Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation

Mustapha Abubakar, Jenny Chang-Claude, H. Raza Ali, Nilanjan Chatterjee, Penny Coulson, Frances Daley, Fiona Blows, Javier Benitez, Roger L. Milne, Hermann Brenner, Christa Stegmaier, Arto Mannermaa, Anja Rudolph, Peter Sinn, Fergus J Couch, Peter Devilee, Rob A.E.M. Tollenaar, Caroline Seynaeve, Jonine Figueroa, Jolanta LissowskaStephen Hewitt, Maartje J. Hooning, Antoinette Hollestelle, Renée Foekens, Linetta B. Koppert, Manjeet K. Bolla, Qin Wang, Michael E. Jones, Minouk J. Schoemaker, Renske Keeman, Douglas F. Easton, Anthony J. Swerdlow, Mark E. Sherman, Mark E. Sherman, Paul D. Pharoah, Montserrat Garcia-Closas

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ breast cancer cases and 26,281 controls from 11 epidemiological studies. Proliferation was determined by centralized automated measures of KI67 in tissue microarrays. Odds ratios (OR), 95% confidence intervals (CI) and p-values for case-case and case-control comparisons for risk factors in relation to levels of grade and quartiles (Q1-Q4) of KI67 were estimated using polytomous logistic regression models. Case-case comparisons showed associations between nulliparity and high KI67 [OR (95% CI) for Q4 vs. Q1=1.54 (1.22, 1.95)]; obesity and high grade [grade 3 vs. 1=1.68 (1.31, 2.16)] and current use of combined hormone therapy (HT) and low grade [grade 3 vs. 1=0.27 (0.16, 0.44)] tumors. In case-control comparisons, nulliparity was associated with elevated risk of tumors with high but not low levels of proliferation [1.43 (1.14, 1.81) for KI67 Q4 vs. 0.83 (0.60, 1.14) for KI67 Q1]; obesity among women ≥50 years with high but not low grade tumors [1.55 (1.17, 2.06) for grade 3 vs. 0.88 (0.66, 1.16) for grade 1] and HT with low but not high grade tumors [3.07 (2.22, 4.23) for grade 1 vs. 0.85 (0.55, 1.30) for grade 3]. Menarcheal age and family history were similarly associated with HR+ tumors of different grade or KI67 levels. These findings provide insights into the etiologic heterogeneity of HR+ tumors.

Original languageEnglish (US)
JournalInternational Journal of Cancer
DOIs
StateAccepted/In press - Jan 1 2018

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Hormones
Breast Neoplasms
Neoplasms
Parity
Obesity
Logistic Models
Odds Ratio
Confidence Intervals
Epidemiologic Studies
Pathology
Therapeutics

Keywords

  • Breast cancer
  • Epidemiology
  • Grade
  • Hormone therapy
  • KI67
  • Nulliparity
  • Obesity
  • Proliferation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Abubakar, M., Chang-Claude, J., Ali, H. R., Chatterjee, N., Coulson, P., Daley, F., ... Garcia-Closas, M. (Accepted/In press). Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. International Journal of Cancer. https://doi.org/10.1002/ijc.31352

Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. / Abubakar, Mustapha; Chang-Claude, Jenny; Ali, H. Raza; Chatterjee, Nilanjan; Coulson, Penny; Daley, Frances; Blows, Fiona; Benitez, Javier; Milne, Roger L.; Brenner, Hermann; Stegmaier, Christa; Mannermaa, Arto; Rudolph, Anja; Sinn, Peter; Couch, Fergus J; Devilee, Peter; Tollenaar, Rob A.E.M.; Seynaeve, Caroline; Figueroa, Jonine; Lissowska, Jolanta; Hewitt, Stephen; Hooning, Maartje J.; Hollestelle, Antoinette; Foekens, Renée; Koppert, Linetta B.; Bolla, Manjeet K.; Wang, Qin; Jones, Michael E.; Schoemaker, Minouk J.; Keeman, Renske; Easton, Douglas F.; Swerdlow, Anthony J.; Sherman, Mark E.; Sherman, Mark E.; Pharoah, Paul D.; Garcia-Closas, Montserrat.

