Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover

Basem M. Abdallah, Anne Christine Bay-Jensen, Bhuma Srinivasan, Nadine C. Tabassi, Patrick Garnero, Jean Marie Delaissé, Sundeep Khosla, Moustapha Kassem

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n=100) and a group of postmenopausal women, where half had received estrogen-replacement therapy (ERT, n=166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p<0.001). s-Dlk1/FA1 was correlated with s-CTX (r=0.30, p<0.01). ERT in postmenopausal women decreased s-Dlk1/FA1, as well as s-CTX and s-osteoclacin (all p<.0001). Changes in s-Dlk1 were significantly correlated with those observed in s-CTX (r=0.18, p<0.05) and s-osteocalcin (r=0.28, p<0.001). In conclusion, s-Dlk1/FA1 is influenced by E-deficiency and is correlated with bone turnover. Increased levels of s-Dlk1/FA1 in postmenopausal women may be a mechanism mediating the effects of estrogen deficiency on bone turnover.

Original languageEnglish (US)
Pages (from-to)2548-2551
Number of pages4
JournalJournal of Bone and Mineral Research
Volume26
Issue number10
DOIs
StatePublished - Oct 2011

Fingerprint

Bone Remodeling
Estrogens
Antigens
Osteocalcin
Bone and Bones
Estrogen Replacement Therapy
Serum
Biomarkers

Keywords

  • bone turnover
  • Dlk1
  • estrogen
  • FA1
  • PREF -1

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Abdallah, B. M., Bay-Jensen, A. C., Srinivasan, B., Tabassi, N. C., Garnero, P., Delaissé, J. M., ... Kassem, M. (2011). Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover. Journal of Bone and Mineral Research, 26(10), 2548-2551. https://doi.org/10.1002/jbmr.444

Estrogen inhibits Dlk1/FA1 production : A potential mechanism for estrogen effects on bone turnover. / Abdallah, Basem M.; Bay-Jensen, Anne Christine; Srinivasan, Bhuma; Tabassi, Nadine C.; Garnero, Patrick; Delaissé, Jean Marie; Khosla, Sundeep; Kassem, Moustapha.

In: Journal of Bone and Mineral Research, Vol. 26, No. 10, 10.2011, p. 2548-2551.

Research output: Contribution to journalArticle

Abdallah, BM, Bay-Jensen, AC, Srinivasan, B, Tabassi, NC, Garnero, P, Delaissé, JM, Khosla, S & Kassem, M 2011, 'Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover', Journal of Bone and Mineral Research, vol. 26, no. 10, pp. 2548-2551. https://doi.org/10.1002/jbmr.444
Abdallah BM, Bay-Jensen AC, Srinivasan B, Tabassi NC, Garnero P, Delaissé JM et al. Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover. Journal of Bone and Mineral Research. 2011 Oct;26(10):2548-2551. https://doi.org/10.1002/jbmr.444
Abdallah, Basem M. ; Bay-Jensen, Anne Christine ; Srinivasan, Bhuma ; Tabassi, Nadine C. ; Garnero, Patrick ; Delaissé, Jean Marie ; Khosla, Sundeep ; Kassem, Moustapha. / Estrogen inhibits Dlk1/FA1 production : A potential mechanism for estrogen effects on bone turnover. In: Journal of Bone and Mineral Research. 2011 ; Vol. 26, No. 10. pp. 2548-2551.
@article{b59e522e3ed64835a751690fc5329303,
title = "Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover",
abstract = "We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n=100) and a group of postmenopausal women, where half had received estrogen-replacement therapy (ERT, n=166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p<0.001). s-Dlk1/FA1 was correlated with s-CTX (r=0.30, p<0.01). ERT in postmenopausal women decreased s-Dlk1/FA1, as well as s-CTX and s-osteoclacin (all p<.0001). Changes in s-Dlk1 were significantly correlated with those observed in s-CTX (r=0.18, p<0.05) and s-osteocalcin (r=0.28, p<0.001). In conclusion, s-Dlk1/FA1 is influenced by E-deficiency and is correlated with bone turnover. Increased levels of s-Dlk1/FA1 in postmenopausal women may be a mechanism mediating the effects of estrogen deficiency on bone turnover.",
keywords = "bone turnover, Dlk1, estrogen, FA1, PREF -1",
author = "Abdallah, {Basem M.} and Bay-Jensen, {Anne Christine} and Bhuma Srinivasan and Tabassi, {Nadine C.} and Patrick Garnero and Delaiss{\'e}, {Jean Marie} and Sundeep Khosla and Moustapha Kassem",
year = "2011",
month = "10",
doi = "10.1002/jbmr.444",
language = "English (US)",
volume = "26",
pages = "2548--2551",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Estrogen inhibits Dlk1/FA1 production

T2 - A potential mechanism for estrogen effects on bone turnover

AU - Abdallah, Basem M.

AU - Bay-Jensen, Anne Christine

AU - Srinivasan, Bhuma

AU - Tabassi, Nadine C.

AU - Garnero, Patrick

AU - Delaissé, Jean Marie

AU - Khosla, Sundeep

AU - Kassem, Moustapha

PY - 2011/10

Y1 - 2011/10

N2 - We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n=100) and a group of postmenopausal women, where half had received estrogen-replacement therapy (ERT, n=166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p<0.001). s-Dlk1/FA1 was correlated with s-CTX (r=0.30, p<0.01). ERT in postmenopausal women decreased s-Dlk1/FA1, as well as s-CTX and s-osteoclacin (all p<.0001). Changes in s-Dlk1 were significantly correlated with those observed in s-CTX (r=0.18, p<0.05) and s-osteocalcin (r=0.28, p<0.001). In conclusion, s-Dlk1/FA1 is influenced by E-deficiency and is correlated with bone turnover. Increased levels of s-Dlk1/FA1 in postmenopausal women may be a mechanism mediating the effects of estrogen deficiency on bone turnover.

AB - We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n=100) and a group of postmenopausal women, where half had received estrogen-replacement therapy (ERT, n=166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p<0.001). s-Dlk1/FA1 was correlated with s-CTX (r=0.30, p<0.01). ERT in postmenopausal women decreased s-Dlk1/FA1, as well as s-CTX and s-osteoclacin (all p<.0001). Changes in s-Dlk1 were significantly correlated with those observed in s-CTX (r=0.18, p<0.05) and s-osteocalcin (r=0.28, p<0.001). In conclusion, s-Dlk1/FA1 is influenced by E-deficiency and is correlated with bone turnover. Increased levels of s-Dlk1/FA1 in postmenopausal women may be a mechanism mediating the effects of estrogen deficiency on bone turnover.

KW - bone turnover

KW - Dlk1

KW - estrogen

KW - FA1

KW - PREF -1

UR - http://www.scopus.com/inward/record.url?scp=80053194786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053194786&partnerID=8YFLogxK

U2 - 10.1002/jbmr.444

DO - 10.1002/jbmr.444

M3 - Article

C2 - 21681814

AN - SCOPUS:80053194786

VL - 26

SP - 2548

EP - 2551

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 10

ER -