Estrogen-TGFβ cross-talk in bone and other cell types: Role of TIEG, Runx2, and other transcription factors

J. R. Hawse, M. Subramaniam, J. N. Ingle, M. J. Oursler, N. M. Rajamannan, T. C. Spelsberg

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

It is well established that E2 and TGFβ have major biological effects in multiple tissues, including bone. The signaling pathways through which these two factors elicit their effects are well documented. However, the interaction between these two pathways and the potential consequences of cross-talk between E2 and TGFβ continue to be elucidated. In this prospectus, we present known and potential roles of TIEC, Runx2, and other transcription factors as important mediators of signaling between these two pathways.

Original languageEnglish (US)
Pages (from-to)383-392
Number of pages10
JournalJournal of cellular biochemistry
Volume103
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Bone
  • Estrogen
  • Osteoblast
  • Osteoclast
  • Runx2
  • TGFβ
  • TIEG

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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