Abstract
Background & Aims: While the gold standard in the assessment of liver fibrosis remains liver biopsy, non-invasive methods have been increasingly used for chronic hepatitis B (CHB). This study aimed to evaluate the performance of two commonly used non-invasive scoring systems (aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4)) to predict fibrosis stage in CHB patients. Materials and methods: Demographic, histologic and clinical laboratory data from two trials investigating tenofovir disoproxil fumarate in CHB were analyzed. Predicted fibrosis stage, based on established scales and cut-off values for APRI and FIB-4 scores, was compared with Ishak scores obtained from liver biopsy at baseline and at 240. week follow-up. Results: In the 575 patients with a baseline liver biopsy, APRI and FIB-4 scores correlated with Ishak stage (p
| Original language | English (US) |
|---|---|
| Journal | Journal of Hepatology |
| DOIs | |
| State | Accepted/In press - May 21 2015 |
| Externally published | Yes |
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Keywords
- APRI
- Chronic hepatitis B
- FIB-4
- Fibrosis
ASJC Scopus subject areas
- Hepatology
Cite this
Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients. / Ray Kim, W.; Berg, Thomas; Asselah, Tarik; Flisiak, Robert; Fung, Scott; Gordon, Stuart C.; Janssen, Harry L A; Lampertico, Pietro; Lau, Daryl; Bornstein, Jeffrey D.; Schall, Raul E Aguilar; Dinh, Phillip; Yee, Leland J.; Martins, Eduardo B.; Lim, Seng Gee; Loomba, Rohit; Petersen, Jörg; Buti, Maria; Marcellin, Patrick.
In: Journal of Hepatology, 21.05.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients
AU - Ray Kim, W.
AU - Berg, Thomas
AU - Asselah, Tarik
AU - Flisiak, Robert
AU - Fung, Scott
AU - Gordon, Stuart C.
AU - Janssen, Harry L A
AU - Lampertico, Pietro
AU - Lau, Daryl
AU - Bornstein, Jeffrey D.
AU - Schall, Raul E Aguilar
AU - Dinh, Phillip
AU - Yee, Leland J.
AU - Martins, Eduardo B.
AU - Lim, Seng Gee
AU - Loomba, Rohit
AU - Petersen, Jörg
AU - Buti, Maria
AU - Marcellin, Patrick
PY - 2015/5/21
Y1 - 2015/5/21
N2 - Background & Aims: While the gold standard in the assessment of liver fibrosis remains liver biopsy, non-invasive methods have been increasingly used for chronic hepatitis B (CHB). This study aimed to evaluate the performance of two commonly used non-invasive scoring systems (aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4)) to predict fibrosis stage in CHB patients. Materials and methods: Demographic, histologic and clinical laboratory data from two trials investigating tenofovir disoproxil fumarate in CHB were analyzed. Predicted fibrosis stage, based on established scales and cut-off values for APRI and FIB-4 scores, was compared with Ishak scores obtained from liver biopsy at baseline and at 240. week follow-up. Results: In the 575 patients with a baseline liver biopsy, APRI and FIB-4 scores correlated with Ishak stage (p
AB - Background & Aims: While the gold standard in the assessment of liver fibrosis remains liver biopsy, non-invasive methods have been increasingly used for chronic hepatitis B (CHB). This study aimed to evaluate the performance of two commonly used non-invasive scoring systems (aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4)) to predict fibrosis stage in CHB patients. Materials and methods: Demographic, histologic and clinical laboratory data from two trials investigating tenofovir disoproxil fumarate in CHB were analyzed. Predicted fibrosis stage, based on established scales and cut-off values for APRI and FIB-4 scores, was compared with Ishak scores obtained from liver biopsy at baseline and at 240. week follow-up. Results: In the 575 patients with a baseline liver biopsy, APRI and FIB-4 scores correlated with Ishak stage (p
KW - APRI
KW - Chronic hepatitis B
KW - FIB-4
KW - Fibrosis
UR - http://www.scopus.com/inward/record.url?scp=84957066037&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957066037&partnerID=8YFLogxK
U2 - 10.1016/j.jhep.2015.11.012
DO - 10.1016/j.jhep.2015.11.012
M3 - Article
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
ER -