Estrogen, selective estrogen receptor modulators and now mechanism-specific ligands of the estrogen or androgen receptor?

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Estrogen, the traditional treatment of both short- and long-term consequences of the menopause, has fallen into disfavor. Thus, selective estrogen receptor modulators (SERMs) have been used as an alternative approach to activate estrogen signaling pathways in a tissue-specific manner. In addition, recent findings indicate that some compounds might activate specific estrogen signaling pathways that are beneficial without affecting other pathways that might lead to the harmful side-effects associated with estrogen. These so-called mechanism-specific ligands of estrogen or androgen receptors hold considerable promise as novel approaches to treat (or at least ameliorate) the consequences of estrogen deficiency.

Original languageEnglish (US)
Pages (from-to)261-263
Number of pages3
JournalTrends in Pharmacological Sciences
Volume24
Issue number6
DOIs
StatePublished - Jun 1 2003

Fingerprint

Selective Estrogen Receptor Modulators
Androgen Receptors
Estrogen Receptors
Estrogens
Ligands
Menopause
Tissue

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

@article{ca5d239153a14e778c09a835881d6639,
title = "Estrogen, selective estrogen receptor modulators and now mechanism-specific ligands of the estrogen or androgen receptor?",
abstract = "Estrogen, the traditional treatment of both short- and long-term consequences of the menopause, has fallen into disfavor. Thus, selective estrogen receptor modulators (SERMs) have been used as an alternative approach to activate estrogen signaling pathways in a tissue-specific manner. In addition, recent findings indicate that some compounds might activate specific estrogen signaling pathways that are beneficial without affecting other pathways that might lead to the harmful side-effects associated with estrogen. These so-called mechanism-specific ligands of estrogen or androgen receptors hold considerable promise as novel approaches to treat (or at least ameliorate) the consequences of estrogen deficiency.",
author = "Sundeep Khosla",
year = "2003",
month = "6",
day = "1",
doi = "10.1016/S0165-6147(03)00124-X",
language = "English (US)",
volume = "24",
pages = "261--263",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Estrogen, selective estrogen receptor modulators and now mechanism-specific ligands of the estrogen or androgen receptor?

AU - Khosla, Sundeep

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Estrogen, the traditional treatment of both short- and long-term consequences of the menopause, has fallen into disfavor. Thus, selective estrogen receptor modulators (SERMs) have been used as an alternative approach to activate estrogen signaling pathways in a tissue-specific manner. In addition, recent findings indicate that some compounds might activate specific estrogen signaling pathways that are beneficial without affecting other pathways that might lead to the harmful side-effects associated with estrogen. These so-called mechanism-specific ligands of estrogen or androgen receptors hold considerable promise as novel approaches to treat (or at least ameliorate) the consequences of estrogen deficiency.

AB - Estrogen, the traditional treatment of both short- and long-term consequences of the menopause, has fallen into disfavor. Thus, selective estrogen receptor modulators (SERMs) have been used as an alternative approach to activate estrogen signaling pathways in a tissue-specific manner. In addition, recent findings indicate that some compounds might activate specific estrogen signaling pathways that are beneficial without affecting other pathways that might lead to the harmful side-effects associated with estrogen. These so-called mechanism-specific ligands of estrogen or androgen receptors hold considerable promise as novel approaches to treat (or at least ameliorate) the consequences of estrogen deficiency.

UR - http://www.scopus.com/inward/record.url?scp=0038680396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038680396&partnerID=8YFLogxK

U2 - 10.1016/S0165-6147(03)00124-X

DO - 10.1016/S0165-6147(03)00124-X

M3 - Article

C2 - 12823947

AN - SCOPUS:0038680396

VL - 24

SP - 261

EP - 263

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 6

ER -