Etiologic heterogeneity among non-Hodgkin lymphoma subtypes

Lindsay M. Morton, Sophia S. Wang, Wendy Cozen, Martha S. Linet, Nilanjan Chatterjee, Scott Davis, Richard K. Severson, Joanne S. Colt, Mohammad A. Vasef, Nathaniel Rothman, Aaron Blair, Leslie Bernstein, Amanda J. Cross, Anneclaire J. De Roos, Eric A. Engels, David W. Hein, Deirdre A. Hill, Linda E. Kelemen, Unhee Lim, Charles F. LynchMaryjean Schenk, Sholom Wacholder, Mary H. Ward, Shelia Hoar Zahm, Stephen J. Chanock, James R Cerhan, Patricia Hartge

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Understanding patterns of etiologic commonality and heterogeneity for non-Hodgkin lymphomas may illuminate lymphomagenesis. We present the first systematic comparison of risks by lymphoma subtype for a broad range of putative risk factors in a population-based case-control study, including diffuse large B-cell (DLBCL; N = 416), follicular (N = 318), and marginal zone lymphomas (N = 106), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/ SLL; N = 133). We required at least 2 of 3 analyses to support differences in risk: (1) polytomous logistic regression, (2) homogeneity tests, or (3) dichotomous logistic regression, analyzing all 7 possible pairwise comparisons among the subtypes, corresponding to various groupings by clinical behavior, genetic features, and differentiation. Late birth order and high body mass index (≥ 35) kg/m 2) increased risk for DLBCL alone. Autoimmune conditions increased risk for marginal zone lymphoma alone. The tumor necrosis factor G-308A polymorphism (rs1800629) increased risks for both DLBCL and marginal zone lymphoma. Exposure to certain dietary heterocyclic amines from meat consumption increased risk for CLL/SLL alone. We observed no significant risk factors for follicular lymphoma alone. These data clearly support both etiologic commonality and heterogeneity for lymphoma subtypes, suggesting that immune dysfunction is of greater etiologic importance for DLBCL and marginal zone lymphoma than for CLL/SLL and follicular lymphoma.

Original languageEnglish (US)
Pages (from-to)5150-5160
Number of pages11
JournalBlood
Volume112
Issue number13
DOIs
StatePublished - Dec 15 2008

Fingerprint

Non-Hodgkin's Lymphoma
Lymphoma
Follicular Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Logistic Models
Logistics
Birth Order
Meat
Amines
Case-Control Studies
Meats
Body Mass Index
B-Lymphocytes
Tumor Necrosis Factor-alpha
Polymorphism
Cells
Population

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Morton, L. M., Wang, S. S., Cozen, W., Linet, M. S., Chatterjee, N., Davis, S., ... Hartge, P. (2008). Etiologic heterogeneity among non-Hodgkin lymphoma subtypes. Blood, 112(13), 5150-5160. https://doi.org/10.1182/blood-2008-01-133587

Etiologic heterogeneity among non-Hodgkin lymphoma subtypes. / Morton, Lindsay M.; Wang, Sophia S.; Cozen, Wendy; Linet, Martha S.; Chatterjee, Nilanjan; Davis, Scott; Severson, Richard K.; Colt, Joanne S.; Vasef, Mohammad A.; Rothman, Nathaniel; Blair, Aaron; Bernstein, Leslie; Cross, Amanda J.; De Roos, Anneclaire J.; Engels, Eric A.; Hein, David W.; Hill, Deirdre A.; Kelemen, Linda E.; Lim, Unhee; Lynch, Charles F.; Schenk, Maryjean; Wacholder, Sholom; Ward, Mary H.; Zahm, Shelia Hoar; Chanock, Stephen J.; Cerhan, James R; Hartge, Patricia.

In: Blood, Vol. 112, No. 13, 15.12.2008, p. 5150-5160.

