Ethnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study

John G. O'Meara, Sharon L R Kardia, Jeffrey J. Armon, C. Andrew Brown, Eric Boerwinkle, Stephen T Turner

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Background: Two ethnically different, community-based samples of hypertensive adults were evaluated to determine the prevalence of dyslipidemia and how often dyslipidemia is drug-treated and controlled by such treatment. Methods: We studied 1286 non-Hispanic black hypertensive subjects from Jackson and 1070 non-Hispanic white hypertensive subjects from Rochester who participated in the Genetic Epidemiology Network of Arteriopathy study. Subjects were categorized according to presence of coronary heart disease and risk factors for coronary heart disease. Results: Prevalence of dyslipidemia was significantly greater among whites than blacks (women, 64.7% vs 49.5%; and men, 78.4% vs 56.7%; P<.001 for both) and among men than women (P≤.02 in each ethnic group). Among dyslipidemic subjects, treatment with lipid-regulating drugs was significantly more common among whites than blacks (women, 25.4% vs 16.4%, P=.001; and men, 32.6% vs 12.8%; P<.001), and among whites, treatment was significantly more common among men than women (P=.03). With drug treatment, control of dyslipidemia varied from 33.9% (white men) to 51.9% (black men), but the differences among ethnic-sex groups were not statistically significant. Conclusions: Dyslipidemia is highly prevalent in hypertensive adults. Fewer than one third of these adults are drug-treated, and fewer than half of those treated achieve recommended goals. Our findings suggest that an alarming 9 of 10 dyslipidemic hypertensive adults have untreated or undertreated dyslipidemia.

Original languageEnglish (US)
Pages (from-to)1313-1318
Number of pages6
JournalArchives of Internal Medicine
Volume164
Issue number12
DOIs
StatePublished - Jun 28 2004

Fingerprint

Dyslipidemias
Sex Characteristics
Ethnic Groups
Lipid Regulating Agents
Coronary Disease
Therapeutics
Pharmaceutical Preparations
Molecular Epidemiology

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Ethnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study. / O'Meara, John G.; Kardia, Sharon L R; Armon, Jeffrey J.; Brown, C. Andrew; Boerwinkle, Eric; Turner, Stephen T.

In: Archives of Internal Medicine, Vol. 164, No. 12, 28.06.2004, p. 1313-1318.

Research output: Contribution to journalArticle

O'Meara, John G. ; Kardia, Sharon L R ; Armon, Jeffrey J. ; Brown, C. Andrew ; Boerwinkle, Eric ; Turner, Stephen T. / Ethnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study. In: Archives of Internal Medicine. 2004 ; Vol. 164, No. 12. pp. 1313-1318.
@article{f2941286d0fe4901b278a6739cb94ed8,
title = "Ethnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study",
abstract = "Background: Two ethnically different, community-based samples of hypertensive adults were evaluated to determine the prevalence of dyslipidemia and how often dyslipidemia is drug-treated and controlled by such treatment. Methods: We studied 1286 non-Hispanic black hypertensive subjects from Jackson and 1070 non-Hispanic white hypertensive subjects from Rochester who participated in the Genetic Epidemiology Network of Arteriopathy study. Subjects were categorized according to presence of coronary heart disease and risk factors for coronary heart disease. Results: Prevalence of dyslipidemia was significantly greater among whites than blacks (women, 64.7{\%} vs 49.5{\%}; and men, 78.4{\%} vs 56.7{\%}; P<.001 for both) and among men than women (P≤.02 in each ethnic group). Among dyslipidemic subjects, treatment with lipid-regulating drugs was significantly more common among whites than blacks (women, 25.4{\%} vs 16.4{\%}, P=.001; and men, 32.6{\%} vs 12.8{\%}; P<.001), and among whites, treatment was significantly more common among men than women (P=.03). With drug treatment, control of dyslipidemia varied from 33.9{\%} (white men) to 51.9{\%} (black men), but the differences among ethnic-sex groups were not statistically significant. Conclusions: Dyslipidemia is highly prevalent in hypertensive adults. Fewer than one third of these adults are drug-treated, and fewer than half of those treated achieve recommended goals. Our findings suggest that an alarming 9 of 10 dyslipidemic hypertensive adults have untreated or undertreated dyslipidemia.",
author = "O'Meara, {John G.} and Kardia, {Sharon L R} and Armon, {Jeffrey J.} and Brown, {C. Andrew} and Eric Boerwinkle and Turner, {Stephen T}",
year = "2004",
month = "6",
day = "28",
doi = "10.1001/archinte.164.12.1313",
language = "English (US)",
volume = "164",
pages = "1313--1318",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "12",

