Estrogen and progesterone receptors in lymphangioleiomyomatosis, epithelioid hemangioendothelioma, and sclerosing hemangioma of the lung

N. P. Ohori, S. A. Yousem, E. Sonmez-Alpan, T. V. Colby

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

The therapeutic options in the treatment of lung neoplasia usually have not included hormonal therapy, unlike those for primary tumors of other sites (e.g., breast). However, two mesenchymal proliferations of lung, lymphangioleiomyomatosis and epithelioid hemangioendothelioma (EHE), and one epithelial tumor, sclerosing hemangioma (SH), have a significant female predilection and may benefit from such hormonal therapy. The authors investigated five cases each of EHE and lymphangioleiomyomatosis and four cases of SH for expression of estrogen and progesterone receptors and 17-beta estradiol in paraffin-embedded tissue. Only one case each of lymphangioleiomyomatosis and EHE expressed 17-beta estradiol. All of the other cases were negative. These findings are contrary to the viewpoint held in published literature, especially in case reports of lymphangioleiomyomatosis, describing patients with positive estrogen and progesterone receptor results. Consequently, a number of issues must be considered in the clinical and immunohistochemical evaluation of the estrogen and progesterone receptor status of these rare pulmonary neoplasms.

Original languageEnglish (US)
Pages (from-to)529-535
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume96
Issue number4
StatePublished - 1991
Externally publishedYes

Fingerprint

Pulmonary Sclerosing Hemangioma
Epithelioid Hemangioendothelioma
Lymphangioleiomyomatosis
Progesterone Receptors
Estrogen Receptors
Benign Fibrous Histiocytoma
Estradiol
Neoplasms
Lung
Therapeutics
Paraffin
Lung Neoplasms
Breast

Keywords

  • Epithelioid hemangioendothelioma
  • Estrogen receptor
  • Lung neoplasia
  • Lymphangioleiomyomatosis
  • Progesterone receptor
  • Sclerosing hemangioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Estrogen and progesterone receptors in lymphangioleiomyomatosis, epithelioid hemangioendothelioma, and sclerosing hemangioma of the lung. / Ohori, N. P.; Yousem, S. A.; Sonmez-Alpan, E.; Colby, T. V.

In: American Journal of Clinical Pathology, Vol. 96, No. 4, 1991, p. 529-535.

Research output: Contribution to journalArticle

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