Research output: Contribution to journalArticle

Morton, LM, Wang, SS, Cozen, W, Linet, MS, Chatterjee, N, Davis, S, Severson, RK, Colt, JS, Vasef, MA, Rothman, N, Blair, A, Bernstein, L, Cross, AJ, De Roos, AJ, Engels, EA, Hein, DW, Hill, DA, Kelemen, LE, Lim, U, Lynch, CF, Schenk, M, Wacholder, S, Ward, MH, Zahm, SH, Chanock, SJ, Cerhan, JR & Hartge, P 2008, 'Etiologic heterogeneity among non-Hodgkin lymphoma subtypes', Blood, vol. 112, no. 13, pp. 5150-5160. https://doi.org/10.1182/blood-2008-01-133587
Morton LM, Wang SS, Cozen W, Linet MS, Chatterjee N, Davis S et al. Etiologic heterogeneity among non-Hodgkin lymphoma subtypes. Blood. 2008 Dec 15;112(13):5150-5160. https://doi.org/10.1182/blood-2008-01-133587
Morton, Lindsay M. ; Wang, Sophia S. ; Cozen, Wendy ; Linet, Martha S. ; Chatterjee, Nilanjan ; Davis, Scott ; Severson, Richard K. ; Colt, Joanne S. ; Vasef, Mohammad A. ; Rothman, Nathaniel ; Blair, Aaron ; Bernstein, Leslie ; Cross, Amanda J. ; De Roos, Anneclaire J. ; Engels, Eric A. ; Hein, David W. ; Hill, Deirdre A. ; Kelemen, Linda E. ; Lim, Unhee ; Lynch, Charles F. ; Schenk, Maryjean ; Wacholder, Sholom ; Ward, Mary H. ; Zahm, Shelia Hoar ; Chanock, Stephen J. ; Cerhan, James R ; Hartge, Patricia. / Etiologic heterogeneity among non-Hodgkin lymphoma subtypes. In: Blood. 2008 ; Vol. 112, No. 13. pp. 5150-5160.
@article{62a24f56d2bc4172a0353f9fcfd78f40,
title = "Etiologic heterogeneity among non-Hodgkin lymphoma subtypes",
abstract = "Understanding patterns of etiologic commonality and heterogeneity for non-Hodgkin lymphomas may illuminate lymphomagenesis. We present the first systematic comparison of risks by lymphoma subtype for a broad range of putative risk factors in a population-based case-control study, including diffuse large B-cell (DLBCL; N = 416), follicular (N = 318), and marginal zone lymphomas (N = 106), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/ SLL; N = 133). We required at least 2 of 3 analyses to support differences in risk: (1) polytomous logistic regression, (2) homogeneity tests, or (3) dichotomous logistic regression, analyzing all 7 possible pairwise comparisons among the subtypes, corresponding to various groupings by clinical behavior, genetic features, and differentiation. Late birth order and high body mass index (≥ 35) kg/m 2) increased risk for DLBCL alone. Autoimmune conditions increased risk for marginal zone lymphoma alone. The tumor necrosis factor G-308A polymorphism (rs1800629) increased risks for both DLBCL and marginal zone lymphoma. Exposure to certain dietary heterocyclic amines from meat consumption increased risk for CLL/SLL alone. We observed no significant risk factors for follicular lymphoma alone. These data clearly support both etiologic commonality and heterogeneity for lymphoma subtypes, suggesting that immune dysfunction is of greater etiologic importance for DLBCL and marginal zone lymphoma than for CLL/SLL and follicular lymphoma.",
author = "Morton, {Lindsay M.} and Wang, {Sophia S.} and Wendy Cozen and Linet, {Martha S.} and Nilanjan Chatterjee and Scott Davis and Severson, {Richard K.} and Colt, {Joanne S.} and Vasef, {Mohammad A.} and Nathaniel Rothman and Aaron Blair and Leslie Bernstein and Cross, {Amanda J.} and {De Roos}, {Anneclaire J.} and Engels, {Eric A.} and Hein, {David W.} and Hill, {Deirdre A.} and Kelemen, {Linda E.} and Unhee Lim and Lynch, {Charles F.} and Maryjean Schenk and Sholom Wacholder and Ward, {Mary H.} and Zahm, {Shelia Hoar} and Chanock, {Stephen J.} and Cerhan, {James R} and Patricia Hartge",
year = "2008",
month = "12",
day = "15",
doi = "10.1182/blood-2008-01-133587",
language = "English (US)",
volume = "112",
pages = "5150--5160",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "13",

}

TY - JOUR

T1 - Etiologic heterogeneity among non-Hodgkin lymphoma subtypes

AU - Morton, Lindsay M.