}

TY - JOUR

T1 - Ethnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study

AU - O'Meara, John G.

AU - Kardia, Sharon L R

AU - Armon, Jeffrey J.

AU - Brown, C. Andrew

AU - Boerwinkle, Eric

AU - Turner, Stephen T

PY - 2004/6/28

Y1 - 2004/6/28

N2 - Background: Two ethnically different, community-based samples of hypertensive adults were evaluated to determine the prevalence of dyslipidemia and how often dyslipidemia is drug-treated and controlled by such treatment. Methods: We studied 1286 non-Hispanic black hypertensive subjects from Jackson and 1070 non-Hispanic white hypertensive subjects from Rochester who participated in the Genetic Epidemiology Network of Arteriopathy study. Subjects were categorized according to presence of coronary heart disease and risk factors for coronary heart disease. Results: Prevalence of dyslipidemia was significantly greater among whites than blacks (women, 64.7% vs 49.5%; and men, 78.4% vs 56.7%; P<.001 for both) and among men than women (P≤.02 in each ethnic group). Among dyslipidemic subjects, treatment with lipid-regulating drugs was significantly more common among whites than blacks (women, 25.4% vs 16.4%, P=.001; and men, 32.6% vs 12.8%; P<.001), and among whites, treatment was significantly more common among men than women (P=.03). With drug treatment, control of dyslipidemia varied from 33.9% (white men) to 51.9% (black men), but the differences among ethnic-sex groups were not statistically significant. Conclusions: Dyslipidemia is highly prevalent in hypertensive adults. Fewer than one third of these adults are drug-treated, and fewer than half of those treated achieve recommended goals. Our findings suggest that an alarming 9 of 10 dyslipidemic hypertensive adults have untreated or undertreated dyslipidemia.

AB - Background: Two ethnically different, community-based samples of hypertensive adults were evaluated to determine the prevalence of dyslipidemia and how often dyslipidemia is drug-treated and controlled by such treatment. Methods: We studied 1286 non-Hispanic black hypertensive subjects from Jackson and 1070 non-Hispanic white hypertensive subjects from Rochester who participated in the Genetic Epidemiology Network of Arteriopathy study. Subjects were categorized according to presence of coronary heart disease and risk factors for coronary heart disease. Results: Prevalence of dyslipidemia was significantly greater among whites than blacks (women, 64.7% vs 49.5%; and men, 78.4% vs 56.7%; P<.001 for both) and among men than women (P≤.02 in each ethnic group). Among dyslipidemic subjects, treatment with lipid-regulating drugs was significantly more common among whites than blacks (women, 25.4% vs 16.4%, P=.001; and men, 32.6% vs 12.8%; P<.001), and among whites, treatment was significantly more common among men than women (P=.03). With drug treatment, control of dyslipidemia varied from 33.9% (white men) to 51.9% (black men), but the differences among ethnic-sex groups were not statistically significant. Conclusions: Dyslipidemia is highly prevalent in hypertensive adults. Fewer than one third of these adults are drug-treated, and fewer than half of those treated achieve recommended goals. Our findings suggest that an alarming 9 of 10 dyslipidemic hypertensive adults have untreated or undertreated dyslipidemia.

UR - http://www.scopus.com/inward/record.url?scp=3042551237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042551237&partnerID=8YFLogxK

U2 - 10.1001/archinte.164.12.1313

DO - 10.1001/archinte.164.12.1313

M3 - Article

C2 - 15226165

AN - SCOPUS:3042551237

VL - 164

SP - 1313

EP - 1318

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 12

ER -