EURACAN/IASLC Proposals for Updating the Histologic Classification of Pleural Mesothelioma: Towards a More Multidisciplinary Approach

Andrew G. Nicholson, Jennifer L. Sauter, Anna K. Nowak, Hedy L. Kindler, Ritu R. Gill, Martine Remy-Jardin, Samuel G. Armato, Lynnette Fernandez-Cuesta, Raphael Bueno, Nicolas Alcala, Matthieu Foll, Harvey Pass, Richard Attanoos, Paul Baas, Mary Beth Beasley, Luka Brcic, Kelly J. Butnor, Lucian R. Chirieac, Andrew Churg, Pierre CourtiolSanja Dacic, Marc De Perrot, Thomas Frauenfelder, Allen Gibbs, Fred R. Hirsch, Kenzo Hiroshima, Aliya Husain, Sonja Klebe, Sylvie Lantuejoul, Andre Moreira, Isabelle Opitz, Maurice Perol, Anja Roden, Victor Roggli, Arnaud Scherpereel, Frank Tirode, Henry Tazelaar, William D. Travis, Ming Sound Tsao, Paul van Schil, Jean Michel Vignaud, Birgit Weynand, Loic Lang-Lazdunski, Ian Cree, Valerie W. Rusch, Nicolas Girard, Francoise Galateau-Salle

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Introduction: Molecular and immunologic breakthroughs are transforming the management of thoracic cancer, although advances have not been as marked for malignant pleural mesothelioma where pathologic diagnosis has been essentially limited to three histologic subtypes. Methods: A multidisciplinary group (pathologists, molecular biologists, surgeons, radiologists, and oncologists), sponsored by European Network for Rare Adult Solid Cancers/International Association for the Study of Lung Cancer, met in 2018 to critically review the current classification. Results: Recommendations include: (1) classification should be updated to include architectural patterns and stromal and cytologic features that refine prognostication; (2) subject to data accrual, malignant mesothelioma in situ could be an additional category; (3) grading of epithelioid malignant pleural mesotheliomas should be routinely undertaken; (4) favorable/unfavorable histologic characteristics should be routinely reported; (5) clinically relevant molecular data (programmed death ligand 1, BRCA 1 associated protein 1 [BAP1], and cyclin dependent kinase inhibitor 2A) should be incorporated into reports, if undertaken; (6) other molecular data should be accrued as part of future trials; (7) resection specimens (i.e., extended pleurectomy/decortication and extrapleural pneumonectomy) should be pathologically staged with smaller specimens being clinically staged; (8) ideally, at least three separate areas should be sampled from the pleural cavity, including areas of interest identified on pre-surgical imaging; (9) image-acquisition protocols/imaging terminology should be standardized to aid research/refine clinical staging; (10) multidisciplinary tumor boards should include pathologists to ensure appropriate treatment options are considered; (11) all histologic subtypes should be considered potential candidates for chemotherapy; (12) patients with sarcomatoid or biphasic mesothelioma should not be excluded from first-line clinical trials unless there is a compelling reason; (13) tumor subtyping should be further assessed in relation to duration of response to immunotherapy; and (14) systematic screening of all patients for germline mutations is not recommended, in the absence of a family history suspicious for BAP1 syndrome. Conclusions: These multidisciplinary recommendations for pathology classification and application will allow more informative pathologic reporting and potential risk stratification, to support clinical practice, research investigation and clinical trials.

Original languageEnglish (US)
Pages (from-to)29-49
Number of pages21
JournalJournal of Thoracic Oncology
Volume15
Issue number1
DOIs
StatePublished - Jan 2020

Keywords

  • Classification
  • Mesothelioma
  • Multidisciplinary
  • Pathology

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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    Nicholson, A. G., Sauter, J. L., Nowak, A. K., Kindler, H. L., Gill, R. R., Remy-Jardin, M., Armato, S. G., Fernandez-Cuesta, L., Bueno, R., Alcala, N., Foll, M., Pass, H., Attanoos, R., Baas, P., Beasley, M. B., Brcic, L., Butnor, K. J., Chirieac, L. R., Churg, A., ... Galateau-Salle, F. (2020). EURACAN/IASLC Proposals for Updating the Histologic Classification of Pleural Mesothelioma: Towards a More Multidisciplinary Approach. Journal of Thoracic Oncology, 15(1), 29-49. https://doi.org/10.1016/j.jtho.2019.08.2506