Estimation of the absolute shear stiffness of human lung parenchyma using 1h spin echo, echo planar MR elastography

Yogesh K. Mariappan, Kevin J. Glaser, David L. Levin, Robert Vassallo, Rolf D. Hubmayr, Carl Mottram, Richard Lorne Ehman, Kiaran Patrick McGee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To develop a rapid proton MR elastography (MRE) technique that can quantify the absolute shear stiffness of lung parenchyma, to investigate the ability to differentiate respiration-dependent stiffness variations of the lung, and to demonstrate clinical feasibility.

Materials and Methods: A spin-echo echo planar imaging MRE sequence (SE-EPI MRE) with a very short echo time was developed and tested in a series of five healthy volunteers at three different lung volumes: (i) residual volume (RV), (ii) total lung capacity (TLC), (iii) and midway between RV and TLC (MID). At each volume, lung density was quantified using a MR-based density mapping sequence. For reference, data were acquired using the previously described spin-echo lung MRE sequence (SEMRE). MRE data were also acquired in a patient with proven Idiopathic Pulmonary Fibrosis (IPF) to test clinical feasibility.

Results: The SE-EPIMRE sequence reduced total acquisition time by a factor of 2 compared with the SE-MRE sequence. Lung parenchyma median shear stiffness for the 5 volunteers quantified with the SE-EPI MRE sequence was 0.9 kPa, 1.1 kPa, and 1.6 kPa at RV, MID, and TLC, respectively. The corresponding values obtained with the SE-MRE sequence were 0.9 kPa, 1.1 kPa, and 1.5 kPa. Absolute shear stiffness was also successfully measured in the IPF patient.

Conclusion: The results indicate that stiffness variations due to respiration could be measured with the SE-EPIMRE technique and were equivalent to values generated by the previously described SE-MRE approach. Preliminary data obtained from the patient demonstrate clinical feasibility.

Original languageEnglish (US)
Pages (from-to)1230-1237
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume40
Issue number5
DOIs
StatePublished - Nov 1 2014

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Elasticity Imaging Techniques
Lung
Total Lung Capacity
Residual Volume
Echo-Planar Imaging
Idiopathic Pulmonary Fibrosis
Respiration
Protons
Volunteers
Healthy Volunteers

Keywords

  • Interstitial lung disease
  • Lung fibrosis
  • Lung MR elastography
  • Magnetic resonance elastography
  • Shear stiffness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Estimation of the absolute shear stiffness of human lung parenchyma using 1h spin echo, echo planar MR elastography. / Mariappan, Yogesh K.; Glaser, Kevin J.; Levin, David L.; Vassallo, Robert; Hubmayr, Rolf D.; Mottram, Carl; Ehman, Richard Lorne; McGee, Kiaran Patrick.

In: Journal of Magnetic Resonance Imaging, Vol. 40, No. 5, 01.11.2014, p. 1230-1237.

Research output: Contribution to journalArticle

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AU - Mariappan, Yogesh K.

AU - Glaser, Kevin J.

AU - Levin, David L.

AU - Vassallo, Robert

AU - Hubmayr, Rolf D.

AU - Mottram, Carl

AU - Ehman, Richard Lorne

AU - McGee, Kiaran Patrick

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N2 - Purpose: To develop a rapid proton MR elastography (MRE) technique that can quantify the absolute shear stiffness of lung parenchyma, to investigate the ability to differentiate respiration-dependent stiffness variations of the lung, and to demonstrate clinical feasibility.Materials and Methods: A spin-echo echo planar imaging MRE sequence (SE-EPI MRE) with a very short echo time was developed and tested in a series of five healthy volunteers at three different lung volumes: (i) residual volume (RV), (ii) total lung capacity (TLC), (iii) and midway between RV and TLC (MID). At each volume, lung density was quantified using a MR-based density mapping sequence. For reference, data were acquired using the previously described spin-echo lung MRE sequence (SEMRE). MRE data were also acquired in a patient with proven Idiopathic Pulmonary Fibrosis (IPF) to test clinical feasibility.Results: The SE-EPIMRE sequence reduced total acquisition time by a factor of 2 compared with the SE-MRE sequence. Lung parenchyma median shear stiffness for the 5 volunteers quantified with the SE-EPI MRE sequence was 0.9 kPa, 1.1 kPa, and 1.6 kPa at RV, MID, and TLC, respectively. The corresponding values obtained with the SE-MRE sequence were 0.9 kPa, 1.1 kPa, and 1.5 kPa. Absolute shear stiffness was also successfully measured in the IPF patient.Conclusion: The results indicate that stiffness variations due to respiration could be measured with the SE-EPIMRE technique and were equivalent to values generated by the previously described SE-MRE approach. Preliminary data obtained from the patient demonstrate clinical feasibility.

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KW - Lung fibrosis

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KW - Magnetic resonance elastography

KW - Shear stiffness

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