Evaluation of a recombinant Listeria monocytogenes expressing an HIV protein that protects mice against viral challenge

Marielena Mata, Zhong Jie Yao, Abba Zubair, Kimberley Syres, Yvonne Paterson

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Vaccine strategies that utilize cell mediated immunity to control infection will be a necessary component of human immunodeficiency virus (HIV) vaccines. In previous studies we have shown that a Listeria monocytogenes recombinant expressing HIV-Gag elicits strong CD8+ and CD4+ T cell responses against HIV Gag in addition to its own secreted proteins. Here, we show that Lm-Gag can protect mice against a viral challenge with a recombinant vaccinia virus expressing Gag, in an antigen specific manner, and that this protection is T cell mediated. These results further support the use of L. monocytogenes as a vaccine approach for HIV through the induction of T cell immunity.

Original languageEnglish (US)
Pages (from-to)1435-1445
Number of pages11
JournalVaccine
Volume19
Issue number11-12
DOIs
StatePublished - Jan 8 2001

Keywords

  • HIV
  • Listeria monocytogenes
  • T cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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