TY - JOUR
T1 - Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME)cohort
AU - Santos, Octavio A.
AU - Pedraza, Otto
AU - Lucas, John A.
AU - Duara, Ranjan
AU - Greig-Custo, Maria T.
AU - Hanna Al-Shaikh, Fadi S.
AU - Liesinger, Amanda M.
AU - Bieniek, Kevin F.
AU - Hinkle, Kelly M.
AU - Lesser, Elizabeth R.
AU - Crook, Julia E.
AU - Carrasquillo, Minerva M.
AU - Ross, Owen A.
AU - Ertekin-Taner, Nilüfer
AU - Graff-Radford, Neill R.
AU - Dickson, Dennis W.
AU - Murray, Melissa E.
N1 - Funding Information:
This study was supported by the Florida Department of Health , Ed and Ethel Moore Alzheimer's Disease Research Program (Murray; 6AZ01 and 8AZ06) and the National Institute on Aging (NIA) of the National Institutes of Health (NIH) (under Award Number R01-AG054449 [Murray], P50-AG016574 [Graff-Radford], and P50-AG047266 [Ertekin-Taner]). This work was in part supported by the Alzheimer's Association 2018-AARFD-592421 (Santos), Florida Department of Health , Ed and Ethel Moore Alzheimer's Disease Research Program grants 7AZ17 (Ertekin-Taner), 7AZ07 (Carrasquillo), and NIH / NIA R03-AG055677 (Carrasquillo). Additional funding for brain banking came from the State of Florida, Department of Elder Affairs, Alzheimer's Disease Initiative.
Funding Information:
The authors thank the patients and their families for their generous brain donations to help further our knowledge of ethnoracial differences in AD and related dementias. The authors would like to acknowledge the endless hours of commitment and teamwork offered by Virginia Phillips, Monica Castanedes-Casey, and Jessica F. Tranovich. This study was supported by the Florida Department of Health, Ed and Ethel Moore Alzheimer's Disease Research Program (Murray; 6AZ01 and 8AZ06)and the National Institute on Aging (NIA)of the National Institutes of Health (NIH)(under Award Number R01-AG054449 [Murray], P50-AG016574 [Graff-Radford], and P50-AG047266 [Ertekin-Taner]). This work was in part supported by the Alzheimer's Association 2018-AARFD-592421 (Santos), Florida Department of Health, Ed and Ethel Moore Alzheimer's Disease Research Program grants 7AZ17 (Ertekin-Taner), 7AZ07 (Carrasquillo), and NIH/NIA R03-AG055677 (Carrasquillo). Additional funding for brain banking came from the State of Florida, Department of Elder Affairs, Alzheimer's Disease Initiative.
Publisher Copyright:
© 2019 The Authors
PY - 2019/5
Y1 - 2019/5
N2 - Introduction: Our primary goal was to examine demographic and clinicopathologic differences across an ethnoracially diverse autopsy-confirmed cohort of Alzheimer's disease cases. Methods: A retrospective study was conducted in the Florida Autopsied Multi-Ethnic cohort on 1625 Alzheimer's disease cases, including decedents who self-reported as Hispanic/Latino (n = 67), black/African American (n = 19), and white/European American (n = 1539). Results: Hispanic decedents had a higher frequency of family history of cognitive impairment (58%), an earlier age at onset (median age of 70 years), longer disease duration (median of 12 years), and lower MMSE proximal to death (median of 4 points)compared with the other ethnoracial groups. Black decedents had a lower Braak tangle stage (stage V)and higher frequency of coexisting hippocampal sclerosis (21%); however, only hippocampal sclerosis differences survived adjustment for sex, age at onset, and disease duration. Neither Thal amyloid phase nor coexisting Lewy body disease differed across ethnoracial groups. Discussion: Despite a smaller sample size, Hispanics demonstrated longer disease duration with Alzheimer's disease, but not greater lifespan. Neuropathologic differences across ethnoracial groups supported differences in tau pathology distribution and coexisting hippocampal sclerosis, which may impact biomarker studies.
AB - Introduction: Our primary goal was to examine demographic and clinicopathologic differences across an ethnoracially diverse autopsy-confirmed cohort of Alzheimer's disease cases. Methods: A retrospective study was conducted in the Florida Autopsied Multi-Ethnic cohort on 1625 Alzheimer's disease cases, including decedents who self-reported as Hispanic/Latino (n = 67), black/African American (n = 19), and white/European American (n = 1539). Results: Hispanic decedents had a higher frequency of family history of cognitive impairment (58%), an earlier age at onset (median age of 70 years), longer disease duration (median of 12 years), and lower MMSE proximal to death (median of 4 points)compared with the other ethnoracial groups. Black decedents had a lower Braak tangle stage (stage V)and higher frequency of coexisting hippocampal sclerosis (21%); however, only hippocampal sclerosis differences survived adjustment for sex, age at onset, and disease duration. Neither Thal amyloid phase nor coexisting Lewy body disease differed across ethnoracial groups. Discussion: Despite a smaller sample size, Hispanics demonstrated longer disease duration with Alzheimer's disease, but not greater lifespan. Neuropathologic differences across ethnoracial groups supported differences in tau pathology distribution and coexisting hippocampal sclerosis, which may impact biomarker studies.
KW - African American
KW - Alzheimer disease
KW - Autopsy
KW - Brain
KW - Ethnoracial
KW - Hispanic
KW - Survival
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U2 - 10.1016/j.jalz.2018.12.013
DO - 10.1016/j.jalz.2018.12.013
M3 - Article
C2 - 30792090
AN - SCOPUS:85065137413
SN - 1552-5260
VL - 15
SP - 635
EP - 643
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 5
ER -