Evaluation After Sudden Death in the Young

Belinda Gray, Michael John Ackerman, Christopher Semsarian, Elijah R. Behr

Research output: Contribution to journalArticle

Abstract

Sudden cardiac death is defined as a death occurring usually within an hour of onset of symptoms, arising from an underlying cardiac disease. Sudden cardiac death is a complication of a number of cardiovascular diseases and is often unexpected. In individuals aged <35 years, unexplained sudden cardiac death is the most common presentation. A significant proportion of sudden cardiac death in the young (≤35 years) events may be precipitated by underlying inherited cardiac conditions, including both heritable cardiomyopathies and inherited arrhythmia syndromes (also known as cardiac channelopathies). Tragically, sudden death may be the first manifestation of the disease in a family and, therefore, clinical and genetic evaluation of surviving family members forms a key role in diagnosing the underlying inherited cardiac condition in the family. This is particularly relevant when considering that most inherited cardiac conditions are inherited in an autosomal dominant manner meaning that surviving family members have a 50% chance of inheriting the same disease substrate. This review will outline the underlying causes of sudden cardiac death in the young and outline our universal approach to familial evaluation following a young person's sudden death.

Original languageEnglish (US)
Pages (from-to)e007453
JournalCirculation. Arrhythmia and electrophysiology
Volume12
Issue number8
DOIs
StatePublished - Aug 1 2019

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Sudden Cardiac Death
Sudden Death
Channelopathies
Cardiomyopathies
Cardiac Arrhythmias
Heart Diseases
Cardiovascular Diseases

Keywords

  • cardiomyopathies
  • channelopathies
  • death, sudden, cardiac
  • prevalence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Evaluation After Sudden Death in the Young. / Gray, Belinda; Ackerman, Michael John; Semsarian, Christopher; Behr, Elijah R.

In: Circulation. Arrhythmia and electrophysiology, Vol. 12, No. 8, 01.08.2019, p. e007453.

Research output: Contribution to journalArticle

Gray, Belinda ; Ackerman, Michael John ; Semsarian, Christopher ; Behr, Elijah R. / Evaluation After Sudden Death in the Young. In: Circulation. Arrhythmia and electrophysiology. 2019 ; Vol. 12, No. 8. pp. e007453.
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