In: International Journal of Cancer, 01.01.2018.

Research output: Contribution to journalArticle

Abubakar, M, Chang-Claude, J, Ali, HR, Chatterjee, N, Coulson, P, Daley, F, Blows, F, Benitez, J, Milne, RL, Brenner, H, Stegmaier, C, Mannermaa, A, Rudolph, A, Sinn, P, Couch, FJ, Devilee, P, Tollenaar, RAEM, Seynaeve, C, Figueroa, J, Lissowska, J, Hewitt, S, Hooning, MJ, Hollestelle, A, Foekens, R, Koppert, LB, Bolla, MK, Wang, Q, Jones, ME, Schoemaker, MJ, Keeman, R, Easton, DF, Swerdlow, AJ, Sherman, ME, Sherman, ME, Pharoah, PD & Garcia-Closas, M 2018, 'Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation', International Journal of Cancer. https://doi.org/10.1002/ijc.31352
Abubakar, Mustapha ; Chang-Claude, Jenny ; Ali, H. Raza ; Chatterjee, Nilanjan ; Coulson, Penny ; Daley, Frances ; Blows, Fiona ; Benitez, Javier ; Milne, Roger L. ; Brenner, Hermann ; Stegmaier, Christa ; Mannermaa, Arto ; Rudolph, Anja ; Sinn, Peter ; Couch, Fergus J ; Devilee, Peter ; Tollenaar, Rob A.E.M. ; Seynaeve, Caroline ; Figueroa, Jonine ; Lissowska, Jolanta ; Hewitt, Stephen ; Hooning, Maartje J. ; Hollestelle, Antoinette ; Foekens, Renée ; Koppert, Linetta B. ; Bolla, Manjeet K. ; Wang, Qin ; Jones, Michael E. ; Schoemaker, Minouk J. ; Keeman, Renske ; Easton, Douglas F. ; Swerdlow, Anthony J. ; Sherman, Mark E. ; Sherman, Mark E. ; Pharoah, Paul D. ; Garcia-Closas, Montserrat. / Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. In: International Journal of Cancer. 2018.
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abstract = "Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ breast cancer cases and 26,281 controls from 11 epidemiological studies. Proliferation was determined by centralized automated measures of KI67 in tissue microarrays. Odds ratios (OR), 95{\%} confidence intervals (CI) and p-values for case-case and case-control comparisons for risk factors in relation to levels of grade and quartiles (Q1-Q4) of KI67 were estimated using polytomous logistic regression models. Case-case comparisons showed associations between nulliparity and high KI67 [OR (95{\%} CI) for Q4 vs. Q1=1.54 (1.22, 1.95)]; obesity and high grade [grade 3 vs. 1=1.68 (1.31, 2.16)] and current use of combined hormone therapy (HT) and low grade [grade 3 vs. 1=0.27 (0.16, 0.44)] tumors. In case-control comparisons, nulliparity was associated with elevated risk of tumors with high but not low levels of proliferation [1.43 (1.14, 1.81) for KI67 Q4 vs. 0.83 (0.60, 1.14) for KI67 Q1]; obesity among women ≥50 years with high but not low grade tumors [1.55 (1.17, 2.06) for grade 3 vs. 0.88 (0.66, 1.16) for grade 1] and HT with low but not high grade tumors [3.07 (2.22, 4.23) for grade 1 vs. 0.85 (0.55, 1.30) for grade 3]. Menarcheal age and family history were similarly associated with HR+ tumors of different grade or KI67 levels. These findings provide insights into the etiologic heterogeneity of HR+ tumors.",
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AU - Abubakar, Mustapha

AU - Chang-Claude, Jenny

AU - Ali, H. Raza

AU - Chatterjee, Nilanjan

AU - Coulson, Penny

AU - Daley, Frances

AU - Blows, Fiona

AU - Benitez, Javier

AU - Milne, Roger L.

