Abstract
Background: Automated external defibrillators can provide life-saving therapies to treat ventricular fibrillation. We developed a prototype unit that can deliver a unique shock waveform produced by four independent capacitors that is delivered through two shock vectors, with the rationale of providing more robust shock pathways during emergent defibrillation. We describe the initial testing and feasibility of this unique defibrillation unit, features of which may enable downsizing of current defibrillator devices. Methods: We tested our defibrillation unit in four large animal models (two canine and two swine) under general anesthesia. Experimental defibrillation thresholds (DFT) were obtained by delivery of a unique waveform shock pulse via a dual-vector pathway with four defibrillation pads (placed across the chest). DFTs were measured and compared with those of a commercially available biphasic defibrillator (Zoll M series, Zoll Medical, Chelmsford, MA, USA) tested in two different vectors. Shocks were delivered after 10 seconds of stable ventricular fibrillation and the output characteristics and shock outcome recorded. Each defibrillation series used a step-down to failure protocol to define the defibrillation threshold. Results: A total of 96 shocks were delivered during ventricular fibrillation in four large animals. In comparison to the Zoll M series, which delivered a single-vector, biphasic shock, the energy required for successful defibrillation using the unique dual-vector biphasic waveform did not differ significantly (P = 0.65). Conclusions: Our early findings support the feasibility of a unique external defibrillation unit using a dual-vector biphasic waveform approach. This warrants further study to leverage this unique concept and work toward a miniaturized, portable shock delivery system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 108-114 |
| Number of pages | 7 |
| Journal | PACE - Pacing and Clinical Electrophysiology |
| Volume | 40 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2017 |
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Keywords
- defibrillator
- dual-vector biphasic shock waveform
- miniaturized
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Evaluation of a Unique Defibrillation Unit with Dual-Vector Biphasic Waveform Capabilities : Towards a Miniaturized Defibrillator. / Okamura, Hideo; Desimone, Christopher V.; Killu, Ammar M.; Gilles, Emily J.; Tri, Jason; Asirvatham, Roshini; Ladewig, Dejae J.; Suddendorf, Scott H.; Powers, Joanne M.; Wood-Wentz, Christina M.; Gray, Peter D.; Raymond, Douglas M.; Savage, Shelley J.; Savage, Walter T.; Bruce, Charles J; Asirvatham, Samuel J; Friedman, Paul Andrew.
In: PACE - Pacing and Clinical Electrophysiology, Vol. 40, No. 2, 01.02.2017, p. 108-114.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of a Unique Defibrillation Unit with Dual-Vector Biphasic Waveform Capabilities
T2 - Towards a Miniaturized Defibrillator
AU - Okamura, Hideo
AU - Desimone, Christopher V.
AU - Killu, Ammar M.
AU - Gilles, Emily J.
AU - Tri, Jason
AU - Asirvatham, Roshini
AU - Ladewig, Dejae J.
AU - Suddendorf, Scott H.
AU - Powers, Joanne M.
AU - Wood-Wentz, Christina M.
AU - Gray, Peter D.
AU - Raymond, Douglas M.
AU - Savage, Shelley J.
AU - Savage, Walter T.
AU - Bruce, Charles J
AU - Asirvatham, Samuel J
AU - Friedman, Paul Andrew
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Background: Automated external defibrillators can provide life-saving therapies to treat ventricular fibrillation. We developed a prototype unit that can deliver a unique shock waveform produced by four independent capacitors that is delivered through two shock vectors, with the rationale of providing more robust shock pathways during emergent defibrillation. We describe the initial testing and feasibility of this unique defibrillation unit, features of which may enable downsizing of current defibrillator devices. Methods: We tested our defibrillation unit in four large animal models (two canine and two swine) under general anesthesia. Experimental defibrillation thresholds (DFT) were obtained by delivery of a unique waveform shock pulse via a dual-vector pathway with four defibrillation pads (placed across the chest). DFTs were measured and compared with those of a commercially available biphasic defibrillator (Zoll M series, Zoll Medical, Chelmsford, MA, USA) tested in two different vectors. Shocks were delivered after 10 seconds of stable ventricular fibrillation and the output characteristics and shock outcome recorded. Each defibrillation series used a step-down to failure protocol to define the defibrillation threshold. Results: A total of 96 shocks were delivered during ventricular fibrillation in four large animals. In comparison to the Zoll M series, which delivered a single-vector, biphasic shock, the energy required for successful defibrillation using the unique dual-vector biphasic waveform did not differ significantly (P = 0.65). Conclusions: Our early findings support the feasibility of a unique external defibrillation unit using a dual-vector biphasic waveform approach. This warrants further study to leverage this unique concept and work toward a miniaturized, portable shock delivery system.
AB - Background: Automated external defibrillators can provide life-saving therapies to treat ventricular fibrillation. We developed a prototype unit that can deliver a unique shock waveform produced by four independent capacitors that is delivered through two shock vectors, with the rationale of providing more robust shock pathways during emergent defibrillation. We describe the initial testing and feasibility of this unique defibrillation unit, features of which may enable downsizing of current defibrillator devices. Methods: We tested our defibrillation unit in four large animal models (two canine and two swine) under general anesthesia. Experimental defibrillation thresholds (DFT) were obtained by delivery of a unique waveform shock pulse via a dual-vector pathway with four defibrillation pads (placed across the chest). DFTs were measured and compared with those of a commercially available biphasic defibrillator (Zoll M series, Zoll Medical, Chelmsford, MA, USA) tested in two different vectors. Shocks were delivered after 10 seconds of stable ventricular fibrillation and the output characteristics and shock outcome recorded. Each defibrillation series used a step-down to failure protocol to define the defibrillation threshold. Results: A total of 96 shocks were delivered during ventricular fibrillation in four large animals. In comparison to the Zoll M series, which delivered a single-vector, biphasic shock, the energy required for successful defibrillation using the unique dual-vector biphasic waveform did not differ significantly (P = 0.65). Conclusions: Our early findings support the feasibility of a unique external defibrillation unit using a dual-vector biphasic waveform approach. This warrants further study to leverage this unique concept and work toward a miniaturized, portable shock delivery system.
KW - defibrillator
KW - dual-vector biphasic shock waveform
KW - miniaturized
UR - http://www.scopus.com/inward/record.url?scp=85011632969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011632969&partnerID=8YFLogxK
U2 - 10.1111/pace.12979
DO - 10.1111/pace.12979
M3 - Article
VL - 40
SP - 108
EP - 114
JO - PACE - Pacing and Clinical Electrophysiology
JF - PACE - Pacing and Clinical Electrophysiology
SN - 0147-8389
IS - 2
ER -