Evaluation of a recombinant Listeria monocytogenes expressing an HIV protein that protects mice against viral challenge

Marielena Mata, Zhong Jie Yao, Abba Zubair, Kimberley Syres, Yvonne Paterson

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Vaccine strategies that utilize cell mediated immunity to control infection will be a necessary component of human immunodeficiency virus (HIV) vaccines. In previous studies we have shown that a Listeria monocytogenes recombinant expressing HIV-Gag elicits strong CD8+ and CD4+ T cell responses against HIV Gag in addition to its own secreted proteins. Here, we show that Lm-Gag can protect mice against a viral challenge with a recombinant vaccinia virus expressing Gag, in an antigen specific manner, and that this protection is T cell mediated. These results further support the use of L. monocytogenes as a vaccine approach for HIV through the induction of T cell immunity.

Original languageEnglish (US)
Pages (from-to)1435-1445
Number of pages11
JournalVaccine
Volume19
Issue number11-12
DOIs
StatePublished - Jan 8 2001
Externally publishedYes

Fingerprint

Human Immunodeficiency Virus Proteins
Human immunodeficiency virus
Listeria monocytogenes
HIV
Vaccines
T-lymphocytes
mice
vaccines
T-Lymphocytes
proteins
gag Gene Products
Virus Activation
Vaccinia virus
Infection Control
Cellular Immunity
cell-mediated immunity
Immunity
disease control
immunity
antigens

Keywords

  • HIV
  • Listeria monocytogenes
  • T cells

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Evaluation of a recombinant Listeria monocytogenes expressing an HIV protein that protects mice against viral challenge. / Mata, Marielena; Yao, Zhong Jie; Zubair, Abba; Syres, Kimberley; Paterson, Yvonne.

In: Vaccine, Vol. 19, No. 11-12, 08.01.2001, p. 1435-1445.

Research output: Contribution to journalArticle

Mata, Marielena ; Yao, Zhong Jie ; Zubair, Abba ; Syres, Kimberley ; Paterson, Yvonne. / Evaluation of a recombinant Listeria monocytogenes expressing an HIV protein that protects mice against viral challenge. In: Vaccine. 2001 ; Vol. 19, No. 11-12. pp. 1435-1445.
@article{8433d9a67b2949da9b4eea0da09dfdfe,
title = "Evaluation of a recombinant Listeria monocytogenes expressing an HIV protein that protects mice against viral challenge",
abstract = "Vaccine strategies that utilize cell mediated immunity to control infection will be a necessary component of human immunodeficiency virus (HIV) vaccines. In previous studies we have shown that a Listeria monocytogenes recombinant expressing HIV-Gag elicits strong CD8+ and CD4+ T cell responses against HIV Gag in addition to its own secreted proteins. Here, we show that Lm-Gag can protect mice against a viral challenge with a recombinant vaccinia virus expressing Gag, in an antigen specific manner, and that this protection is T cell mediated. These results further support the use of L. monocytogenes as a vaccine approach for HIV through the induction of T cell immunity.",
keywords = "HIV, Listeria monocytogenes, T cells",
author = "Marielena Mata and Yao, {Zhong Jie} and Abba Zubair and Kimberley Syres and Yvonne Paterson",
year = "2001",
month = "1",
day = "8",
doi = "10.1016/S0264-410X(00)00379-0",
language = "English (US)",
volume = "19",
pages = "1435--1445",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "11-12",

}

TY - JOUR

T1 - Evaluation of a recombinant Listeria monocytogenes expressing an HIV protein that protects mice against viral challenge

AU - Mata, Marielena

AU - Yao, Zhong Jie

AU - Zubair, Abba

AU - Syres, Kimberley

AU - Paterson, Yvonne

PY - 2001/1/8

Y1 - 2001/1/8

N2 - Vaccine strategies that utilize cell mediated immunity to control infection will be a necessary component of human immunodeficiency virus (HIV) vaccines. In previous studies we have shown that a Listeria monocytogenes recombinant expressing HIV-Gag elicits strong CD8+ and CD4+ T cell responses against HIV Gag in addition to its own secreted proteins. Here, we show that Lm-Gag can protect mice against a viral challenge with a recombinant vaccinia virus expressing Gag, in an antigen specific manner, and that this protection is T cell mediated. These results further support the use of L. monocytogenes as a vaccine approach for HIV through the induction of T cell immunity.

AB - Vaccine strategies that utilize cell mediated immunity to control infection will be a necessary component of human immunodeficiency virus (HIV) vaccines. In previous studies we have shown that a Listeria monocytogenes recombinant expressing HIV-Gag elicits strong CD8+ and CD4+ T cell responses against HIV Gag in addition to its own secreted proteins. Here, we show that Lm-Gag can protect mice against a viral challenge with a recombinant vaccinia virus expressing Gag, in an antigen specific manner, and that this protection is T cell mediated. These results further support the use of L. monocytogenes as a vaccine approach for HIV through the induction of T cell immunity.

KW - HIV

KW - Listeria monocytogenes

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=0035825034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035825034&partnerID=8YFLogxK

U2 - 10.1016/S0264-410X(00)00379-0

DO - 10.1016/S0264-410X(00)00379-0

M3 - Article

C2 - 11163666

AN - SCOPUS:0035825034

VL - 19

SP - 1435

EP - 1445

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 11-12

ER -