EUS-guided ethanol lavage does not reliably ablate pancreatic cystic neoplasms (with video)

Victoria Gómez, Naoki Takahashi, Michael J. Levy, Kiaran Patrick McGee, Andrea Jones, Yajue Huang, Suresh T Chari, Jonathan E. Clain, Ferga C. Gleeson, Randall K. Pearson, Bret Thomas Petersen, Elizabeth Rajan, Santhi Swaroop Vege, Mark Topazian

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30 Scopus citations

Abstract

Background: The true efficacy of EUS-guided ethanol lavage (EEL) of pancreatic cystic neoplasms is unclear. This study aimed to assess long-term outcomes and adverse events of EEL by using a standardized protocol. Methods: Single-center, prospective, pilot study in which participants with suspected mucinous cyst neoplasms or branch duct intraductal papillary mucinous neoplasms ≥1 cm in maximum diameter underwent EEL with 80% ethanol. Follow-up cross-sectional imaging was obtained to assess for changes in cyst volume. Results: Twenty-three patients underwent EEL (57% male, mean age 70 years). Mean duration of follow-up was 40 months (range 9-82 months). Mean calculated final concentration of ethanol achieved in treated cysts was 50% (range 0%-79%). Complete resolution of pancreatic cystic neoplasms occurred in 2 participants (9%). When stratified into those participants who achieved ≥80% versus

Original languageEnglish (US)
JournalGastrointestinal Endoscopy
DOIs
StateAccepted/In press - Jun 16 2015

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ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

Gómez, V., Takahashi, N., Levy, M. J., McGee, K. P., Jones, A., Huang, Y., Chari, S. T., Clain, J. E., Gleeson, F. C., Pearson, R. K., Petersen, B. T., Rajan, E., Vege, S. S., & Topazian, M. (Accepted/In press). EUS-guided ethanol lavage does not reliably ablate pancreatic cystic neoplasms (with video). Gastrointestinal Endoscopy. https://doi.org/10.1016/j.gie.2015.08.069