EUS-guided ethanol lavage does not reliably ablate pancreatic cystic neoplasms (with video)

Victoria Gómez, Naoki Takahashi, Michael J. Levy, Kiaran Patrick McGee, Andrea Jones, Yajue Huang, Suresh T Chari, Jonathan E. Clain, Ferga C. Gleeson, Randall K. Pearson, Bret Thomas Petersen, Elizabeth Rajan, Santhi Swaroop Vege, Mark Topazian

Research output: Contribution to journalArticle

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Abstract

Background: The true efficacy of EUS-guided ethanol lavage (EEL) of pancreatic cystic neoplasms is unclear. This study aimed to assess long-term outcomes and adverse events of EEL by using a standardized protocol. Methods: Single-center, prospective, pilot study in which participants with suspected mucinous cyst neoplasms or branch duct intraductal papillary mucinous neoplasms ≥1 cm in maximum diameter underwent EEL with 80% ethanol. Follow-up cross-sectional imaging was obtained to assess for changes in cyst volume. Results: Twenty-three patients underwent EEL (57% male, mean age 70 years). Mean duration of follow-up was 40 months (range 9-82 months). Mean calculated final concentration of ethanol achieved in treated cysts was 50% (range 0%-79%). Complete resolution of pancreatic cystic neoplasms occurred in 2 participants (9%). When stratified into those participants who achieved ≥80% versus

Original languageEnglish (US)
JournalGastrointestinal Endoscopy
DOIs
StateAccepted/In press - Jun 16 2015

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Therapeutic Irrigation
Pancreatic Neoplasms
Ethanol
Cysts
Neoplasms
Prospective Studies

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

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EUS-guided ethanol lavage does not reliably ablate pancreatic cystic neoplasms (with video). / Gómez, Victoria; Takahashi, Naoki; Levy, Michael J.; McGee, Kiaran Patrick; Jones, Andrea; Huang, Yajue; Chari, Suresh T; Clain, Jonathan E.; Gleeson, Ferga C.; Pearson, Randall K.; Petersen, Bret Thomas; Rajan, Elizabeth; Vege, Santhi Swaroop; Topazian, Mark.

In: Gastrointestinal Endoscopy, 16.06.2015.

Research output: Contribution to journalArticle

Gómez, Victoria ; Takahashi, Naoki ; Levy, Michael J. ; McGee, Kiaran Patrick ; Jones, Andrea ; Huang, Yajue ; Chari, Suresh T ; Clain, Jonathan E. ; Gleeson, Ferga C. ; Pearson, Randall K. ; Petersen, Bret Thomas ; Rajan, Elizabeth ; Vege, Santhi Swaroop ; Topazian, Mark. / EUS-guided ethanol lavage does not reliably ablate pancreatic cystic neoplasms (with video). In: Gastrointestinal Endoscopy. 2015.
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abstract = "Background: The true efficacy of EUS-guided ethanol lavage (EEL) of pancreatic cystic neoplasms is unclear. This study aimed to assess long-term outcomes and adverse events of EEL by using a standardized protocol. Methods: Single-center, prospective, pilot study in which participants with suspected mucinous cyst neoplasms or branch duct intraductal papillary mucinous neoplasms ≥1 cm in maximum diameter underwent EEL with 80{\%} ethanol. Follow-up cross-sectional imaging was obtained to assess for changes in cyst volume. Results: Twenty-three patients underwent EEL (57{\%} male, mean age 70 years). Mean duration of follow-up was 40 months (range 9-82 months). Mean calculated final concentration of ethanol achieved in treated cysts was 50{\%} (range 0{\%}-79{\%}). Complete resolution of pancreatic cystic neoplasms occurred in 2 participants (9{\%}). When stratified into those participants who achieved ≥80{\%} versus",
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AU - Gómez, Victoria

AU - Takahashi, Naoki

AU - Levy, Michael J.

AU - McGee, Kiaran Patrick

AU - Jones, Andrea

AU - Huang, Yajue

AU - Chari, Suresh T

AU - Clain, Jonathan E.

AU - Gleeson, Ferga C.

AU - Pearson, Randall K.

AU - Petersen, Bret Thomas

AU - Rajan, Elizabeth

AU - Vege, Santhi Swaroop

AU - Topazian, Mark

PY - 2015/6/16

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