Etiology-based diagnostic approach to proliferative glomerulonephritis

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Proliferative glomerulonephritis (GN) often is classified based on the pattern of injury. The pattern of injury does not reveal the underlying cause. New insights into the causes of proliferative GN suggest that determining the type of deposits is more likely to provide clues to the underlying cause than determining the pattern of injury. This article proposes a new classification of proliferative GN that links findings from both immunofluorescence and light microscopy. The basis of the classification is whether the proliferative GN is immune complex mediated, pauci-immune, or complement mediated; the type of immunoglobulin deposits and complement factors then determine or suggest the underlying cause. One of the aims of the proposed classification system is to focus on the pathophysiology of the GN with emphasis on the underlying cause, leading to appropriate evaluation and management. The second aim is to simplify and standardize the classification of proliferative GN.

Original languageEnglish (US)
Pages (from-to)561-566
Number of pages6
JournalAmerican Journal of Kidney Diseases
Volume63
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Glomerulonephritis
Wounds and Injuries
Antigen-Antibody Complex
Fluorescence Microscopy
Immunoglobulins
Light

Keywords

  • C3 glomerulonephritis
  • classification
  • complement
  • Glomerulonephritis
  • membranoproliferative glomerulonephritis

ASJC Scopus subject areas

  • Nephrology

Cite this

Etiology-based diagnostic approach to proliferative glomerulonephritis. / Sethi, Sanjeev M.

In: American Journal of Kidney Diseases, Vol. 63, No. 4, 2014, p. 561-566.

Research output: Contribution to journalArticle

@article{4123222a35084f9caf47218d9560dbed,
title = "Etiology-based diagnostic approach to proliferative glomerulonephritis",
abstract = "Proliferative glomerulonephritis (GN) often is classified based on the pattern of injury. The pattern of injury does not reveal the underlying cause. New insights into the causes of proliferative GN suggest that determining the type of deposits is more likely to provide clues to the underlying cause than determining the pattern of injury. This article proposes a new classification of proliferative GN that links findings from both immunofluorescence and light microscopy. The basis of the classification is whether the proliferative GN is immune complex mediated, pauci-immune, or complement mediated; the type of immunoglobulin deposits and complement factors then determine or suggest the underlying cause. One of the aims of the proposed classification system is to focus on the pathophysiology of the GN with emphasis on the underlying cause, leading to appropriate evaluation and management. The second aim is to simplify and standardize the classification of proliferative GN.",
keywords = "C3 glomerulonephritis, classification, complement, Glomerulonephritis, membranoproliferative glomerulonephritis",
author = "Sethi, {Sanjeev M}",
year = "2014",
doi = "10.1053/j.ajkd.2013.11.019",
language = "English (US)",
volume = "63",
pages = "561--566",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Etiology-based diagnostic approach to proliferative glomerulonephritis

AU - Sethi, Sanjeev M

PY - 2014

Y1 - 2014

N2 - Proliferative glomerulonephritis (GN) often is classified based on the pattern of injury. The pattern of injury does not reveal the underlying cause. New insights into the causes of proliferative GN suggest that determining the type of deposits is more likely to provide clues to the underlying cause than determining the pattern of injury. This article proposes a new classification of proliferative GN that links findings from both immunofluorescence and light microscopy. The basis of the classification is whether the proliferative GN is immune complex mediated, pauci-immune, or complement mediated; the type of immunoglobulin deposits and complement factors then determine or suggest the underlying cause. One of the aims of the proposed classification system is to focus on the pathophysiology of the GN with emphasis on the underlying cause, leading to appropriate evaluation and management. The second aim is to simplify and standardize the classification of proliferative GN.

AB - Proliferative glomerulonephritis (GN) often is classified based on the pattern of injury. The pattern of injury does not reveal the underlying cause. New insights into the causes of proliferative GN suggest that determining the type of deposits is more likely to provide clues to the underlying cause than determining the pattern of injury. This article proposes a new classification of proliferative GN that links findings from both immunofluorescence and light microscopy. The basis of the classification is whether the proliferative GN is immune complex mediated, pauci-immune, or complement mediated; the type of immunoglobulin deposits and complement factors then determine or suggest the underlying cause. One of the aims of the proposed classification system is to focus on the pathophysiology of the GN with emphasis on the underlying cause, leading to appropriate evaluation and management. The second aim is to simplify and standardize the classification of proliferative GN.

KW - C3 glomerulonephritis

KW - classification

KW - complement

KW - Glomerulonephritis

KW - membranoproliferative glomerulonephritis

UR - http://www.scopus.com/inward/record.url?scp=84897116007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897116007&partnerID=8YFLogxK

U2 - 10.1053/j.ajkd.2013.11.019

DO - 10.1053/j.ajkd.2013.11.019

M3 - Article

C2 - 24387793

AN - SCOPUS:84897116007

VL - 63

SP - 561

EP - 566

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 4

ER -