Evaluation for clinical predictors of positive temporal artery biopsy in giant cell arteritis

Kevin L. Rieck, Tanaz A. Kermani, Kristine M. Thomsen, William S. Harmsen, Matthew J. Karban, Kenneth J Warrington

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose: To examine the clinical predictors of a positive temporal artery biopsy (TAB) among patients suspected of having giant cell arteritis. Patients and Methods: We conducted a retrospective study of all consecutive patients who underwent TAB by a single surgeon (K.L.R.) at the Department of Oral Maxillofacial Surgery from April 30, 2002, to June 29, 2006. The medical records were reviewed for the clinical symptoms, laboratory findings, biopsy results, and final diagnosis. The variables of interest as predictors of positive biopsy findings were analyzed using logistic regression analysis. Results: During the study period, 82 patients underwent TAB. Histologic evidence of arteritis was present in 22 patients (26.8%). Two (2.4%) were diagnosed with giant cell arteritis clinically but had negative TAB findings. The patients presenting with weight loss or jaw claudication were more likely to have a positive TAB finding (odds ratio 4.50, 95% confidence interval 1.45 to 13.93; and odds ratio 3.71, 95% confidence interval 1.28 to 10.76, respectively). No laboratory findings were predictive of a positive TAB finding. Prednisone use before TAB also was not associated with a decreased likelihood of a positive finding. Conclusions: Patients suspected of having giant cell arteritis were more likely to have a positive TAB finding if they presented with weight loss or jaw claudication. In the present series, corticosteroid therapy before biopsy did not affect the rate of positive TAB findings.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalJournal of Oral and Maxillofacial Surgery
Volume69
Issue number1
DOIs
StatePublished - Jan 2011

Fingerprint

Temporal Arteries
Giant Cell Arteritis
Biopsy
Oral Surgery
Jaw
Weight Loss
Odds Ratio
Confidence Intervals
Arteritis
Prednisone
Medical Records
Adrenal Cortex Hormones

ASJC Scopus subject areas

  • Oral Surgery
  • Otorhinolaryngology
  • Surgery

Cite this

Evaluation for clinical predictors of positive temporal artery biopsy in giant cell arteritis. / Rieck, Kevin L.; Kermani, Tanaz A.; Thomsen, Kristine M.; Harmsen, William S.; Karban, Matthew J.; Warrington, Kenneth J.

In: Journal of Oral and Maxillofacial Surgery, Vol. 69, No. 1, 01.2011, p. 36-40.

Research output: Contribution to journalArticle

Rieck, Kevin L. ; Kermani, Tanaz A. ; Thomsen, Kristine M. ; Harmsen, William S. ; Karban, Matthew J. ; Warrington, Kenneth J. / Evaluation for clinical predictors of positive temporal artery biopsy in giant cell arteritis. In: Journal of Oral and Maxillofacial Surgery. 2011 ; Vol. 69, No. 1. pp. 36-40.
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