AU - Brenner, Hermann

AU - Stegmaier, Christa

AU - Mannermaa, Arto

AU - Rudolph, Anja

AU - Sinn, Peter

AU - Couch, Fergus J

AU - Devilee, Peter

AU - Tollenaar, Rob A.E.M.

AU - Seynaeve, Caroline

AU - Figueroa, Jonine

AU - Lissowska, Jolanta

AU - Hewitt, Stephen

AU - Hooning, Maartje J.

AU - Hollestelle, Antoinette

AU - Foekens, Renée

AU - Koppert, Linetta B.

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Jones, Michael E.

AU - Schoemaker, Minouk J.

AU - Keeman, Renske

AU - Easton, Douglas F.

AU - Swerdlow, Anthony J.

AU - Sherman, Mark E.

AU - Sherman, Mark E.

AU - Pharoah, Paul D.

AU - Garcia-Closas, Montserrat

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N2 - Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ breast cancer cases and 26,281 controls from 11 epidemiological studies. Proliferation was determined by centralized automated measures of KI67 in tissue microarrays. Odds ratios (OR), 95% confidence intervals (CI) and p-values for case-case and case-control comparisons for risk factors in relation to levels of grade and quartiles (Q1-Q4) of KI67 were estimated using polytomous logistic regression models. Case-case comparisons showed associations between nulliparity and high KI67 [OR (95% CI) for Q4 vs. Q1=1.54 (1.22, 1.95)]; obesity and high grade [grade 3 vs. 1=1.68 (1.31, 2.16)] and current use of combined hormone therapy (HT) and low grade [grade 3 vs. 1=0.27 (0.16, 0.44)] tumors. In case-control comparisons, nulliparity was associated with elevated risk of tumors with high but not low levels of proliferation [1.43 (1.14, 1.81) for KI67 Q4 vs. 0.83 (0.60, 1.14) for KI67 Q1]; obesity among women ≥50 years with high but not low grade tumors [1.55 (1.17, 2.06) for grade 3 vs. 0.88 (0.66, 1.16) for grade 1] and HT with low but not high grade tumors [3.07 (2.22, 4.23) for grade 1 vs. 0.85 (0.55, 1.30) for grade 3]. Menarcheal age and family history were similarly associated with HR+ tumors of different grade or KI67 levels. These findings provide insights into the etiologic heterogeneity of HR+ tumors.

AB - Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ breast cancer cases and 26,281 controls from 11 epidemiological studies. Proliferation was determined by centralized automated measures of KI67 in tissue microarrays. Odds ratios (OR), 95% confidence intervals (CI) and p-values for case-case and case-control comparisons for risk factors in relation to levels of grade and quartiles (Q1-Q4) of KI67 were estimated using polytomous logistic regression models. Case-case comparisons showed associations between nulliparity and high KI67 [OR (95% CI) for Q4 vs. Q1=1.54 (1.22, 1.95)]; obesity and high grade [grade 3 vs. 1=1.68 (1.31, 2.16)] and current use of combined hormone therapy (HT) and low grade [grade 3 vs. 1=0.27 (0.16, 0.44)] tumors. In case-control comparisons, nulliparity was associated with elevated risk of tumors with high but not low levels of proliferation [1.43 (1.14, 1.81) for KI67 Q4 vs. 0.83 (0.60, 1.14) for KI67 Q1]; obesity among women ≥50 years with high but not low grade tumors [1.55 (1.17, 2.06) for grade 3 vs. 0.88 (0.66, 1.16) for grade 1] and HT with low but not high grade tumors [3.07 (2.22, 4.23) for grade 1 vs. 0.85 (0.55, 1.30) for grade 3]. Menarcheal age and family history were similarly associated with HR+ tumors of different grade or KI67 levels. These findings provide insights into the etiologic heterogeneity of HR+ tumors.

KW - Breast cancer

KW - Epidemiology

KW - Grade

KW - Hormone therapy

KW - KI67

KW - Nulliparity

KW - Obesity

KW - Proliferation

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