Abstract
Arterial elasticity has gained importance in the past few decades as a predictor of cardiovascular diseases and mortality [1]. We propose a noninvasive technique using ultrasound radiation force and measurement of shear wave speed to calculate the mechanical properties of soft tubes and arteries noninvasively. To validate the technique we made three urethane tubes with different Young's moduli, tested the tubes and used the measured tube wall's shear wave speed and the modified Moens-Korteweg equation to estimate the Young's moduli. Samples of the same material were mechanically tested to compare the results from our technique. Excised carotid arteries from a pig were used to study the applicability of our method in soft tissues. Both the tubes and the arteries were embedded in gelatin to simulate the soft tissue surrounding the arteries, and pressurized using a column of water. The results from the tubes were in very good agreement with the mechanical testing, and the shear wave speed did not seem to change very much with change in transmural pressure. On the other hand, the excised arteries showed an increase in shear wave velocity with pressure and an increase in the Young's modulus. The technique we present here showed to be in good agreement with mechanical testing which gives us confidence to think that it can be applied in the study of arteries in vivo. Efforts towards implementing this technique in a clinical scanner are underway.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings - IEEE Ultrasonics Symposium |
| DOIs | |
| State | Published - 2009 |
| Event | 2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy Duration: Sep 20 2009 → Sep 23 2009 |
Other
| Other | 2009 IEEE International Ultrasonics Symposium, IUS 2009 |
|---|---|
| Country | Italy |
| City | Rome |
| Period | 9/20/09 → 9/23/09 |
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Keywords
- Arterial elasticity
- Mechanical testing
- Shear wave
- Young's modulus
ASJC Scopus subject areas
- Acoustics and Ultrasonics
Cite this
Estimation of mechanical properties of arteries and soft tubes using shear wave speeds. / Bernal, Miguel; Urban, Matthew W; Greenleaf, James F.
Proceedings - IEEE Ultrasonics Symposium. 2009. 5441409.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Estimation of mechanical properties of arteries and soft tubes using shear wave speeds
AU - Bernal, Miguel
AU - Urban, Matthew W
AU - Greenleaf, James F
PY - 2009
Y1 - 2009
N2 - Arterial elasticity has gained importance in the past few decades as a predictor of cardiovascular diseases and mortality [1]. We propose a noninvasive technique using ultrasound radiation force and measurement of shear wave speed to calculate the mechanical properties of soft tubes and arteries noninvasively. To validate the technique we made three urethane tubes with different Young's moduli, tested the tubes and used the measured tube wall's shear wave speed and the modified Moens-Korteweg equation to estimate the Young's moduli. Samples of the same material were mechanically tested to compare the results from our technique. Excised carotid arteries from a pig were used to study the applicability of our method in soft tissues. Both the tubes and the arteries were embedded in gelatin to simulate the soft tissue surrounding the arteries, and pressurized using a column of water. The results from the tubes were in very good agreement with the mechanical testing, and the shear wave speed did not seem to change very much with change in transmural pressure. On the other hand, the excised arteries showed an increase in shear wave velocity with pressure and an increase in the Young's modulus. The technique we present here showed to be in good agreement with mechanical testing which gives us confidence to think that it can be applied in the study of arteries in vivo. Efforts towards implementing this technique in a clinical scanner are underway.
AB - Arterial elasticity has gained importance in the past few decades as a predictor of cardiovascular diseases and mortality [1]. We propose a noninvasive technique using ultrasound radiation force and measurement of shear wave speed to calculate the mechanical properties of soft tubes and arteries noninvasively. To validate the technique we made three urethane tubes with different Young's moduli, tested the tubes and used the measured tube wall's shear wave speed and the modified Moens-Korteweg equation to estimate the Young's moduli. Samples of the same material were mechanically tested to compare the results from our technique. Excised carotid arteries from a pig were used to study the applicability of our method in soft tissues. Both the tubes and the arteries were embedded in gelatin to simulate the soft tissue surrounding the arteries, and pressurized using a column of water. The results from the tubes were in very good agreement with the mechanical testing, and the shear wave speed did not seem to change very much with change in transmural pressure. On the other hand, the excised arteries showed an increase in shear wave velocity with pressure and an increase in the Young's modulus. The technique we present here showed to be in good agreement with mechanical testing which gives us confidence to think that it can be applied in the study of arteries in vivo. Efforts towards implementing this technique in a clinical scanner are underway.
KW - Arterial elasticity
KW - Mechanical testing
KW - Shear wave
KW - Young's modulus
UR - http://www.scopus.com/inward/record.url?scp=77952823380&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952823380&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2009.5441409
DO - 10.1109/ULTSYM.2009.5441409
M3 - Conference contribution
AN - SCOPUS:77952823380
SN - 9781424443895
BT - Proceedings - IEEE Ultrasonics Symposium
ER -