TY - JOUR
T1 - Estrogen, selective estrogen receptor modulators and now mechanism-specific ligands of the estrogen or androgen receptor?
AU - Khosla, Sundeep
N1 - Funding Information:
Supported by research grant AG04875 and AR27065 from the National Institute on Aging, United States Public Health Service.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Estrogen, the traditional treatment of both short- and long-term consequences of the menopause, has fallen into disfavor. Thus, selective estrogen receptor modulators (SERMs) have been used as an alternative approach to activate estrogen signaling pathways in a tissue-specific manner. In addition, recent findings indicate that some compounds might activate specific estrogen signaling pathways that are beneficial without affecting other pathways that might lead to the harmful side-effects associated with estrogen. These so-called mechanism-specific ligands of estrogen or androgen receptors hold considerable promise as novel approaches to treat (or at least ameliorate) the consequences of estrogen deficiency.
AB - Estrogen, the traditional treatment of both short- and long-term consequences of the menopause, has fallen into disfavor. Thus, selective estrogen receptor modulators (SERMs) have been used as an alternative approach to activate estrogen signaling pathways in a tissue-specific manner. In addition, recent findings indicate that some compounds might activate specific estrogen signaling pathways that are beneficial without affecting other pathways that might lead to the harmful side-effects associated with estrogen. These so-called mechanism-specific ligands of estrogen or androgen receptors hold considerable promise as novel approaches to treat (or at least ameliorate) the consequences of estrogen deficiency.
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U2 - 10.1016/S0165-6147(03)00124-X
DO - 10.1016/S0165-6147(03)00124-X
M3 - Short survey
C2 - 12823947
AN - SCOPUS:0038680396
SN - 0165-6147
VL - 24
SP - 261
EP - 263
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 6
ER -