Rohit Loomba; Jörg Petersen; Maria Buti; Patrick Marcellin

doi:10.1016/j.jhep.2015.11.012

Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients

W. Ray Kim, Thomas Berg, Tarik Asselah, Robert Flisiak, Scott Fung, Stuart C. Gordon, Harry L A Janssen, Pietro Lampertico, Daryl Lau, Jeffrey D. Bornstein, Raul E Aguilar Schall, Phillip Dinh, Leland J. Yee, Eduardo B. Martins, Seng Gee Lim, Rohit Loomba, Jörg Petersen, Maria Buti, Patrick Marcellin

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Background & Aims: While the gold standard in the assessment of liver fibrosis remains liver biopsy, non-invasive methods have been increasingly used for chronic hepatitis B (CHB). This study aimed to evaluate the performance of two commonly used non-invasive scoring systems (aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4)) to predict fibrosis stage in CHB patients. Materials and methods: Demographic, histologic and clinical laboratory data from two trials investigating tenofovir disoproxil fumarate in CHB were analyzed. Predicted fibrosis stage, based on established scales and cut-off values for APRI and FIB-4 scores, was compared with Ishak scores obtained from liver biopsy at baseline and at 240. week follow-up. Results: In the 575 patients with a baseline liver biopsy, APRI and FIB-4 scores correlated with Ishak stage (p

Original language	English (US)
Journal	Journal of Hepatology
DOIs	https://doi.org/10.1016/j.jhep.2015.11.012
State	Accepted/In press - May 21 2015
Externally published	Yes

Keywords

APRI
Chronic hepatitis B
FIB-4
Fibrosis

ASJC Scopus subject areas

Hepatology

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Ray Kim, W., Berg, T., Asselah, T., Flisiak, R., Fung, S., Gordon, S. C., Janssen, H. L. A., Lampertico, P., Lau, D., Bornstein, J. D., Schall, R. E. A., Dinh, P., Yee, L. J., Martins, E. B., Lim, S. G., Loomba, R., Petersen, J., Buti, M., & Marcellin, P. (Accepted/In press). Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2015.11.012

Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients. / Ray Kim, W.; Berg, Thomas; Asselah, Tarik; Flisiak, Robert; Fung, Scott; Gordon, Stuart C.; Janssen, Harry L A; Lampertico, Pietro; Lau, Daryl; Bornstein, Jeffrey D.; Schall, Raul E Aguilar; Dinh, Phillip; Yee, Leland J.; Martins, Eduardo B.; Lim, Seng Gee; Loomba, Rohit; Petersen, Jörg; Buti, Maria; Marcellin, Patrick.

In: Journal of Hepatology, 21.05.2015.

Research output: Contribution to journal › Article › peer-review

Ray Kim, W, Berg, T, Asselah, T, Flisiak, R, Fung, S, Gordon, SC, Janssen, HLA, Lampertico, P, Lau, D, Bornstein, JD, Schall, REA, Dinh, P, Yee, LJ, Martins, EB, Lim, SG, Loomba, R, Petersen, J, Buti, M & Marcellin, P 2015, 'Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients', Journal of Hepatology. https://doi.org/10.1016/j.jhep.2015.11.012

Ray Kim, W. ; Berg, Thomas ; Asselah, Tarik ; Flisiak, Robert ; Fung, Scott ; Gordon, Stuart C. ; Janssen, Harry L A ; Lampertico, Pietro ; Lau, Daryl ; Bornstein, Jeffrey D. ; Schall, Raul E Aguilar ; Dinh, Phillip ; Yee, Leland J. ; Martins, Eduardo B. ; Lim, Seng Gee ; Loomba, Rohit ; Petersen, Jörg ; Buti, Maria ; Marcellin, Patrick. / Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients. In: Journal of Hepatology. 2015.

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title = "Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients",

abstract = "Background & Aims: While the gold standard in the assessment of liver fibrosis remains liver biopsy, non-invasive methods have been increasingly used for chronic hepatitis B (CHB). This study aimed to evaluate the performance of two commonly used non-invasive scoring systems (aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4)) to predict fibrosis stage in CHB patients. Materials and methods: Demographic, histologic and clinical laboratory data from two trials investigating tenofovir disoproxil fumarate in CHB were analyzed. Predicted fibrosis stage, based on established scales and cut-off values for APRI and FIB-4 scores, was compared with Ishak scores obtained from liver biopsy at baseline and at 240. week follow-up. Results: In the 575 patients with a baseline liver biopsy, APRI and FIB-4 scores correlated with Ishak stage (p ",

keywords = "APRI, Chronic hepatitis B, FIB-4, Fibrosis",

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doi = "10.1016/j.jhep.2015.11.012",

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AU - Ray Kim, W.

AU - Berg, Thomas

AU - Asselah, Tarik

AU - Flisiak, Robert

AU - Fung, Scott

AU - Gordon, Stuart C.

AU - Janssen, Harry L A

AU - Lampertico, Pietro

AU - Lau, Daryl

AU - Bornstein, Jeffrey D.

AU - Schall, Raul E Aguilar

AU - Dinh, Phillip

AU - Yee, Leland J.

AU - Martins, Eduardo B.

AU - Lim, Seng Gee

AU - Loomba, Rohit

AU - Petersen, Jörg

AU - Buti, Maria

AU - Marcellin, Patrick

PY - 2015/5/21

Y1 - 2015/5/21

N2 - Background & Aims: While the gold standard in the assessment of liver fibrosis remains liver biopsy, non-invasive methods have been increasingly used for chronic hepatitis B (CHB). This study aimed to evaluate the performance of two commonly used non-invasive scoring systems (aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4)) to predict fibrosis stage in CHB patients. Materials and methods: Demographic, histologic and clinical laboratory data from two trials investigating tenofovir disoproxil fumarate in CHB were analyzed. Predicted fibrosis stage, based on established scales and cut-off values for APRI and FIB-4 scores, was compared with Ishak scores obtained from liver biopsy at baseline and at 240. week follow-up. Results: In the 575 patients with a baseline liver biopsy, APRI and FIB-4 scores correlated with Ishak stage (p

AB - Background & Aims: While the gold standard in the assessment of liver fibrosis remains liver biopsy, non-invasive methods have been increasingly used for chronic hepatitis B (CHB). This study aimed to evaluate the performance of two commonly used non-invasive scoring systems (aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4)) to predict fibrosis stage in CHB patients. Materials and methods: Demographic, histologic and clinical laboratory data from two trials investigating tenofovir disoproxil fumarate in CHB were analyzed. Predicted fibrosis stage, based on established scales and cut-off values for APRI and FIB-4 scores, was compared with Ishak scores obtained from liver biopsy at baseline and at 240. week follow-up. Results: In the 575 patients with a baseline liver biopsy, APRI and FIB-4 scores correlated with Ishak stage (p

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