AU - Wang, Sophia S.

AU - Cozen, Wendy

AU - Linet, Martha S.

AU - Chatterjee, Nilanjan

AU - Davis, Scott

AU - Severson, Richard K.

AU - Colt, Joanne S.

AU - Vasef, Mohammad A.

AU - Rothman, Nathaniel

AU - Blair, Aaron

AU - Bernstein, Leslie

AU - Cross, Amanda J.

AU - De Roos, Anneclaire J.

AU - Engels, Eric A.

AU - Hein, David W.

AU - Hill, Deirdre A.

AU - Kelemen, Linda E.

AU - Lim, Unhee

AU - Lynch, Charles F.

AU - Schenk, Maryjean

AU - Wacholder, Sholom

AU - Ward, Mary H.

AU - Zahm, Shelia Hoar

AU - Chanock, Stephen J.

AU - Cerhan, James R

AU - Hartge, Patricia

PY - 2008/12/15

Y1 - 2008/12/15

N2 - Understanding patterns of etiologic commonality and heterogeneity for non-Hodgkin lymphomas may illuminate lymphomagenesis. We present the first systematic comparison of risks by lymphoma subtype for a broad range of putative risk factors in a population-based case-control study, including diffuse large B-cell (DLBCL; N = 416), follicular (N = 318), and marginal zone lymphomas (N = 106), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/ SLL; N = 133). We required at least 2 of 3 analyses to support differences in risk: (1) polytomous logistic regression, (2) homogeneity tests, or (3) dichotomous logistic regression, analyzing all 7 possible pairwise comparisons among the subtypes, corresponding to various groupings by clinical behavior, genetic features, and differentiation. Late birth order and high body mass index (≥ 35) kg/m 2) increased risk for DLBCL alone. Autoimmune conditions increased risk for marginal zone lymphoma alone. The tumor necrosis factor G-308A polymorphism (rs1800629) increased risks for both DLBCL and marginal zone lymphoma. Exposure to certain dietary heterocyclic amines from meat consumption increased risk for CLL/SLL alone. We observed no significant risk factors for follicular lymphoma alone. These data clearly support both etiologic commonality and heterogeneity for lymphoma subtypes, suggesting that immune dysfunction is of greater etiologic importance for DLBCL and marginal zone lymphoma than for CLL/SLL and follicular lymphoma.

AB - Understanding patterns of etiologic commonality and heterogeneity for non-Hodgkin lymphomas may illuminate lymphomagenesis. We present the first systematic comparison of risks by lymphoma subtype for a broad range of putative risk factors in a population-based case-control study, including diffuse large B-cell (DLBCL; N = 416), follicular (N = 318), and marginal zone lymphomas (N = 106), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/ SLL; N = 133). We required at least 2 of 3 analyses to support differences in risk: (1) polytomous logistic regression, (2) homogeneity tests, or (3) dichotomous logistic regression, analyzing all 7 possible pairwise comparisons among the subtypes, corresponding to various groupings by clinical behavior, genetic features, and differentiation. Late birth order and high body mass index (≥ 35) kg/m 2) increased risk for DLBCL alone. Autoimmune conditions increased risk for marginal zone lymphoma alone. The tumor necrosis factor G-308A polymorphism (rs1800629) increased risks for both DLBCL and marginal zone lymphoma. Exposure to certain dietary heterocyclic amines from meat consumption increased risk for CLL/SLL alone. We observed no significant risk factors for follicular lymphoma alone. These data clearly support both etiologic commonality and heterogeneity for lymphoma subtypes, suggesting that immune dysfunction is of greater etiologic importance for DLBCL and marginal zone lymphoma than for CLL/SLL and follicular lymphoma.

UR - http://www.scopus.com/inward/record.url?scp=58149384454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149384454&partnerID=8YFLogxK

U2 - 10.1182/blood-2008-01-133587

DO - 10.1182/blood-2008-01-133587

M3 - Article

C2 - 18796628

AN - SCOPUS:58149384454

VL - 112

SP - 5150

EP - 5160

JO - Blood

JF - Blood

SN - 0006-4971

IS - 13

ER -