Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME)cohort

Octavio A. Santos, Otto D Pedraza, John A Lucas, Ranjan Duara, Maria T. Greig-Custo, Fadi S. Hanna Al-Shaikh, Amanda M. Liesinger, Kevin F. Bieniek, Kelly M. Hinkle, Elizabeth R. Lesser, Juliana Crook, Minerva M Carrasquillo, Owen A Ross, Nilufer Taner, Neill R Graff Radford, Dennis W Dickson, Melissa E Murray

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Our primary goal was to examine demographic and clinicopathologic differences across an ethnoracially diverse autopsy-confirmed cohort of Alzheimer's disease cases. Methods: A retrospective study was conducted in the Florida Autopsied Multi-Ethnic cohort on 1625 Alzheimer's disease cases, including decedents who self-reported as Hispanic/Latino (n = 67), black/African American (n = 19), and white/European American (n = 1539). Results: Hispanic decedents had a higher frequency of family history of cognitive impairment (58%), an earlier age at onset (median age of 70 years), longer disease duration (median of 12 years), and lower MMSE proximal to death (median of 4 points)compared with the other ethnoracial groups. Black decedents had a lower Braak tangle stage (stage V)and higher frequency of coexisting hippocampal sclerosis (21%); however, only hippocampal sclerosis differences survived adjustment for sex, age at onset, and disease duration. Neither Thal amyloid phase nor coexisting Lewy body disease differed across ethnoracial groups. Discussion: Despite a smaller sample size, Hispanics demonstrated longer disease duration with Alzheimer's disease, but not greater lifespan. Neuropathologic differences across ethnoracial groups supported differences in tau pathology distribution and coexisting hippocampal sclerosis, which may impact biomarker studies.

Original languageEnglish (US)
Pages (from-to)635-643
Number of pages9
JournalAlzheimer's and Dementia
Volume15
Issue number5
DOIs
StatePublished - May 1 2019

Fingerprint

Hispanic Americans
Alzheimer Disease
Sclerosis
Age of Onset
Lewy Body Disease
Amyloid
African Americans
Sample Size
Autopsy
Retrospective Studies
Biomarkers
Demography
Pathology

Keywords

  • African American
  • Alzheimer disease
  • Autopsy
  • Brain
  • Ethnoracial
  • Hispanic
  • Survival

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME)cohort. / Santos, Octavio A.; Pedraza, Otto D; Lucas, John A; Duara, Ranjan; Greig-Custo, Maria T.; Hanna Al-Shaikh, Fadi S.; Liesinger, Amanda M.; Bieniek, Kevin F.; Hinkle, Kelly M.; Lesser, Elizabeth R.; Crook, Juliana; Carrasquillo, Minerva M; Ross, Owen A; Taner, Nilufer; Graff Radford, Neill R; Dickson, Dennis W; Murray, Melissa E.

In: Alzheimer's and Dementia, Vol. 15, No. 5, 01.05.2019, p. 635-643.

Research output: Contribution to journalArticle

Santos, Octavio A. ; Pedraza, Otto D ; Lucas, John A ; Duara, Ranjan ; Greig-Custo, Maria T. ; Hanna Al-Shaikh, Fadi S. ; Liesinger, Amanda M. ; Bieniek, Kevin F. ; Hinkle, Kelly M. ; Lesser, Elizabeth R. ; Crook, Juliana ; Carrasquillo, Minerva M ; Ross, Owen A ; Taner, Nilufer ; Graff Radford, Neill R ; Dickson, Dennis W ; Murray, Melissa E. / Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME)cohort. In: Alzheimer's and Dementia. 2019 ; Vol. 15, No. 5. pp. 635-643.
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AU - Santos, Octavio A.

AU - Pedraza, Otto D

AU - Lucas, John A

AU - Duara, Ranjan

AU - Greig-Custo, Maria T.

AU - Hanna Al-Shaikh, Fadi S.

AU - Liesinger, Amanda M.

AU - Bieniek, Kevin F.

AU - Hinkle, Kelly M.

AU - Lesser, Elizabeth R.

AU - Crook, Juliana

AU - Carrasquillo, Minerva M

AU - Ross, Owen A

AU - Taner, Nilufer

AU - Graff Radford, Neill R

AU - Dickson, Dennis W

AU - Murray, Melissa E

PY - 2019/5/1

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N2 - Introduction: Our primary goal was to examine demographic and clinicopathologic differences across an ethnoracially diverse autopsy-confirmed cohort of Alzheimer's disease cases. Methods: A retrospective study was conducted in the Florida Autopsied Multi-Ethnic cohort on 1625 Alzheimer's disease cases, including decedents who self-reported as Hispanic/Latino (n = 67), black/African American (n = 19), and white/European American (n = 1539). Results: Hispanic decedents had a higher frequency of family history of cognitive impairment (58%), an earlier age at onset (median age of 70 years), longer disease duration (median of 12 years), and lower MMSE proximal to death (median of 4 points)compared with the other ethnoracial groups. Black decedents had a lower Braak tangle stage (stage V)and higher frequency of coexisting hippocampal sclerosis (21%); however, only hippocampal sclerosis differences survived adjustment for sex, age at onset, and disease duration. Neither Thal amyloid phase nor coexisting Lewy body disease differed across ethnoracial groups. Discussion: Despite a smaller sample size, Hispanics demonstrated longer disease duration with Alzheimer's disease, but not greater lifespan. Neuropathologic differences across ethnoracial groups supported differences in tau pathology distribution and coexisting hippocampal sclerosis, which may impact biomarker studies.

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KW - Survival

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