Estrogen-TGFβ cross-talk in bone and other cell types: Role of TIEG, Runx2, and other transcription factors

J. R. Hawse; M. Subramaniam; J. N. Ingle; M. J. Oursler; N. M. Rajamannan; T. C. Spelsberg

doi:10.1002/jcb.21425

Estrogen-TGFβ cross-talk in bone and other cell types: Role of TIEG, Runx2, and other transcription factors

J. R. Hawse, M. Subramaniam, J. N. Ingle, M. J. Oursler, N. M. Rajamannan, T. C. Spelsberg

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

It is well established that E₂ and TGFβ have major biological effects in multiple tissues, including bone. The signaling pathways through which these two factors elicit their effects are well documented. However, the interaction between these two pathways and the potential consequences of cross-talk between E₂ and TGFβ continue to be elucidated. In this prospectus, we present known and potential roles of TIEC, Runx2, and other transcription factors as important mediators of signaling between these two pathways.

Original language	English (US)
Pages (from-to)	383-392
Number of pages	10
Journal	Journal of cellular biochemistry
Volume	103
Issue number	2
DOIs	https://doi.org/10.1002/jcb.21425
State	Published - Feb 1 2008

Keywords

Bone
Estrogen
Osteoblast
Osteoclast
Runx2
TGFβ
TIEG

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1002/jcb.21425

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AU - Ingle, J. N.

AU - Oursler, M. J.

AU - Rajamannan, N. M.

AU - Spelsberg, T. C.

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AB - It is well established that E2 and TGFβ have major biological effects in multiple tissues, including bone. The signaling pathways through which these two factors elicit their effects are well documented. However, the interaction between these two pathways and the potential consequences of cross-talk between E2 and TGFβ continue to be elucidated. In this prospectus, we present known and potential roles of TIEC, Runx2, and other transcription factors as important mediators of signaling between these two pathways.

KW - Bone

KW - Estrogen

KW - Osteoblast

KW - Osteoclast

KW - Runx2

KW - TGFβ

KW - TIEG

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Estrogen-TGFβ cross-talk in bone and other cell types: Role of TIEG, Runx2, and other transcription factors

Abstract

Keywords

ASJC Scopus subject areas

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