Abstract
The aims of this study were to validate stiffness estimates of a phantom undergoing cyclic deformation obtained using a multiphase magnetic resonance elastography (MRE) imaging sequence by comparison with those obtained using a single-phase MRE sequence and to quantify the stability of the multiphase-derived stiffness estimates as a function of deformation frequency and imaging parameters. A spherical rubber shell of 10 cm diameter and 1 cm thickness was connected to a computerized flow pump to produce cyclic pressure variations within the phantom. The phantom was imaged at cyclic pressures between 18-72 bpm using single-phase and multiphase MRE acquisitions. The shear stiffness of the phantom was resolved using a spherical shell wave inversion algorithm. Shear stiffness was averaged over the slice of interest and plotted against pressure within the phantom. A linear correlation was observed between stiffness and pressure. Good correlation (R2 = 0.98) was observed between the stiffness estimates obtained using the standard single-phase and the multiphase pulse sequences. Stiffness estimates obtained using multiphase MRE were stable when the fraction of the deformation period required for acquisition of a single image was not greater than 42%. The results demonstrate the potential of multiphase MRE technique for imaging dynamic organs, such as the heart.
Original language | English (US) |
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Pages (from-to) | 691-698 |
Number of pages | 8 |
Journal | Magnetic Resonance in Medicine |
Volume | 62 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2009 |
Keywords
- Cardiac MRE
- MRE
- Multiphase MRE
- Rapid MRE sequence
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging